ChemicalBook >> CAS DataBase List >>2,4,6-Triisopropylbenzenesulfonyl chloride
2,4,6-Triisopropylbenzenesulfonyl chloride
- CAS No.
- 6553-96-4
- Chemical Name:
- 2,4,6-Triisopropylbenzenesulfonyl chloride
- Synonyms
- TPSCL;TPS;2,4,6-Triisopropylphenylsulfonyl chloride;2,4,6-Triisopropylbenzene-1-sulfonyl chloride;Trisyl chloride;2,4,6-tris(propan-2-yl)benzene-1-sulfonyl chloride;2,4,6-Tris(1-methylethyl)benzenesulfonyl chloride;TIMTEC-BB SBB001244;LABOTEST-BB LT00233201;TRI ARYL SULFONIUM CHLORIDE
- CBNumber:
- CB5251818
- Molecular Formula:
- C15H23ClO2S
- Molecular Weight:
- 302.86
- MDL Number:
- MFCD00007433
- MOL File:
- 6553-96-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-06-04 16:00:12
| Product description | Number | Pack Size | Price |
| 2,4,6-Triisopropylbenzenesulfonyl chloride 97% | 119490 | 25g | $87.9 |
| 2,4,6-Triisopropylbenzenesulfonyl chloride 97% | 119490 | 100g | $217 |
| 2,4,6-Triisopropylbenzenesulfonyl Chloride >97.0%(T) | T0459 | 25g | $21 |
| 2,4,6-Triisopropylbenzenesulfonyl Chloride >97.0%(T) | T0459 | 500g | $269 |
| 2,4,6-Triisopropylbenzenesulfonyl chloride 99+% ≥99%(Titration) | 230940 | 5g | $156 |
| More product size | |||
| Melting point | 92-94 °C (lit.) |
|---|---|
| Boiling point | 378C |
| Density | 1.1012 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | ethanol: 50 mg/mL, clear |
| form | Crystalline Solid |
| color | White to slightly beige |
| Water Solubility | decomposes |
| Sensitive | Moisture Sensitive |
| BRN | 1218575 |
| InChI | InChI=1S/C15H23ClO2S/c1-9(2)12-7-13(10(3)4)15(19(16,17)18)14(8-12)11(5)6/h7-11H,1-6H3 |
| InChIKey | JAPYIBBSTJFDAK-UHFFFAOYSA-N |
| SMILES | C1(S(Cl)(=O)=O)=C(C(C)C)C=C(C(C)C)C=C1C(C)C |
| CAS DataBase Reference | 6553-96-4(CAS DataBase Reference) |
| FDA UNII | 4QZ3QZX6G4 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-29 | |||||||||
| Safety Statements | 26-36/37/39-45-27 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 21 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29049020 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
2,4,6-Triisopropylbenzenesulfonyl chloride price More Price(100)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 119490 | 2,4,6-Triisopropylbenzenesulfonyl chloride 97% | 6553-96-4 | 25g | $87.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | 119490 | 2,4,6-Triisopropylbenzenesulfonyl chloride 97% | 6553-96-4 | 100g | $217 | 2026-04-30 | Buy |
| TCI Chemical | T0459 | 2,4,6-Triisopropylbenzenesulfonyl Chloride >97.0%(T) | 6553-96-4 | 25g | $21 | 2026-04-30 | Buy |
| TCI Chemical | T0459 | 2,4,6-Triisopropylbenzenesulfonyl Chloride >97.0%(T) | 6553-96-4 | 500g | $269 | 2026-04-30 | Buy |
| Usbiological | 230940 | 2,4,6-Triisopropylbenzenesulfonyl chloride 99+% ≥99%(Titration) | 6553-96-4 | 5g | $156 | 2026-06-03 | Buy |
2,4,6-Triisopropylbenzenesulfonyl chloride Chemical Properties,Uses,Production
Chemical Properties
White to cream solid
Uses
2,4,6-Triisopropylbenzenesulfonyl chloride can be used in the analysis of phosphonolipids in eggyolk by HPLC/MS technique.
It can also be used to synthesize:
- Dimeric neomycin-neomycin conjugate with a flexible linker, 2,2′-(ethylenedioxy)bis(ethylamine).
- Coupling reagents for the synthesis of oligonucleotides.
- Sulfonates of pyrimidine nucleosides. These sulfonates can be displaced by nucleophiles in the presence of palladium-catalysts.
Uses
2,4,6-Triisopropylbenzenesulfonyl chloride is used for the synthesis of glycerophospholipids as a condensing agent and in the analysis of phosphonolipids in egg yolk by HPLC/MS technique. It acts as a coupling reagent for the synthesis of oligonucleotides and as sulfonates of pyrimidine nucleosides. It also serves as a condensing agent in the synthesis of hydrogen-phosphonate diesters.
Synthesis
1) 1000mL four-necked bottle, add 2,4,6-triisopropylbenzene 72.0g, add sodium sulfate 3.6g under stirring, ice bath cooling to below 5 , control the reaction temperature of 5-15 , control 1.5-2.0 hours, from the dropping funnel slowly added primary chlorosulfuric acid 77.0g, add the graduation, at 10-15 holding reaction 0.5 hours.
2) control the reaction temperature for 15-25 , control 0.5-1.0 hours, from the drop funnel slowly add 145.0g of secondary chlorosulfonic acid, add, at 20-25 insulation reaction 2.0 hours to produce sulfonated material;
3) 1000mL beaker, add 150g of ice and water mixture, start stirring, the above sulfonated material slowly added to the ice and water, at 15 below the role of 15 minutes to maintain the material placed in the liquid funnel static for 30 minutes, separated out the lower organic layer of the system 2,4,6-triisopropylbenzenesulfonyl chloride 128.8g, yield 98.3%.
2,4,6-Triisopropylbenzenesulfonyl chloride Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
Global( 318)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Highfine Biotech Co.,Ltd. | +86-0512-68071238 +86-13771819922 | june@highfine.com | China | 491 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 | sales@amoychem.com | China | 6366 | 58 |
View Lastest Price from 2,4,6-Triisopropylbenzenesulfonyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-09 | 2,4,6-Triisopropylbenzenesulfonyl chloride
6553-96-4
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-05-28 | 2, 4, 6-Triisopropylbenzenesulfonyl Chloride
6553-96-4
|
$10.70 | 10KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2025-05-23 | 2, 4, 6-Triisopropylbenzenesulfonyl Chloride
6553-96-4
|
$10.00 | 1kg | 99% | 20 ton | Hebei Zhuanglai Chemical Trading Co Ltd |
-
- 2,4,6-Triisopropylbenzenesulfonyl chloride
6553-96-4
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2, 4, 6-Triisopropylbenzenesulfonyl Chloride
6553-96-4
- $10.70
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 2, 4, 6-Triisopropylbenzenesulfonyl Chloride
6553-96-4
- $10.00
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
2,4,6-Triisopropylbenzenesulfonyl chloride Spectrum
2,4,6-Triisopropylbenzenesulfonyl chloride(6553-96-4)MS2,4,6-Triisopropylbenzenesulfonyl chloride(6553-96-4)1HNMR2,4,6-Triisopropylbenzenesulfonyl chloride(6553-96-4)13CNMR2,4,6-Triisopropylbenzenesulfonyl chloride(6553-96-4)IR12,4,6-Triisopropylbenzenesulfonyl chloride(6553-96-4)IR22,4,6-Triisopropylbenzenesulfonyl chloride(6553-96-4)IR32,4,6-Triisopropylbenzenesulfonyl chloride(6553-96-4)Raman
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2,4,6-Triisopropylbenzenesulfonyl Chloride >
2,4,6-Triisopropylbenzenesulfonyl chloride ISO 9001：2015 REACH
Trisyl chloride
2,,6-Triisopropylbenzenesulfonyl chloride
2,4,6-TRIISOPROPYLBENZENESULFONYL CHLORIDE
2,4,6-Triisopropylbenzenesulphonyl chloride TPSCl
2,4,6-triaisopropylbenzenesulfonyl chloride
TSC (Triisopropylbenzene sulfulryl chloride), 98%
2,4,6-Tris(isopropyl)benzenesulphonyl chloride
2,4,6-Triisopropylbenzenesulf
TPS
2,4,6-tris(propan-2-yl)benzene-1-sulfonyl chloride
2,4,6-Tris(1-methylethyl)benzenesulfonyl chloride
2,4,6-Triisopropylbenzene-1-sulfonyl chloride
2,4,6-Triisopropylphenylsulfonyl chloride
TPSCL
6553-96-4
C15H23SO2Cl
C15H23ClO2S
CH32CH3C6H2SO2Cl
Building Blocks
SULFONYL CHLORIDE
Condensation & Active Esterification
DNA / RNA Synthesis
Condensing Agents (DNA / RNA Synthesis)
Sulfur Compounds (for Synthesis)
Sulfonyl Halides
Sulfur Compounds
Organic Building Blocks
API intermediates
Biochemistry
Condensation & Active Esterification
