4-Chlorophenyl isocyanate synthesis
- Product Name:4-Chlorophenyl isocyanate
- CAS Number:104-12-1
- Molecular formula:C7H4ClNO
- Molecular Weight:153.57
32315-10-9
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104-12-1
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Yield:104-12-1 92%
Reaction Conditions:
in ethyl acetate at 0 - 5; for 3 h;Cooling with ice;Reflux;Solvent;
Steps:
5-8 Example 8
In an ice bath, add triphosgene (97.9g, 0.33mol) and 500 ml of ethyl acetate to a three-necked flask, and maintain the temperature of 0 to 5 ° C, and place all kinds of substituted anilines I, 4-chloroaniline (127.6g, 1mol ) Add slowly to the above reaction system through the dropping funnel. After the addition, the reaction was refluxed for 3 hours. The reaction was monitored by TLC. The molar ratio of triphosgene to 4-chloroaniline was 1: 3. After the reaction is completed, the filtrate is filtered, and the solvent is distilled off under reduced pressure. The residue is continuously distilled under reduced pressure to obtain the target compound substituted phenyl isocyanate II-light yellow liquid 4-chlorobenzene isocyanate.130.2g(92% yield).
References:
Suzhou Hande Chuanghong Biochemical Technology Co., Ltd.;Mao Zhongping;Ma Dongxu;Jiang Xiangsheng CN110437109, 2019, A Location in patent:Paragraph 0016; 0017; 0018; 0019
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