ChemicalBook >> CAS DataBase List >>2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos
2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos
- CAS No.
- 1070663-78-3
- Chemical Name:
- 2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos
- Synonyms
- BRETTPHOS;dicyclohexyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphane;dicyclohexyl[3,6-dimethoxy-2',4',6'-tris(propan-2-yl)-[1,1'-biphenyl]-2-yl]phosphane;2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl;dicyclohexyl-[3,6-dimethoxy-2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane;Dicyclohexyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine;BrettPhos 96%;Brettphos Ligand;BrettPhos ChemBeads;-3,6-dimethoxybiphenyL
- CBNumber:
- CB62129176
- Molecular Formula:
- C35H53O2P
- Molecular Weight:
- 536.77
- MDL Number:
- MFCD11973797
- MOL File:
- 1070663-78-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 02:57:41
| Product description | Number | Pack Size | Price |
| BrettPhos 96% | 718742 | 1g | $195 |
| BrettPhos 96% | 718742 | 5g | $824 |
| Dicyclohexyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine | D5664 | 250MG | $81 |
| 2-(Dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos min.98% | 15-1152 | 250mg | $51 |
| 2-(Dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos min.98% | 15-1152 | 1g | $164 |
| More product size | |||
2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos Properties
| Melting point | 191-193℃ |
|---|---|
| Boiling point | 607.7±55.0 °C(Predicted) |
| storage temp. | Refrigerator, under inert atmosphere |
| solubility | Chloroform (Slightly), Methanol (Slightly, Sonicated) |
| form | crystal |
| color | white |
| InChI | 1S/C35H53O2P/c1-23(2)26-21-29(24(3)4)33(30(22-26)25(5)6)34-31(36-7)19-20-32(37-8)35(34)38(27-15-11-9-12-16-27)28-17-13-10-14-18-28/h19-25,27-28H,9-18H2,1-8H3 |
| InChIKey | WDVGNXKCFBOKDF-UHFFFAOYSA-N |
| SMILES | P(C1CCCCC1)(C1CCCCC1)C1=C(OC)C=CC(OC)=C1C1=C(C(C)C)C=C(C(C)C)C=C1C(C)C |
| FDA UNII | 4NJ39STQ41 |
| UNSPSC Code | 12352112 |
| NACRES | NA.82 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338-P304+P340-P405-P501A | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37-60 | |||||||||
| WGK Germany | nwg | |||||||||
| TSCA | No | |||||||||
| HS Code | 2931499090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos price More Price(84)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 718742 | BrettPhos 96% | 1070663-78-3 | 1g | $195 | 2026-04-30 | Buy |
| Sigma-Aldrich | 718742 | BrettPhos 96% | 1070663-78-3 | 5g | $824 | 2026-04-30 | Buy |
| TCI Chemical | D5664 | Dicyclohexyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine | 1070663-78-3 | 250MG | $81 | 2026-04-30 | Buy |
| Strem Chemicals | 15-1152 | 2-(Dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos min.98% | 1070663-78-3 | 250mg | $51 | 2026-04-30 | Buy |
| Strem Chemicals | 15-1152 | 2-(Dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos min.98% | 1070663-78-3 | 1g | $164 | 2026-04-30 | Buy |
2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos Chemical Properties,Uses,Production
Reactions
- Ligand for palladium-catalyzed cross-coupling reactions using aryl mesylates with electron-deficient anilines.
- Ligand for palladium-catalyzed cross-coupling of primary arylamines at low catalyst loading.
- Ligand for palladium-catalyzed cross-coupling of aryl iodides and primary amines.
- Ligand for the Suziki-Miyaura coupling of tosylates and mesylates.
- Ligand for the palladium-catalyzed trifluoromethylation of aryl chlorides.
- Ligand for the palladium-catalyzed formation of aryl-SCF3 compounds from aryl bromides.
- Ligand for the nickel-catalyzed cross-coupling of styrenyl epoxides with boronic acids.
- Ligand for the palladium-catalyzed intramolecular CH difluoroalkylation.
Uses
Ligand for the Suziki-Miyaura coupling of tosylates and mesylates.
Uses
reaction suitability
reagent type: catalyst
reaction type: Cross Couplings
Synthesis
1070663-76-1
16523-54-9
1070663-78-3
Example 2: General procedure for the synthesis of compounds 1 to 5; A 25 mL round bottom flask was dried in an oven equipped with a magnetic stir bar and 2-iodo-2',4',6'-triisopropyl-3,6-dimethoxy-1,1'-biphenyl (1 g, 2.15 mmol) was added. The flask was evacuated and backfilled with argon and the process was repeated three times. Anhydrous THF (10 mL) was added via syringe and the reaction mixture was cooled to -78 °C. Over 10 min, n-butyllithium (2.5 M hexane solution, 940 μL, 2.36 mmol) was added dropwise. After stirring the reaction mixture for 30 min, dicyclohexylphosphonium chloride (2.26 mmol) was added dropwise over 10 min. Stirring was continued at -78 °C for 1 h. The mixture was then slowly warmed to room temperature and stirred for an additional 1.5 h. The reaction mixture was then stirred for 1.5 h. The reaction mixture was then heated to room temperature. The reaction mixture was filtered through a diatomaceous earth plug, which was pre-placed on silica (eluting with ethyl acetate). The filtrate was concentrated on a rotary evaporator to give a white solid. The crude product was recrystallized by acetone (ligands 2 to 5 were recrystallized by methanol) to give white crystals of the target product 2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl.
References
[1] Journal of the American Chemical Society, 2008, vol. 130, # 41, p. 13552 - 13554
[2] Patent: WO2009/76622, 2009, A2. Location in patent: Page/Page column 115-116
2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 256)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| XINXIANG RUNYU MATERIAL CO., LTD. | +86-13592593621; +8613592593621 | sales@runvmat.com | China | 460 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8740 | 58 |
| Hangzhou Verychem Science And Technology Co.Ltd | +86-86-57188162785 13606544505 | lucy@verychem.com | China | 1201 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14014 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21586 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| AB PharmaTech,LLC | 323-480-4688 | sales@acrospharmatech.com | United States | 989 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
View Lastest Price from 2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-15 | 2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl
1070663-78-3
|
$130.00-1185.00 | 5g | 0.98 | 1kg | Shanghai UCHEM Inc. | |
 |
2025-04-11 | 2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl
1070663-78-3
|
$790.00 | 1g | 99 % | 5000 Kg | R&D Scientific Inc. | |
 |
2024-08-29 | 2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl
1070663-78-3
|
1kg | 0.99 | 1 tons | Hangzhou Verychem Science And Technology Co.Ltd |
-
- 2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl
1070663-78-3
- $130.00-1185.00
- 0.98
- Shanghai UCHEM Inc.
-
- 2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl
1070663-78-3
- $790.00
- 99 %
- R&D Scientific Inc.
-
- 2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl
1070663-78-3
- $0.00
- 0.99
- Hangzhou Verychem Science And Technology Co.Ltd
2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos Spectrum
2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos(1070663-78-3)1HNMR2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos(1070663-78-3)31PNMR2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos(1070663-78-3)FT-IR
1070663-78-3(2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos)Related Search:
X-PHOS
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
2-DICYCLOHEXYLPHOSPHINO-2',6'-DIISOPROPOXYBIPHENYL
2-(Diphenylphosphino)-biphenyl
2-(Diphenylphosphino)benzoic acid
2-(Dicyclohexylphosphino)biphenyl
2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL
2-(Dicyclohexylphosphino)-2'-methoxybiphenyl
2'-(dicyclohexylphosphino)-6-methoxy-N,N-dimethylbiphenyl-2-amine
2-(Dicyclohexylphosphino)-2'-methylbiphenyl
1of4
2-(Dicyclohexylphosphino)-3,6-diMethoxy-2'-4' -6'-tri-i-propyl-1,1'-biphenyl
2-Dicyclohexylphosphino-2',4',6'-triisopropyl-3,6-diMethoxybiphenyl, 97+%
2-Dicyclohexylphosphino-2',4',6'-tri-i-propyl-3,6-diMethoxy-1,1'-biphenyl, 98% (BrettPhos)
BrettPhos 96%
2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos
2-(Dicyclohexylphosphino)3,6-dimethoxy-2′,4′,6′-triisopropyl-1,1′-biphenyl
Dicyclohexyl[3,6-dimethoxy-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine
2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl(BrettPhos)
2-(Dicyclohexylphosphino)-3,6-diMethoxy-2'-4'-6'-tri-i-propyl-1,1'
2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-bipheny
2-Dicyclohexylphosphino-2',4',6'-triisopropyl-3,6-dimethoxybiphenyl
2-(Dicyclohexyl phosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenly
2-Dicyclohexylphosphino-2',4',6'-tri-i-propyl-3,6-dimethoxy-1,1'-biphenyl, (BrettPhos)
BrettPhos / 2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl
2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. BrettPhos
Dicyclohexyl(2',4',6'-tri
Phosphine, dicyclohexyl[3,6-dimethoxy-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]-
-3,6-dimethoxybiphenyL
icyclohexyl-[3,6-dimethoxy-2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane
2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos ISO 9001：2015 REACH
2-Dicyclohexylphosphino-3,6-dimethoxy-2',4',61-trisopropyl-1,1'-biphenyl(Brettphos)
high purity 1070663-78-3 in China /2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl good supplier
dicyclohexyl-[3,6-dimethoxy-2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane
2-Dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl -1,1' -biphenyl
(BrettPhos)
2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min
Dicyclohexyl-[3,6-dimethoxy-2-[2,4,6-tri(propan-2-yl) phenyl]phenyl]phosphane (Brettphos)
Brettphos Ligand
2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl (BRETTPHOS)Brettphos
2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl( BrettPhos)
Dicydohexyl(2',4,6'-trisopropyl-3,6-dimethoxy-[1,1'-biphenyl] -2-yl)phosphine
2-(Dicyclohexylphosphino)-2’,4’,6’-triisopropyl-3,6-dimethoxybiphenyl
BrettPhos ChemBeads
2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-1-propyl-11'-biphenyl
2-Cyclohexylphosphine-3,6-dimethoxy-2',4',6'-tripropyl-1,1'-biphenyl
2-(Dicyclohexylphosphoryl)-3,6-dimethoxy-2',4',6'-tripropyl-1,1'-biphenyl
2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl
BRETTPHOS
dicyclohexyl[3,6-dimethoxy-2',4',6'-tris(propan-2-yl)-[1,1'-biphenyl]-2-yl]phosphane
dicyclohexyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphane
Dicyclohexyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine
1070663-78-3
1070963-78-3
C35H53O2P
Achiral Phosphine
Aryl Phosphine
Buchwald Ligands Series
Buchwald Ligands&Precatalysts
