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N-Benzyloxycarbonyl-D-proline

N-Benzyloxycarbonyl-D-proline structure

CAS No.: 6404-31-5

Chemical Name:: N-Benzyloxycarbonyl-D-proline

Synonyms: Z-D-PRO-OH;N-CARBOBENZOXY-D-PROLINE;(R)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid;D-Z-PRO;Z-D-Pro;Cbz-D-Pro;Z-D-Pro-0H;PROLINA-Z-D;Z-D-PROLINE;CBZ-D-PRO-OH

CBNumber:: CB6295385

Molecular Formula:: C13H15NO4

Molecular Weight:: 249.26

MDL Number:: MFCD00063228

MOL File:: 6404-31-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:55:35

Product description	Number	Pack Size	Price
(+)-Z-D-proline 98%	860735	500MG	$63.9
N-Carbobenzoxy-D-proline >98.0%(HPLC)(T)	C1730	5g	$36
N-Carbobenzoxy-D-proline >98.0%(HPLC)(T)	C1730	25g	$103
N-(Benzyloxycarbonyl)-D-proline	457366	1g	$403
N-(Benzyloxycarbonyl)-D-proline	457366	10g	$531
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N-Benzyloxycarbonyl-D-proline Properties

Melting point	76-78 °C(lit.)
alpha	40 º (c=2, EtOH)
Boiling point	432.3±45.0 °C(Predicted)
Density	1.309±0.06 g/cm3(Predicted)
refractive index	40 ° (C=2, EtOH)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form	Crystalline Powder or Powder
pka	3.99±0.20(Predicted)
color	White
optical activity	[α]25/D +40.2°, c = 2 in ethanol
BRN	485188
InChI	InChI=1S/C13H15NO4/c15-12(16)11-7-4-8-14(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,15,16)/t11-/m1/s1
InChIKey	JXGVXCZADZNAMJ-LLVKDONJSA-N
SMILES	N1(C(OCC2=CC=CC=C2)=O)CCC[C@@H]1C(O)=O
CAS DataBase Reference	6404-31-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H335-H319-H302-H315-H332

Precautionary statements

P264-P280-P305+P351+P338-P337+P313P-P261-P271-P304+P340-P312-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501

Hazard Codes

Safety Statements

24/25

WGK Germany

HS Code

29339900

REACH Registrations

Active

NFPA 704

	1
1		0

N-Benzyloxycarbonyl-D-proline price More Price(89)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	860735	(+)-Z-D-proline 98%	6404-31-5	500MG	$63.9	2023-01-07	Buy
TCI Chemical	C1730	N-Carbobenzoxy-D-proline >98.0%(HPLC)(T)	6404-31-5	5g	$36	2026-04-30	Buy
TCI Chemical	C1730	N-Carbobenzoxy-D-proline >98.0%(HPLC)(T)	6404-31-5	25g	$103	2026-04-30	Buy
Usbiological	457366	N-(Benzyloxycarbonyl)-D-proline	6404-31-5	1g	$403	2026-06-03	Buy
Usbiological	457366	N-(Benzyloxycarbonyl)-D-proline	6404-31-5	10g	$531	2026-06-03	Buy

Product number	Packaging	Price	Buy
860735	500MG	$63.9	Buy
C1730	5g	$36	Buy
C1730	25g	$103	Buy
457366	1g	$403	Buy
457366	10g	$531	Buy

N-Benzyloxycarbonyl-D-proline Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder or powder

Uses

N-(Benzyloxycarbonyl)-D-proline is an an N-Cbz-protected form of D-proline (P755990). It is used to prepare trichostatin A and trapoxin B analogs as histone deacetylase inhibitors. It is also used to prepare potent and selective nonpeptide inhibitors of caspases 3 and 7.

Synthesis

501-53-1

344-25-2

6404-31-5

Step-1: Preparation of (R)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid (12a). To a stirred solution of D-proline (1.2 g, 10.42 mmol) in 2 N NaOH aqueous solution (20.85 mL, 41.7 mmol), benzyl chloroformate (1.488 mL, 10.42 mmol) was slowly added dropwise at 0°C. The reaction mixture was gradually warmed to room temperature and stirred overnight. Upon completion of the reaction, the reaction mixture was washed with methyl tert-butyl ether (MTBE, 2 × 25 mL) and then acidified with concentrated hydrochloric acid to pH ≈ 2. The aqueous phase was extracted with ethyl acetate (2 × 200 mL), and the organic phases were combined and washed sequentially with water (50 mL) and saturated saline (25 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford (R)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid (12a) (2.41 g, 9.67 mmol) as a white solid in 93% yield. The product was characterized by 1H NMR (300 MHz, DMSO-d6) and mass spectrometry (MS): 1H NMR δ 12.66 (s, 1H), 7.42-7.25 (m, 5H), 5.14-4.97 (m, 2H), 4.20 (ddd, J = 22.7, 8.8, 3.5 Hz, 1H), 3.50-3.25 (m, 2H), 2.32-2.08 (m, 1H), 1.97-1.75 (m, 3H); MS (ES+) m/z 250.2 ([M+H]+), 272.2 ([M+Na]+), (ES-) m/z 248.2 ([M-H]-), 284.2 ([M+Cl]-), 497.4 ([2M-H]-).

References

[1] Patent: WO2015/62486, 2015, A1. Location in patent: Paragraph 00191
[2] Patent: WO2017/59178, 2017, A1. Location in patent: Page/Page column 73
[3] Journal of Pharmaceutical Sciences, 1991, vol. 80, # 9, p. 837 - 842
[4] Angewandte Chemie - International Edition, 2006, vol. 45, # 28, p. 4593 - 4597
[5] European Journal of Medicinal Chemistry, 2009, vol. 44, # 7, p. 2807 - 2814

N-Benzyloxycarbonyl-D-proline Preparation Products And Raw materials

Raw materials

Benzyl chloroformate D-Valine D-Proline Sodium hydroxide

Preparation Products

(R)-5-BROMO-3-[(1-METHYL-2-PYRROLIDINYL)METHYL]-1H-INDOLE (2R)-N-Methyl-2-PyrrolidinecarboxaMide

N-Benzyloxycarbonyl-D-proline Suppliers

Global( 426)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
AB PharmaTech,LLC	323-480-4688	sales@acrospharmatech.com	United States	989	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Jinan Shengqi pharmaceutical Co,Ltd	86+18663751872	christine@shengqipharm.com	CHINA	491	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6366	58
Shanghai Longyu Biotechnology Co., Ltd.		info@longyupharma.com	China	2421	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
AB PharmaTech,LLC	55
career henan chemical co	58
Jinan Shengqi pharmaceutical Co,Ltd	58
Xiamen AmoyChem Co., Ltd	58
Shanghai Longyu Biotechnology Co., Ltd.	58
Alchem Pharmtech,Inc.	58
Shanghai Yingrui Biopharma Co.,Ltd	58

View Lastest Price from N-Benzyloxycarbonyl-D-proline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-08	N-Benzyloxycarbonyl-D-proline 6404-31-5		1KG	98%min	500kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2021-07-13	Z-D-Proline 6404-31-5	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09	Z-D-Proline 6404-31-5	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

N-Benzyloxycarbonyl-D-proline
6404-31-5
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Z-D-Proline
6404-31-5
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Z-D-Proline
6404-31-5
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

N-Benzyloxycarbonyl-D-proline Spectrum

N-Benzyloxycarbonyl-D-proline(6404-31-5)¹HNMR N-Benzyloxycarbonyl-D-proline(6404-31-5)Raman N-Benzyloxycarbonyl-D-proline(6404-31-5)IR

6404-31-5(N-Benzyloxycarbonyl-D-proline)Related Search:

Z-D-PYR-OH Ethyl 2-(Chlorosulfonyl)acetate L-PROLINE-(4-3H(N)) PYRAZOPHOS Hyaluronic acid

Trimethoprim L-Proline Folic acid N-Carbobenzyloxyglycine Pyrrolidine

D-Proline cis-4-Hydroxy-L-proline Z-GAMMA-ABU-OH Z-D-Pro-ONp Z-D-Pyr-Osu

Z-D-PRO-NH2 Z-D-PHE-ONP Z-D-PRO-OTBU

1of4

Cbz-D-Pro PROLINA-Z-D 1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(PHENYLMETHYL)ESTER, (2R)- 1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(PHENYLMETHYL) ESTER, (R)- 1-[(BENZYLOXY)CARBONYL]PYRROLIDINE-2-CARBOXYLIC ACID (R)-Z-pyrrolidine-2-carboxylic acid Z-D-proline≥ 98% (HPLC) BENZYLOXYCARBONYL-D-PROLINE D-Z-PRO (+)-CARBOBENZYLOXY-D-PROLINE (+)-Carbobenzyloxy-P-proline N-Benzyloxycarbonyl-D-proline ,99% Benzyloxycarbonyl-D-proline (Z-D-pro-OH) N-Cbz-D-proline Z-D-Pro-OH N-benzyloxycarbonyl-D-proline (KSM-I) CBZ-D-PROLINE CBZ-D-PRO-OH (R)-N-BENZYLOXYCARBONYLPROLINE N-ALPHA-CBZ-D-PROLINE N-ALPHA-BENZYLOXYCARBONYL-D-PROLINE N-ALPHA-CARBOBENZOXY-D-PYRROLIDINE-2-CARBOXYLIC ACID N-ALPHA-CARBOBENZOXY-D-PROLINE N-CBZ-D-PROLINE N-BENZYLOXYCARBONYLAMINO-D-PROLINE N-BENZYLOXYCARBONYL-D-PROLINE N-Z-D-PROLINE Z-D-PROLINE Z-D-PYRD(2)-OH 1-benzyl hydrogen (R)-pyrrolidine-1,2-dicarboxylate N-CBZ-D-PROLINE CRYSTALLINE N-Cbz-D-proline,98+% N-CBZ-D-PRO-OH N-CARBOBENZYLOXY-D-PROLINE N-Benzyloxycarbonyl-D-proline, 98+% Z-D-PROLINE extrapure (+)-Z-D-proline (2R)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid (2R)-1,2-Pyrrolidinedicarboxylic acid 1-benzyl ester 1-(Benzyloxycarbonyl)-D-proline Z-D-Pro N-Carbobenzoxy-D-proline > N-Cbz-D-ProL N-Benzyloxycarbonyl-D-proline [CBZ-D-Proline] N-Benzyloxycarbonyl-D-proline USP/EP/BP N-Cbz-D-proline, 98% [Z-D-Pro-OH] D-Cbz-Proline N-Benzyloxycarbonyl-D-proline, 95% Z-D-Pro-0H (R)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid N-CARBOBENZOXY-D-PROLINE Z-D-PRO-OH 6404-31-5 6404-31- 1144-21-2 Peptide Synthesis Specialty Synthesis Protected & Labeled Amino Acids Cbz-Amino Acids

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