1-(2,6-Difluorophenyl)ethan-1-one
- CAS No.
- 13670-99-0
- Chemical Name:
- 1-(2,6-Difluorophenyl)ethan-1-one
- Synonyms
- TIMTEC-BB SBB006686;2,6-DIFLUOROACETOPHENONE;2',6'-difluoroacetophenone;2',6'-Difluoroacetophenone>2',6'-Difluoroacetophenone98%;Acetophenone, 2',6'-difluoro-;1-(2,6-Difluorophenyl)ethanone;2',6'-Difluoroacetophenone 98%;Benzamide,4-(1,4-dimethylethyl)-;1-(2,6-difluorophenyl)ethan-1-one
- CBNumber:
- CB7119307
- Molecular Formula:
- C8H6F2O
- Molecular Weight:
- 156.13
- MDL Number:
- MFCD00000328
- MOL File:
- 13670-99-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2′,6′-Difluoroacetophenone 97% | 232890 | 1g | $27.6 |
| 2′,6′-Difluoroacetophenone 97% | 232890 | 5g | $55.6 |
| 2',6'-Difluoroacetophenone >98.0%(GC) | D3559 | 5g | $71 |
| 2',6'-Difluoroacetophenone >98.0%(GC) | D3559 | 25g | $286 |
| 2',6'-Difluoroacetophenone 97% | PC2577 | 5g | $21 |
| More product size | |||
| Melting point | 52-55°C |
|---|---|
| Boiling point | 76-79 °C15 mm Hg(lit.) |
| Density | 1.197 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 170 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Liquid |
| Specific Gravity | 1.197 |
| color | Clear colorless to slightly yellow |
| Water Solubility | Slightly soluble in water. |
| BRN | 2046068 |
| InChI | InChI=1S/C8H6F2O/c1-5(11)8-6(9)3-2-4-7(8)10/h2-4H,1H3 |
| InChIKey | VGIIILXIQLXVLC-UHFFFAOYSA-N |
| SMILES | C1C(F)=C(C(=O)C)C(F)=CC=1 |
| CAS DataBase Reference | 13670-99-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanone, 1-(2,6-difluorophenyl)-(13670-99-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29147000 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
1-(2,6-Difluorophenyl)ethan-1-one price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 232890 | 2′,6′-Difluoroacetophenone 97% | 13670-99-0 | 1g | $27.6 | 2023-06-20 | Buy |
| Sigma-Aldrich | 232890 | 2′,6′-Difluoroacetophenone 97% | 13670-99-0 | 5g | $55.6 | 2023-06-20 | Buy |
| TCI Chemical | D3559 | 2',6'-Difluoroacetophenone >98.0%(GC) | 13670-99-0 | 5g | $71 | 2026-04-30 | Buy |
| TCI Chemical | D3559 | 2',6'-Difluoroacetophenone >98.0%(GC) | 13670-99-0 | 25g | $286 | 2026-04-30 | Buy |
| Apolloscientific | PC2577 | 2',6'-Difluoroacetophenone 97% | 13670-99-0 | 5g | $21 | 2026-06-04 | Buy |
1-(2,6-Difluorophenyl)ethan-1-one Chemical Properties,Uses,Production
Chemical Properties
Clear colourless to light yellow liquid
Uses
2,6-Difluoroacetophenone was used in the synthesis of 2-amino-4-alkyl- and 2-amino-4-arylquinazolines.
General Description
2′,6′-Difluoroacetophenone undergoes ruthenium-catalyzed phenylation with phenylboronate via carbon-fluorine bond cleavage to yield 2′,6′-diphenylacetophenone.
Synthesis
18063-02-0
105-53-3
13670-99-0
GENERAL STEPS: Magnesium chloride (1.65 g, 17.3 mmol) was added to a solution of diethyl malonate (1.24 g, 7.7 mmol) in ethyl acetate (20 mL) and the mixture was stirred at room temperature for 30 minutes. Subsequently, triethylamine (2.35 mL, 16.7 mmol) was added and stirring was continued for 30 minutes. The reaction mixture was cooled to 0 °C and a solution of ethyl acetate (5 mL) of 2,6-difluorobenzoyl chloride (1.0 g, 5.6 mmol) was slowly added dropwise over a period of 15 min, ensuring that the internal temperature did not exceed 5 °C. After dropwise addition, the reaction mixture was returned to room temperature and stirred for 3 hours. Upon completion of the reaction, the reaction was quenched with 1N hydrochloric acid (50 mL) and extracted with ethyl acetate (100 mL). The organic phase was separated, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to give the intermediate (1.97 g) as a colorless oil. The oil was dissolved in acetonitrile (25 mL), water (2 mL) was added, and the solution was transferred to a pressure reactor and sealed. The mixture was heated to 150 °C and kept for 1 hour. At the end of the reaction, it was cooled to room temperature and the pressure was released. The yield of 2,6-difluoroacetophenone was determined to be 874 mg (100% yield) by HPLC weight analysis.
References
[1] Patent: WO2013/85686, 2013, A1. Location in patent: Page/Page column 22
1-(2,6-Difluorophenyl)ethan-1-one Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 9976 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
View Lastest Price from 1-(2,6-Difluorophenyl)ethan-1-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 1-(2,6-Difluorophenyl)ethan-1-one
13670-99-0
|
$10.00 | 1KG | 99% | 5tons | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2024-04-28 | 1-(2,6-Difluorophenyl)ethanone
13670-99-0
|
$5.00 | 1kg | 99.92% | 50000tons | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2022-01-27 | 2',6'-Difluoroacetophenone
13670-99-0
|
1KG | 98.2% | 100 tons | Honest Joy Holdings Limited
|
-
- 1-(2,6-Difluorophenyl)ethan-1-one
13670-99-0
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 1-(2,6-Difluorophenyl)ethanone
13670-99-0
- $5.00
- 99.92%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- 2',6'-Difluoroacetophenone
13670-99-0
- $0.00
- 98.2%
- Honest Joy Holdings Limited
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