Trimethyl phosphonoacetate
- CAS No.
- 5927-18-4
- Chemical Name:
- Trimethyl phosphonoacetate
- Synonyms
- TMPA;METHYL DIMETHYLPHOSPHONOACETATE;Methyl (dimethoxyphosphoryl)acetate;NSC 84262;TriMethyl phosphonoacetat;TRIMETHYL PHOPHONOACETATE;trimethylacetyl phosphate;Trimethylphosphoroacetate;TRIMETHYL PHOSPHONACETATE;RIMETHYL PHOSPHONOACETATE
- CBNumber:
- CB6726270
- Molecular Formula:
- C5H11O5P
- Molecular Weight:
- 182.11
- MDL Number:
- MFCD00008452
- MOL File:
- 5927-18-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Trimethyl phosphonoacetate 98% | T79758 | 25g | $112 |
| Trimethyl phosphonoacetate 98% | T79758 | 100g | $137 |
| Trimethyl Phosphonoacetate >96.0%(GC) | P1265 | 25g | $49 |
| Trimethyl Phosphonoacetate >96.0%(GC) | P1265 | 250g | $231 |
| Trimethyl Phosphonoacetate | TRC-T798125-10G | 10g | $212 |
| More product size | |||
| Melting point | 242 °C |
|---|---|
| Boiling point | 118 °C0.85 mm Hg(lit.) |
| Density | 1.125 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Liquid |
| Specific Gravity | approximate 1.265ｇ/ml (20℃) |
| color | Clear colorless to light yellow |
| Water Solubility | Slightly miscible with water. |
| BRN | 1865177 |
| InChI | 1S/C5H11O5P/c1-8-5(6)4-11(7,9-2)10-3/h4H2,1-3H3 |
| InChIKey | SIGOIUCRXKUEIG-UHFFFAOYSA-N |
| SMILES | COC(=O)CP(=O)(OC)OC |
| LogP | -0.680 (est) |
| CAS DataBase Reference | 5927-18-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Trimethyl phosphonoacetate(5927-18-4) |
| EPA Substance Registry System | Acetic acid, (dimethoxyphosphinyl)-, methyl ester (5927-18-4) |
| UNSPSC Code | 12352108 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227-H315-H319-H335 | |||||||||
| Precautionary statements | P210e-P261-P280a-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Safety Statements | 23-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 9 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29310095 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Trimethyl phosphonoacetate price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T79758 | Trimethyl phosphonoacetate 98% | 5927-18-4 | 25g | $112 | 2026-04-30 | Buy |
| Sigma-Aldrich | T79758 | Trimethyl phosphonoacetate 98% | 5927-18-4 | 100g | $137 | 2026-04-30 | Buy |
| TCI Chemical | P1265 | Trimethyl Phosphonoacetate >96.0%(GC) | 5927-18-4 | 25g | $49 | 2026-04-30 | Buy |
| TCI Chemical | P1265 | Trimethyl Phosphonoacetate >96.0%(GC) | 5927-18-4 | 250g | $231 | 2026-04-30 | Buy |
| TRC | TRC-T798125-10G | Trimethyl Phosphonoacetate | 5927-18-4 | 10g | $212 | 2026-06-03 | Buy |
Trimethyl phosphonoacetate Chemical Properties,Uses,Production
Chemical Properties
clear colorless to light yellow liquid
Uses
Trimethyl phosphonoacetate is used in the preparation of sarin A by intramolecular Mannich-type reactions. It is involved in the Horner-Wadsworth-Emmons olefination with aldehydes and ketones to give acrylic esters. It is also involved in oxa-Michael reactions, prenylation of oxindoles and heterocyclization reactions.
Application
Trimethyl phosphonoacetate is an important Wittig-horner reagent, which can be used to manufacture important intermediates of natural compounds such as vitamins, drugs, insect pheromones, etc.
Reactant involved in:
Intramolecular Mannich-type reactions to produce the sarain A diazatricyclic core
Organocatalytic oxa-Michael reactions
Prenylation and geranylation of oxindoles
Intramolecular Horner-Wadsworth-Emmons reactions
Olefin cross-metathesis / heterocyclization
Definition
ChEBI: Trimethyl phosphonoacetate is a phosphonic ester.
reaction suitability
reaction type: C-C Bond Formation
Synthesis
The trimethyl phosphonoacetate is prepared from trimethyl phosphite and methyl chloroacetate through Michael Arbuzov rearrangement reaction. The synthetic method satisfies the chemical equations that CH2ClCOOH + CH3OH → CH5ClO2 + H2O, CH5ClO2 + C3H9O3P → C5H11O5P + CH3Cl.
Trimethyl phosphonoacetate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangxi Sunway Chemical Co., Ltd. | +86-0794-5259909 +undefined18605760166 | dave@jxswchem.com | China | 22 | 58 |
| Jiangxi Sunway Chemical Co., Ltd. | +86-0794-5259909 +undefined18605760166 | dave@jxswchem.com | China | 22 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 | sales1@chuanghaibio.com | China | 5218 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-17732866630 | mina@chuanghaibio.com | China | 18126 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Hefei Lbao Physical & Chemical Science Co.,Ltd | lbaochemicals@gmail.com | China | 670 | 58 | |
| Hangzhou Verychem Science And Technology Co.Ltd | +86-86-57188162785 13606544505 | lucy@verychem.com | China | 1212 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
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View Lastest Price from Trimethyl phosphonoacetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-28 | Trimethyl phosphonoacetate
5927-18-4
|
$10.00 | 1KG | 99.% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-05-18 | Trimethyl phosphonoacetate
5927-18-4
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd | |||
 |
2026-04-27 | Trimethyl phosphonoacetate
5927-18-4
|
1kg | 98% | 100tons | Shandong Vital Biotechnology Co., Ltd. |
-
- Trimethyl phosphonoacetate
5927-18-4
- $10.00
- 99.%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- Trimethyl phosphonoacetate
5927-18-4
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- Trimethyl phosphonoacetate
5927-18-4
- 98%
- Shandong Vital Biotechnology Co., Ltd.
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