ChemicalBook >> CAS DataBase List >>sbc-115076
sbc-115076
- CAS No.
- 489415-96-5
- Chemical Name:
- sbc-115076
- Synonyms
- CS-2068;CS-1638;sbc-115076;SBC-115076, 10 mM in DMSO;SBC-115076;SBC 115076;SBC115076;4-(4-(benzyloxy)-3-methylbenzoyl)-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-4-yl)-1,5-dihydro-2H-pyrrol-2-one;4-[hydroxy-(3-methyl-4-phenylmethoxyphenyl)methylidene]-1-(3-morpholin-4-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione;1,5-Dihydro-3-hydroxy-4-[3-methyl-4-(phenylmethoxy)benzoyl]-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-2H-pyrrol-2-one;2H-Pyrrol-2-one, 1,5-dihydro-3-hydroxy-4-[3-methyl-4-(phenylmethoxy)benzoyl]-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-;Inhibitor,inhibit,sensitivity,Ser/Thr Protease,LDL,HFD-fed,obesity,Serine proteases,rats,SBC 115076,SBC-115076,Threonine proteases,Serine endopeptidases,insulin
- CBNumber:
- CB63038769
- Molecular Formula:
- C31H33N3O5
- Molecular Weight:
- 527.61
- MDL Number:
- MFCD03296540
- MOL File:
- 489415-96-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 02:15:19
| Product description | Number | Pack Size | Price |
| SBC-115076 ≥98% (HPLC) | SML1712 | 5MG | $136 |
| SBC-115076 ≥98% | 19134 | 1mg | $36 |
| SBC-115076 ≥98% | 19134 | 5mg | $128 |
| SBC-115076 ≥98% | 19134 | 10mg | $203 |
| SBC-115076 ≥98% | 19134 | 25mg | $436 |
| More product size | |||
| Boiling point | 754.2±60.0 °C(Predicted) |
|---|---|
| Density | 1.266±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility |
DMSO:46.0(Max Conc. mg/mL);87.18(Max Conc. mM) DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.95(Max Conc. mM) DMF:2.0(Max Conc. mg/mL);3.79(Max Conc. mM) |
| form | A crystalline solid |
| pka | 4.50±1.00(Predicted) |
| color | White to off-white |
| SMILES | CC1=CC(C(C(C(C2=CC=NC=C2)N3CCCN4CCOCC4)=C(O)C3=O)=O)=CC=C1OCC5=CC=CC=C5 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
sbc-115076 price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1712 | SBC-115076 ≥98% (HPLC) | 489415-96-5 | 5MG | $136 | 2026-04-30 | Buy |
| Cayman Chemical | 19134 | SBC-115076 ≥98% | 489415-96-5 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 19134 | SBC-115076 ≥98% | 489415-96-5 | 5mg | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 19134 | SBC-115076 ≥98% | 489415-96-5 | 10mg | $203 | 2026-04-30 | Buy |
| Cayman Chemical | 19134 | SBC-115076 ≥98% | 489415-96-5 | 25mg | $436 | 2026-04-30 | Buy |
sbc-115076 Chemical Properties,Uses,Production
Uses
SBC-115,076 is an anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compound used in treatment and/or prevention of cardiovascular diseases and hypercholesterolemia.
Biological Activity
SBC-115076 is an inhibitor of PCSK9 (proprotein convertase subtilisin-kexin 9). PCSK9 binds to the LDL receptor, preventing it from removing LDL cholesterol from the blood. SBC-115076 was shown to inihbit PCSK9, blocking LDLR degradation in HEK293T cells expressing PCSK9 and to increase the uptake of LDL by liver cells in vitro. SBC-115076 lowered cholesterol levels in mice fed a high f at diet.
in vivo
SBC-115076 (4 mg/kg; s.c.; daily for 3 weeks) reduces obesity and dyslipidemia, as well as improves insulin sensitivity in HFD-fed rats[1].
| Animal Model: | Female Wistar rats (high-fat diet (HFD)- fed)[1] |
| Dosage: | 4 mg/kg |
| Administration: | S.c.; daily for 3 weeks |
| Result: | Superior to atorvastatin in instigating weight loss, cholesterol reduction, and attenuation of mitochondrial oxidative stress in oxidative muscle fibers of obese female rats. |
sbc-115076 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 80)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11680 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 |
View Lastest Price from sbc-115076 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | SBC-115076
489415-96-5
|
$34.00-77.00 | 99.39% | 10g | TargetMol Chemicals Inc. |
-
- SBC-115076
489415-96-5
- $34.00-77.00
- 99.39%
- TargetMol Chemicals Inc.
sbc-115076
4-[hydroxy-(3-methyl-4-phenylmethoxyphenyl)methylidene]-1-(3-morpholin-4-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione
1,5-Dihydro-3-hydroxy-4-[3-methyl-4-(phenylmethoxy)benzoyl]-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-2H-pyrrol-2-one
2H-Pyrrol-2-one, 1,5-dihydro-3-hydroxy-4-[3-methyl-4-(phenylmethoxy)benzoyl]-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-
CS-1638
CS-2068
SBC-115076;SBC 115076;SBC115076
4-(4-(benzyloxy)-3-methylbenzoyl)-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-4-yl)-1,5-dihydro-2H-pyrrol-2-one
Inhibitor,inhibit,sensitivity,Ser/Thr Protease,LDL,HFD-fed,obesity,Serine proteases,rats,SBC 115076,SBC-115076,Threonine proteases,Serine endopeptidases,insulin
SBC-115076, 10 mM in DMSO
489415-96-5
Inhibitors
