2-AMINO-5-(4-METHOXYPHENYL)-1,3,4-THIADIAZOLE
- CAS No.
- 1014-25-1
- Chemical Name:
- 2-AMINO-5-(4-METHOXYPHENYL)-1,3,4-THIADIAZOLE
- Synonyms
- AKOS B014673;BUTTPARK 24\04-30;ART-CHEM-BB B014673;IFLAB-BB F1386-0072;TIMTEC-BB SBB000467;2-AMINO-5-(METHOXYPHENYL)-1,3,4-THIADIA&;5-(4-Methoxyphenyl)-1,3,4-thiadazol-2-amine;5-(4-METHOXYPHENYL)-1,3,4-THIADIAZOL-2-AMINE;2-AMINO-5-(4-METHOXYPHENYL)-1,3,4-THIADIAZOLE;1,3,4-Thiadiazol-2-aMine, 5-(4-Methoxyphenyl)-
- CBNumber:
- CB7160349
- Molecular Formula:
- C9H9N3OS
- Molecular Weight:
- 207.25
- MDL Number:
- MFCD00813220
- MOL File:
- 1014-25-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Amino-5-(4-methoxyphenyl)-1,3,4-thiadiazole 97% | 576026 | 1g | $23 |
| 5-(4-Methoxyphenyl)-1,3,4-thiadiazol-2-amine | M3799 | 1G | $35 |
| 5-(4-Methoxyphenyl)-1,3,4-thiadiazol-2-amine | M3799 | 5G | $125 |
| 2-Amino-5-(4-methoxyphenyl)-1,3,4-thiadiazole | 415193 | 100mg | $305 |
| 2-Amino-5-(4-methoxyphenyl)-1,3,4-thiadiazole | 415193 | 250mg | $382 |
| Melting point | 185-187 °C |
|---|---|
| Boiling point | 393.1±44.0 °C(Predicted) |
| Density | 1.320±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | solid |
| pka | 3.37±0.10(Predicted) |
| Appearance | White to light yellow Solid |
| InChI | 1S/C9H9N3OS/c1-13-7-4-2-6(3-5-7)8-11-12-9(10)14-8/h2-5H,1H3,(H2,10,12) |
| InChIKey | UJBCFMCQLVRXBQ-UHFFFAOYSA-N |
| SMILES | COc1ccc(cc1)-c2nnc(N)s2 |
| CAS DataBase Reference | 1014-25-1(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
2-AMINO-5-(4-METHOXYPHENYL)-1,3,4-THIADIAZOLE price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 576026 | 2-Amino-5-(4-methoxyphenyl)-1,3,4-thiadiazole 97% | 1014-25-1 | 1g | $23 | 2023-06-20 | Buy |
| TCI Chemical | M3799 | 5-(4-Methoxyphenyl)-1,3,4-thiadiazol-2-amine | 1014-25-1 | 1G | $35 | 2026-04-30 | Buy |
| TCI Chemical | M3799 | 5-(4-Methoxyphenyl)-1,3,4-thiadiazol-2-amine | 1014-25-1 | 5G | $125 | 2026-04-30 | Buy |
| Usbiological | 415193 | 2-Amino-5-(4-methoxyphenyl)-1,3,4-thiadiazole | 1014-25-1 | 100mg | $305 | 2026-06-03 | Buy |
| Usbiological | 415193 | 2-Amino-5-(4-methoxyphenyl)-1,3,4-thiadiazole | 1014-25-1 | 250mg | $382 | 2026-06-03 | Buy |
2-AMINO-5-(4-METHOXYPHENYL)-1,3,4-THIADIAZOLE Chemical Properties,Uses,Production
Uses
2-Amino-5-(4-methoxyphenyl)-1,3,4-thiadiazole is a thiadiazole derivative that is potent and selective human adenosine A3 receptor antagonist. It is also used as a reactant in the synthesis of substituted thiadiazolyl(styryl)quinazolinones with anticonvulsant, sedative-hypnotic, and CNS depressant activities.
Synthesis Reference(s)
Journal of the American Chemical Society, 73, p. 906, 1951 DOI: 10.1021/ja01147a007
Synthesis
79-19-6
100-09-4
1014-25-1
5.1.1 Synthesis of 5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-amine (61): p-Methoxybenzoic acid (5.18 g, 25 mmol) and aminothiourea (2.28 g, 25 mmol) were dissolved in POCl3 (7 mL) and stirred vigorously for 0.5 hours at 75°C. After the reaction was completed, H2O (30 mL) was added and the reaction mixture was heated to reflux for 4 hours. Subsequently, the pH of the reaction mixture was adjusted with 50% NaOH solution to 8. The precipitate was collected by filtration and the filter cake was recrystallized with ethanol to afford yellow crystals of the target compound 61 in 82% yield with a melting point of 219-220 °C (EtOH).ESI-MS m/z: 208.2 [M + H]+; 1H NMR (DMSO-d6) δ 3.80 (s, 3H ), 7.01-7.03 (m, 2H), 7.23 (s, 2H), 7.67-7.69 (m, 2H). Compounds 60-81 were synthesized in the same way.
References
[1] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 14, p. 6663 - 6668
[2] Tetrahedron, 2018, vol. 74, # 31, p. 4161 - 4167
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 21, p. 5766 - 5775
[4] Medicinal Chemistry, 2014, vol. 10, # 4, p. 376 - 381
[5] Medicinal Chemistry Research, 2012, vol. 21, # 6, p. 816 - 824
2-AMINO-5-(4-METHOXYPHENYL)-1,3,4-THIADIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
2-AMINO-5-(4-METHOXYPHENYL)-1,3,4-THIADIAZOLE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-15225627621 +86-13213167925 | jiuyitime@fdachem.com | China | 16511 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9996 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Suzhou Victorypharm Co.,Ltd. | +86-13916956214 | sales@victory-pharm.com | China | 1299 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49895 | 58 |
View Lastest Price from 2-AMINO-5-(4-METHOXYPHENYL)-1,3,4-THIADIAZOLE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-02 | 2-Amino-5-(4-methoxyphenyl)-1,3,4-thiadiazole
1014-25-1
|
$1.10-9.90 | 1kg | 99%min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD |
-
- 2-Amino-5-(4-methoxyphenyl)-1,3,4-thiadiazole
1014-25-1
- $1.10-9.90
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
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