4-Chlorophenyl isocyanate
- CAS No.
- 104-12-1
- Chemical Name:
- 4-Chlorophenyl isocyanate
- Synonyms
- 1-Chloro-4-isocyanatobenzene;P-CHLOROPHENYL ISOCYANATE;PCPI;4-Chlorphenylisocyanate;4-ISOCYANATO CHLOROBENZENE;PARA CHLOROPHENYL ISOCYANATE;pcic;4-Chlorophenyl isocy;p-Chlorfenylisokyanat;4-Chlorphenylisocyanat
- CBNumber:
- CB6680525
- Molecular Formula:
- C7H4ClNO
- Molecular Weight:
- 153.57
- MDL Number:
- MFCD00002024
- MOL File:
- 104-12-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Chlorophenyl isocyanate 98% | 152277 | 5g | $59.5 |
| 4-Chlorophenyl isocyanate 98% | 152277 | 100g | $128 |
| 4-Chlorophenyl isocyanate Asreported | 267302 | 250g | $343 |
| 4-Chlorophenyl isocyanate Asreported | 267302 | 500g | $468 |
| 4-Chlorophenyl isocyanate Asreported | 267302 | 1kg | $612 |
| More product size | |||
| Melting point | 26-29 °C (lit.) |
|---|---|
| Boiling point | 203-204 °C (lit.) |
| Density | 1.2 g/mL at 25 °C (lit.) |
| vapor pressure | 30Pa at 20℃ |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly) |
| form | Crystalline Solid |
| color | White to yellow |
| Odor | sharp irritating odor |
| Water Solubility | DECOMPOSES |
| Sensitive | Moisture Sensitive/Lachrymatory |
| BRN | 386235 |
| Henry's Law Constant | 5.7×10-2 mol/(m3Pa) at 25℃, Zhang et al. (2010) |
| InChI | 1S/C7H4ClNO/c8-6-1-3-7(4-2-6)9-5-10/h1-4H |
| InChIKey | ADAKRBAJFHTIEW-UHFFFAOYSA-N |
| SMILES | Clc1ccc(cc1)N=C=O |
| LogP | 3.12 at 22℃ |
| CAS DataBase Reference | 104-12-1(CAS DataBase Reference) |
| EWG's Food Scores | 1-3 |
| FDA UNII | W46XL60WI8 |
| NIST Chemistry Reference | Benzene, 1-chloro-4-isocyanato-(104-12-1) |
| EPA Substance Registry System | p-Chlorophenyl isocyanate (104-12-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS05,GHS06,GHS08,GHS09 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H318-H330-H334-H335-H410 | |||||||||
| Precautionary statements | P260-P273-P280-P302+P352-P304+P340+P310-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T+,T,C | |||||||||
| Risk Statements | 25-26-37/38-41-42-52/53 | |||||||||
| Safety Statements | 23-26-28-36/37/39-45-61-38-37/39-28A-22 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NQ8575000 | |||||||||
| F | 10-19-21 | |||||||||
| Hazard Note | Toxic/Corrosive/Lachrymatory/Moisture Sensitive | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29291090 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Acute Tox. 2 Inhalation Acute Tox. 3 Oral Aquatic Acute 1 Aquatic Chronic 1 Eye Dam. 1 Resp. Sens. 1 Skin Irrit. 2 STOT SE 3 |
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| Hazardous Substances Data | 104-12-1(Hazardous Substances Data) | |||||||||
| Toxicity | mammal (species unspecified),LC50,inhalation,53mg/m3 (53mg/m3),Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 11(4), Pg. 23, 1967. | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 0.5 Kg (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
4-Chlorophenyl isocyanate price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 152277 | 4-Chlorophenyl isocyanate 98% | 104-12-1 | 5g | $59.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 152277 | 4-Chlorophenyl isocyanate 98% | 104-12-1 | 100g | $128 | 2026-04-30 | Buy |
| Usbiological | 267302 | 4-Chlorophenyl isocyanate Asreported | 104-12-1 | 250g | $343 | 2026-06-03 | Buy |
| Usbiological | 267302 | 4-Chlorophenyl isocyanate Asreported | 104-12-1 | 500g | $468 | 2026-06-03 | Buy |
| Usbiological | 267302 | 4-Chlorophenyl isocyanate Asreported | 104-12-1 | 1kg | $612 | 2026-06-03 | Buy |
4-Chlorophenyl isocyanate Chemical Properties,Uses,Production
Chemical Properties
white to yellow crystalline solid
Uses
4-Chlorophenyl isocyanate was used in the preparation of isothiocyanates.
Uses
4-Chlorophenyl isocyanate is used in the preparation of isothiocyanates. Aryl isocyanates undergo [2+2] cycloaddition reactions with dihydrofuran to give bicyclic -lactams in high yield.
Synthesis Reference(s)
The Journal of Organic Chemistry, 34, p. 3200, 1969 DOI: 10.1021/jo01262a089
General Description
Colorless to yellow liquid or crystals. Used as an intermediate in pesticide and pharmaceutical manufacture.
Reactivity Profile
Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].
Safety Profile
Poison by ingestion and inhalation. Unspecified human systemic effects. A severe eye and moderate skin irritant. A flammable liquid when exposed to heat or flame. Dangerous, can explode on distillation. When heated to decomposition it emits toxic fumes of Cl-, CN-, and NOx.
Purification Methods
Purify the isocyanate by recrystallisation from pet ether (b 30-40o) or better by fractional distillation. TOXIC irritant. [Beilstein 12 H 616, 12 III 1376, 12 IV 1213.]
4-Chlorophenyl isocyanate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Honest Joy Holdings Limited | +86-0755-36694831 13717124449 | sales@debayer.com | China | 300 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 | sales1@chuanghaibio.com | China | 5219 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | 0531-68652808 18953170293 | sales@sdzschem.com | China | 2921 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 | sales@amoychem.com | China | 6366 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
View Lastest Price from 4-Chlorophenyl isocyanate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-05-28 | 4-Chlorophenyl isocyanate
104-12-1
|
$10.00 | 1KG | 99.% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2025-04-04 | 4-Chlorophenyl isocyanate
104-12-1
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd.
|
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2024-04-23 | 4-Chlorophenyl isocyanate
104-12-1
|
$10.00 | 1kg | 99.6% | 100000 | Ouhuang Engineering Materials (Hubei) Co., Ltd |
-
- 4-Chlorophenyl isocyanate
104-12-1
- $10.00
- 99.%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 4-Chlorophenyl isocyanate
104-12-1
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4-Chlorophenyl isocyanate
104-12-1
- $10.00
- 99.6%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
