2,4-Dichloro-5-fluoroacetophenone
- CAS No.
- 704-10-9
- Chemical Name:
- 2,4-Dichloro-5-fluoroacetophenone
- Synonyms
- 1-(2,4-DICHLORO-5-FLUOROPHENYL)ETHAN-1-ONE;1-(2,4-DICHLORO-5-FLUORO-PHENYL)-ETHANONE;2,4-Dichloro-5-fluor;2,4-dichloro-5-fluoroben;Ciprofloxacin Impurity 18;2',4'-Dichloro-5'-Fluoroacet;2,4- Dichloro -5-fluorohypnone;2,4-DICHLORO-5-FLUOROACETOPHENONE;2,4-Dichloro-5-flouroacetophenone;2,4-Dichloro-5-fluorobenzophenone
- CBNumber:
- CB6118080
- Molecular Formula:
- C8H5Cl2FO
- Molecular Weight:
- 207.03
- MDL Number:
- MFCD00077499
- MOL File:
- 704-10-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2′,4′-Dichloro-5′-fluoroacetophenone 90% | 457345 | 5g | $30 |
| 2',4'-Dichloro-5'-fluoroacetophenone | D2385 | 25g | $26 |
| 2',4'-Dichloro-5'-fluoroacetophenone Asreported | 273508 | 100g | $389 |
| 2',4'-Dichloro-5'-fluoroacetophenone 98% | PC2398E | 25g | $21 |
| 2',4'-Dichloro-5'-fluoroacetophenone 98% | PC2398E | 100g | $35 |
| More product size | |||
| Melting point | 33-36 °C |
|---|---|
| Boiling point | 167 °C(lit.) |
| Density | 1.425 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| color | White to Almost white |
| Specific Gravity | 1.425 |
| BRN | 3090042 |
| InChI | InChI=1S/C8H5Cl2FO/c1-4(12)5-2-8(11)7(10)3-6(5)9/h2-3H,1H3 |
| InChIKey | FAKJFAMIABOKBW-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC(F)=C(Cl)C=C1Cl)C |
| CAS DataBase Reference | 704-10-9(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,F | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Flammable | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29147000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2,4-Dichloro-5-fluoroacetophenone price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 457345 | 2′,4′-Dichloro-5′-fluoroacetophenone 90% | 704-10-9 | 5g | $30 | 2023-06-20 | Buy |
| TCI Chemical | D2385 | 2',4'-Dichloro-5'-fluoroacetophenone | 704-10-9 | 25g | $26 | 2026-04-30 | Buy |
| Usbiological | 273508 | 2',4'-Dichloro-5'-fluoroacetophenone Asreported | 704-10-9 | 100g | $389 | 2026-06-03 | Buy |
| Apolloscientific | PC2398E | 2',4'-Dichloro-5'-fluoroacetophenone 98% | 704-10-9 | 25g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC2398E | 2',4'-Dichloro-5'-fluoroacetophenone 98% | 704-10-9 | 100g | $35 | 2026-06-04 | Buy |
2,4-Dichloro-5-fluoroacetophenone Chemical Properties,Uses,Production
Application
2,4-Dichloro-5-fluoroacetophenone is an important chemical raw material used as a pharmaceutical intermediate. It is a major intermediate for the third-generation broad-spectrum and highly effective quinolone antibacterial agents ciprofloxacin and enrofloxacin.
Chemical Properties
white to light yellow cryst. low melting solid
Synthesis
1435-48-9
75-36-5
704-10-9
In a 1000 mL four-necked flask, 15 g (0.091 mol) of 2,4-dichlorofluorobenzene was added and cooled to 20°C. The solution was then purified with aluminum chloride. Subsequently, 200.2 g (1.5 mol) of aluminum chloride was added, the temperature was maintained between 20-30°C, and 78.5 g (1.0 mol) of acetyl chloride was slowly added dropwise, with the dropwise process being controlled to be completed in 2 to 3 hours. The reaction mixture was gradually heated to 40°C and maintained for 30 minutes, then slowly warmed to 70°C and maintained for 1~2 hours. Then, the heating was continued slowly to 110°C and the reaction was carried out at 110±2°C for 3~4 hours. After the reaction was completed, it was cooled to room temperature, 500 g of 5% hydrochloric acid solution was added and hydrolyzed at 80~90°C for 2~3 hours. After the hydrolysis product was washed to neutral, the organic phase was separated and purified by secondary distillation and recrystallization to obtain 168 g of 2',4'-dichloro-5'-fluoroacetophenone with a purity of 99.8% and a yield of 89.3%.
References
[1] Patent: CN102249881, 2016, B. Location in patent: Paragraph 0020; 0082-0083
[2] Tetrahedron Letters, 2009, vol. 50, # 21, p. 2525 - 2528
[3] Patent: WO2010/58421, 2010, A2. Location in patent: Page/Page column 20-21
[4] Patent: US6967205, 2005, B1. Location in patent: Page/Page column 25-26
2,4-Dichloro-5-fluoroacetophenone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Tianjin Zhongxin Chemtech Co., Ltd. | 86-22-66880623 +8618622897568 | sales@tjzxchem.com | China | 572 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 923 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 | sales@amoychem.com | China | 6366 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 |
View Lastest Price from 2,4-Dichloro-5-fluoroacetophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-09 | 1-(2,4-Dichloro-5-fluorophenyl)ethanone
704-10-9
|
$9.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 2,4-Dichloro-5-fluoroacetophenone
704-10-9
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-04-04 | 2,4-Dichloro-5-fluoroacetophenone
704-10-9
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 1-(2,4-Dichloro-5-fluorophenyl)ethanone
704-10-9
- $9.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2,4-Dichloro-5-fluoroacetophenone
704-10-9
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2,4-Dichloro-5-fluoroacetophenone
704-10-9
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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