ChemicalBook >> CAS DataBase List >>1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide

1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide

1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide structure

CAS No.: 2648418-86-2

Chemical Name:: 1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide

Synonyms: DGKα-IN-3;3-Quinolinecarboxamide, 1,2-dihydro-1-methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]dec-8-yl]-;1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide

CBNumber:: CB714213224

Molecular Formula:: C26H27F3N4O3

Molecular Weight:: 500.51

MDL Number:

MOL File:: 2648418-86-2.mol

TDS File:: TDS

Last updated:2026-04-21 10:31:43

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1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide Properties

Boiling point	634.854±55.00 °C(Press: 760.00 Torr)(predicted)
Density	1.423±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	14.711±0.20(predicted)

1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide Chemical Properties,Uses,Production

Uses

DGKα-IN-3 (example 25) is a DGKα inhibitor with the IC50 of 283 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study.

References

[1] Schmees, Norbert, et al. Preparation of substituted aminoquinolones as DGKα inhibitors for immune activation. WO2021105115.

1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	19956	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29867	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58

View Lastest Price from 1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-20	DGKα-IN-3 2648418-86-2				10g	TargetMol Chemicals Inc.

DGKα-IN-3
2648418-86-2
TargetMol Chemicals Inc.

1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide DGKα-IN-3 3-Quinolinecarboxamide, 1,2-dihydro-1-methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]dec-8-yl]- 2648418-86-2

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