2-Bromo-3-fluoro-6-picoline
- CAS No.
- 374633-36-0
- Chemical Name:
- 2-Bromo-3-fluoro-6-picoline
- Synonyms
- 2-bromo-3-fluoro-6-methylpyridine;2-Bromo-3-fL;uoro-6-methyL;6-Bromo-5-fluoro-2-picoline;2-BROMO-3-FLUORO-6-PICOLINE;Pyridine, 2-bromo-3-fluoro-6-methyl-;2-Bromo-3-fluoro-6-methylpyridine,98%;2-BROMO-3-FLUORO-6-PICOLINE ISO 9001：2015 REACH
- CBNumber:
- CB5252466
- Molecular Formula:
- C6H5BrFN
- Molecular Weight:
- 190.01
- MDL Number:
- MFCD03095061
- MOL File:
- 374633-36-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Bromo-3-fluoro-6-methylpyridine Aldrich | AGN00010 | 1g | $352 |
| 2-Bromo-3-fluoro-6-methylpyridine Asreported | 262040 | 25g | $917 |
| 2-Bromo-3-fluoro-6-methylpyridine Asreported | 262040 | 50g | $1359 |
| 2-Bromo-3-fluoro-6-methylpyridine Asreported | 262040 | 100g | $1876 |
| 2-Bromo-3-fluoro-6-methylpyridine Asreported | 262040 | 250g | $3433 |
| More product size | |||
| Boiling point | 185.6±35.0 °C(Predicted) |
|---|---|
| Density | 1.592±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | -0.91±0.10(Predicted) |
| form | Solid |
| Appearance | White to light yellow Solid |
| InChI | InChI=1S/C6H5BrFN/c1-4-2-3-5(8)6(7)9-4/h2-3H,1H3 |
| InChIKey | KKVUMKHUMBXLMH-UHFFFAOYSA-N |
| SMILES | C1(Br)=NC(C)=CC=C1F |
| CAS DataBase Reference | 374633-36-0(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H312-H315-H319-H332-H335-H302 | |||||||||
| Precautionary statements | P261-P280-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 2933499090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
2-Bromo-3-fluoro-6-picoline price More Price(85)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | AGN00010 | 2-Bromo-3-fluoro-6-methylpyridine Aldrich | 374633-36-0 | 1g | $352 | 2026-04-30 | Buy |
| Usbiological | 262040 | 2-Bromo-3-fluoro-6-methylpyridine Asreported | 374633-36-0 | 25g | $917 | 2026-06-03 | Buy |
| Usbiological | 262040 | 2-Bromo-3-fluoro-6-methylpyridine Asreported | 374633-36-0 | 50g | $1359 | 2026-06-03 | Buy |
| Usbiological | 262040 | 2-Bromo-3-fluoro-6-methylpyridine Asreported | 374633-36-0 | 100g | $1876 | 2026-06-03 | Buy |
| Usbiological | 262040 | 2-Bromo-3-fluoro-6-methylpyridine Asreported | 374633-36-0 | 250g | $3433 | 2026-06-03 | Buy |
2-Bromo-3-fluoro-6-picoline Chemical Properties,Uses,Production
Uses
2-Bromo-3-fluoro-6-methylpyridine is used as an intermediate in organic synthesis and pesticides.
Synthesis
3-Amino-2-bromo-6-methylpyridine or 4-amino-2-bromo-6-methylpyridine (25.20 g, 134.73 mmol) was added to a mixture of water (78.1 mL) and conc. HCl (12.8 mL, 350.30 mmol), and then the mixture was cooled to 0 ℃. To it, sodium nitrite (18.6 g,269.46 mmol) was added portion-wise with stirring over 20 min while keeping the reaction temperature between –5 ℃and 0 ℃. After 10 min, 65 per cent hexafluorophosphoric acid solution (43.26 g, 296.41 mmol) was added dropwise with cooling, at which point many precipitates were formed. The precipitates were collected by filtration using a glass filter funnel, washed with cold water (2 × 50 mL) and diethyl ether (100 mL), and then dried in the air for 48 h. The solid was slowly heated to 100 ℃ (very exothermic), and a dark, oily material was formed after 10 min. The oil was basified with diluted NaOH solution to pH~10 and extracted with CH2Cl2 (2 × 150 mL). The combined organic layer was dried over anhydrous Na2SO4, filtered, and evaporated to dryness under reduced pressure. The residue was purified by MPLC on neutral alumina using hexane/EtOAc (10:1) as an eluent to afford 2-Bromo-3-fluoro-6-picoline.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 22, p. 5228 - 5231
2-Bromo-3-fluoro-6-picoline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 | sales@amoychem.com | China | 6366 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 |
View Lastest Price from 2-Bromo-3-fluoro-6-picoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 2-BROMO-3-FLUORO-6-PICOLINE
374633-36-0
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2021-07-13 | 2-BROMO-3-FLUORO-6-PICOLINE
374633-36-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-11 | 2-BROMO-3-FLUORO-6-PICOLINE
374633-36-0
|
$3.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 2-BROMO-3-FLUORO-6-PICOLINE
374633-36-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-BROMO-3-FLUORO-6-PICOLINE
374633-36-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-BROMO-3-FLUORO-6-PICOLINE
374633-36-0
- $3.00
- 99%
- Career Henan Chemical Co
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