8-Bromoisoquinoline
- CAS No.
- 63927-22-0
- Chemical Name:
- 8-Bromoisoquinoline
- Synonyms
- 8-BromoisoquinoL;8-BROMOISOQUINOLINE;Isoquinoline, 8-bromo-;8-Bromoisoquinoline 95%;8-Bromoisoquinoline >8-Bromoisoquinoline ,97%;8-Bromo-isoquinoline()/98%/50g;8-Bromoisoquinoline ISO 9001：2015 REACH
- CBNumber:
- CB5217212
- Molecular Formula:
- C9H6BrN
- Molecular Weight:
- 208.05
- MDL Number:
- MFCD04973298
- MOL File:
- 63927-22-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 8-Bromoisoquinoline >97.0%(GC)(T) | B4144 | 1g | $30 |
| 8-Bromoisoquinoline >97.0%(GC)(T) | B4144 | 5g | $117 |
| 8-Bromoisoquinoline ≥95% | 10007082 | 500mg | $37 |
| 8-Bromoisoquinoline ≥95% | 10007082 | 1g | $59 |
| 8-Bromoisoquinoline ≥99% | 10007082 | 500mg | $33 |
| More product size | |||
| Melting point | 80,5 C |
|---|---|
| Boiling point | 312.3±15.0 °C(Predicted) |
| Density | 1.564±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:8): .5 mg/ml |
| form | powder to crystal |
| pka | 4.63±0.23(Predicted) |
| color | Light orange to Yellow to Green |
| InChI | InChI=1S/C9H6BrN/c10-9-3-1-2-7-4-5-11-6-8(7)9/h1-6H |
| InChIKey | DPRIHFQFWWCIGY-UHFFFAOYSA-N |
| SMILES | C1C2=C(C=CC=C2Br)C=CN=1 |
| CAS DataBase Reference | 63927-22-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi,Xn,T | |||||||||
| Risk Statements | 36/37/38-20/21/22-25 | |||||||||
| Safety Statements | 26-36-45 | |||||||||
| RIDADR | 2811 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29334900 | |||||||||
| NFPA 704 |
|
8-Bromoisoquinoline price More Price(109)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4144 | 8-Bromoisoquinoline >97.0%(GC)(T) | 63927-22-0 | 1g | $30 | 2026-04-30 | Buy |
| TCI Chemical | B4144 | 8-Bromoisoquinoline >97.0%(GC)(T) | 63927-22-0 | 5g | $117 | 2026-04-30 | Buy |
| Cayman Chemical | 10007082 | 8-Bromoisoquinoline ≥95% | 63927-22-0 | 500mg | $37 | 2026-04-30 | Buy |
| Cayman Chemical | 10007082 | 8-Bromoisoquinoline ≥95% | 63927-22-0 | 1g | $59 | 2026-04-30 | Buy |
| Cayman Chemical | 10007082 | 8-Bromoisoquinoline ≥99% | 63927-22-0 | 500mg | $33 | 2024-03-01 | Buy |
8-Bromoisoquinoline Chemical Properties,Uses,Production
Chemical Properties
Yellow powder
Uses
8-Bromoisoquinoline is an intermediate used to prepare 4-((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-Lipoxygenase. It is also used in the synthesis of selective excitatory amino acid transporter subtype 1 (EAAT1) Inhibitor UCPH-102.
Synthesis
6630-33-7
22483-09-6
63927-22-0
1. 2-Bromobenzaldehyde (50 g, 270 mmol), aminoglyoxal dimethyl acetal (28.4 g, 270 mmol) and toluene (400 mL) were mixed under argon protection and heated to reflux. The dehydration reaction was carried out for 2.0 hours using a Dean-Stark apparatus. After dehydration was completed, reflux was continued for 1.0 hour. 2. Upon completion of the reaction, toluene was removed by evaporation under reduced pressure, the residue was dissolved in dichloromethane (600 mL), and the solution was cooled to 0°C. The reaction was then purged by evaporation under reduced pressure. 3. Aluminum chloride (118.9 g, 891.7 mmol) was slowly added to the cooled solution under argon protection, and the reaction mixture was then stirred at 45°C for 2.0 hours. 4. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water. 5. The dichloromethane layer was separated by alkalizing the mixture with 10% sodium hydroxide solution. The aqueous layer was re-extracted with dichloromethane (2 x 100mL). 6. The methylene chloride layer was combined, washed with brine and dried over anhydrous sodium sulfate. 7. The dichloromethane was removed by evaporation and the residue was purified by column chromatography on silica gel (100-200 mesh) to afford 8-bromoisoquinoline as an off-white solid (28 g, 49.8% yield) using a 5-8% ethyl acetate solution in hexane as the mobile phase. MS (ESI) m/z: 208 [M(79Br)+1], 210 [M(81Br)+1]; 1H NMR (400 MHz, DMSO-d6): δ 7.17 (t, J=7.8 Hz, 1H); 7.91 (d, J=6.0 Hz, 1H); 8.02 (d, J=8.4 Hz, 1H); 8.05 (d, J= 8.8 Hz, 1H); 8.65 (d, J=5.2 Hz, 1H); 9.48 (s, 1H).
References
[1] Patent: WO2016/21742, 2016, A1. Location in patent: Paragraph 0222; 0223
8-Bromoisoquinoline Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-15225627621 +86-13213167925 | jiuyitime@fdachem.com | China | 16510 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14025 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29793 | 58 |
View Lastest Price from 8-Bromoisoquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-02 | 8-Bromoisoquinoline
63927-22-0
|
$2.20-8.80 | 1kg | 99%min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-03-20 | 8-Bromoisoquinoline
63927-22-0
|
$9.80 | 1KG | 99% | 10 tons | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-11-18 | 8-Bromoisoquinoline
63927-22-0
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited |
-
- 8-Bromoisoquinoline
63927-22-0
- $2.20-8.80
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 8-Bromoisoquinoline
63927-22-0
- $9.80
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 8-Bromoisoquinoline
63927-22-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
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