5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
- CAS No.
- 42518-98-9
- Chemical Name:
- 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
- Synonyms
- Rivaroxabansidechain;5-Chorothiophene-2-carbonyl chloride;2-thiophenecarbonyl chloride, 5-chloro-;2-Amino-10-picoline;orothiophene-2-carbonyL;Rivaroxaban Impurity 82;Rivaroxaban Impurity 102;Rivaroxaban Impurity 103;5-Chloro-2-thenoyl Chloride;5-Chlorothieno-2-formyl chloride
- CBNumber:
- CB6290784
- Molecular Formula:
- C5H2Cl2OS
- Molecular Weight:
- 181.04
- MDL Number:
- MFCD00043886
- MOL File:
- 42518-98-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Chlorothiophene-2-carbonyl Chloride >98.0%(GC)(T) | C2864 | 5g | $23 |
| 5-Chlorothiophene-2-carbonyl Chloride >98.0%(GC)(T) | C2864 | 25g | $68 |
| 5-Chlorothiophene-2-carbonyl chloride ≥98%(GC) | 44975 | 5G | $43.06 |
| 5-Chlorothiophene-2-carbonyl chloride ≥98%(GC) | 44975 | 25G | $140.41 |
| 5-Chlorothiophene-2-carbonyl chloride | 061821 | 1.00g | $34 |
| More product size | |||
| Melting point | 4℃ |
|---|---|
| Boiling point | 122-127℃/16Torr |
| Density | 1.50 |
| refractive index | 1.6040 to 1.6080 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Oil |
| color | Colourless to Pale Yellow |
| Water Solubility | Slightly soluble in water. |
| Sensitive | Moisture Sensitive |
| Stability | Hygroscopic |
| InChI | InChI=1S/C5H2Cl2OS/c6-4-2-1-3(9-4)5(7)8/h1-2H |
| InChIKey | BMPDCQVRKDNUAP-UHFFFAOYSA-N |
| SMILES | C(Cl)(C1SC(Cl)=CC=1)=O |
| CAS DataBase Reference | 42518-98-9(CAS DataBase Reference) |
| FDA UNII | V8Z66S2CJ3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H318 | |||||||||
| Precautionary statements | P260h-P301+P330+P331-P303+P361+P353-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 36-43 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 3265 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C2864 | 5-Chlorothiophene-2-carbonyl Chloride >98.0%(GC)(T) | 42518-98-9 | 5g | $23 | 2026-04-30 | Buy |
| TCI Chemical | C2864 | 5-Chlorothiophene-2-carbonyl Chloride >98.0%(GC)(T) | 42518-98-9 | 25g | $68 | 2026-04-30 | Buy |
| Chem-Impex | 44975 | 5-Chlorothiophene-2-carbonyl chloride ≥98%(GC) | 42518-98-9 | 5G | $43.06 | 2026-05-19 | Buy |
| Chem-Impex | 44975 | 5-Chlorothiophene-2-carbonyl chloride ≥98%(GC) | 42518-98-9 | 25G | $140.41 | 2026-05-19 | Buy |
| Matrix Scientific | 061821 | 5-Chlorothiophene-2-carbonyl chloride | 42518-98-9 | 1.00g | $34 | 2026-05-18 | Buy |
5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Chemical Properties,Uses,Production
Chemical Properties
Colorless to light yellow liquid
Uses
5-Chlorothiophene-2-carbonyl chloride used as a intermediate for rivaroxaban.
Synthesis
6310-09-4
42518-98-9
General procedure for the synthesis of 5-chloro-2-thiophene carbonyl chloride from 2-acetyl-5-chlorothiophene: To a mixed solution containing 2-acetyl-5-chlorothiophene (0.161 mg, 1.0 mmol), pyridine (0.012 mL, 0.15 mmol), and chlorobenzene (0.35 mL), at room temperature, disulfur dichloride (S2Cl2, 0.16 mL 2.0 mmol) with continuous stirring. After 2 hours of reaction, sulfuryl chloride (SO2Cl2, 0.121 mL, 1.5 mmol) was added dropwise and stirring was continued for 0.5 hours at room temperature. Subsequently, the reaction mixture was heated to 132 °C and stirred at this temperature for 15 hours. Upon completion of the reaction, the reaction mixture was diluted with deuterated chloroform (CDCl3, 2 mL) and an internal standard (tributyl phosphate, 1BU3PO4, 0.0552 mL, 0.20 mmol) was added for nuclear magnetic resonance (1H NMR) analysis.1H NMR analysis showed an 80% yield of 5-chloro-2-thiophene carbonyl chloride.1H NMR (PhCl. CDCl3, 400 MHz) chemical shift values: δ = 7.99 (d, J = 4 Hz, 1H), 6.86 (d, J = 4 Hz, 1H).
References
[1] Patent: WO2017/5606, 2017, A1. Location in patent: Page/Page column 33
[2] Patent: WO2016/150937, 2016, A1. Location in patent: Page/Page column 27
[3] Recueil des Travaux Chimiques des Pays-Bas, 1950, vol. 69, p. 1083,1103
[4] Journal of Organic Chemistry, 2015, vol. 80, # 20, p. 10370 - 10374
[5] Patent: WO2016/202757, 2016, A1. Location in patent: Page/Page column 30
5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +8615350851019 | admin@86-ss.com | China | 999 | 58 |
| Handan City Zechi trading Co., LTD | +8619003396151 | 13165586887@163.com | China | 475 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 340 | 58 |
View Lastest Price from 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-01 | 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
42518-98-9
|
$750.00-980.00 | 1ton | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-05-15 | 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
42518-98-9
|
$365.00 | 1KG | 99% | 100kg | Baoji Guokang Healthchem Co., Ltd. | |
 |
2026-02-25 | 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
42518-98-9
|
$60.00-100.00 | 100kg | 99.99% | 100Tons | Hebei Dangtong Import and export Co LTD |
-
- 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
42518-98-9
- $750.00-980.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
42518-98-9
- $365.00
- 99%
- Baoji Guokang Healthchem Co., Ltd.
-
- 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
42518-98-9
- $60.00-100.00
- 99.99%
- Hebei Dangtong Import and export Co LTD
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