GSK269962A
- CAS No.
- 850664-21-0
- Chemical Name:
- GSK269962A
- Synonyms
- N-(3-((2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl)oxy)phenyl)-4-(2-morpholinoethoxy)benzamide;CS-1126;GSK 269962;GSK269962B;GSK-269962 95%;GSK269962A(GSK269962);GSK269962 (GSK269962A);GSK269962A/GSK 269962A;ROCK inhibitor GS269962A;ROCK inhibitor GSK269962A
- CBNumber:
- CB52546776
- Molecular Formula:
- C29H30N8O5
- Molecular Weight:
- 570.6
- MDL Number:
- MFCD09970310
- MOL File:
- 850664-21-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| GSK269962 ≥95% | 19180 | 1mg | $41 |
| GSK269962 ≥95% | 19180 | 5mg | $178 |
| GSK269962 ≥95% | 19180 | 10mg | $312 |
| GSK269962 ≥95% | 19180 | 25mg | $680 |
| GSK269962 ≥95% | 19180 | 1mg | $37 |
| More product size | |||
| Melting point | 125 - 127°C |
|---|---|
| Density | 1.45 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.19±0.70(Predicted) |
| color | Off-White |
| FDA UNII | F89KMM7TE2 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
GSK269962A price More Price(77)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19180 | GSK269962 ≥95% | 850664-21-0 | 1mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 19180 | GSK269962 ≥95% | 850664-21-0 | 5mg | $178 | 2026-04-30 | Buy |
| Cayman Chemical | 19180 | GSK269962 ≥95% | 850664-21-0 | 10mg | $312 | 2026-04-30 | Buy |
| Cayman Chemical | 19180 | GSK269962 ≥95% | 850664-21-0 | 25mg | $680 | 2026-04-30 | Buy |
| Cayman Chemical | 19180 | GSK269962 ≥95% | 850664-21-0 | 1mg | $37 | 2024-03-01 | Buy |
GSK269962A Chemical Properties,Uses,Production
Description
Two Rho-associated kinases (ROCKS), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. GSK269962 is a selective ROCK inhibitor with IC50 values of 1.6 and 6 nM for ROCK1 and ROCK2, respectively. It displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. GSK269962 has been shown to block the generation of inflammatory cytokines in lipopolysaccharide-stimulated monocytes and to induce vasorelaxation in preconstricted rat aorta (IC50 = 35 nM). Oral administration of 1-30 mg/kg GSK269962 can dose-dependently lower blood pressure in spontaneously hypertensive rats.
Uses
GSK 269962 is a potent and selective Rho kinase (ROCK) inhibitor.
in vivo
GSK269962A is a potent antihypertensive agent. GSK269962A (0.3, 1, and 3 mg/kg; oral gavage) induces a dose-dependent reduction in blood pressure in spontaneously hypertensive rat (SHR). The reduction of blood pressure is acute and substantial[1].
| Animal Model: | Male Sprague-Dawley rats (350-400g)[1] |
| Dosage: | 0.3, 1, and 3 mg/kg |
| Administration: | Oral gavage; 12 hours |
| Result: | Induced a dose-dependent reduction in blood pressure. |
IC 50
ROCK1: 1.6 nM (IC50); ROCK2: 4 nM (IC50); RSK1: 132 nM (IC50); MSK1: 49 nM (IC50); AKT1: 955 nM (IC50); AKT2: 1350 nM (IC50); AKT3: 1510 nM (IC50); CDK2: 3500 nM (IC50); GSK3α: 1260 nM (IC50)
storage
Store at +4°C
References
[1] CHRIS DOE. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities.[J]. Journal of Pharmacology and Experimental Therapeutics, 2007, 320 1: 89-98. DOI: 10.1124/jpet.106.110635
GSK269962A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9996 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-18712993135 | sales01@tairunfaz.com | China | 8051 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
View Lastest Price from GSK269962A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | GSK269962A
850664-21-0
|
$36.00-123.00 | 99.65% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-06-25 | GSK269962A
850664-21-0
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
![N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c] pyridin-6-yl]oxy}phenyl)-4-[2-(4-morpholinyl)ethoxy]benzamide pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/35a3e43e-66d0-4062-a2d4-04b7bdec5403.png) |
2020-01-02 | N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c] pyridin-6-yl]oxy}phenyl)-4-[2-(4-morpholinyl)ethoxy]benzamide
850664-21-0
|
$1.00 | 1KG | Min98% HPLC | Career Henan Chemical Co |
-
- GSK269962A
850664-21-0
- $36.00-123.00
- 99.65%
- TargetMol Chemicals Inc.
-
- GSK269962A
850664-21-0
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c] pyridin-6-yl]oxy}phenyl)-4-[2-(4-morpholinyl)ethoxy]benzamide
850664-21-0
- $1.00
- Min98% HPLC
- Career Henan Chemical Co
