18alpha-Glycyrrhetinic acid
- CAS No.
- 1449-05-4
- Chemical Name:
- 18alpha-Glycyrrhetinic acid
- Synonyms
- Nsc 35350;Triterpene;Ccris 3963;Brn 2956366;Einecs 215-907-9;18α-Glycyrrhetinic;Enoxolone impurity A;18a-Glycyrrhetic acid;18α-Glycyrrhetic acid;18A-GLYCYRRHETINIC ACID
- CBNumber:
- CB7172205
- Molecular Formula:
- C30H46O4
- Molecular Weight:
- 470.68
- MDL Number:
- MFCD00064897
- MOL File:
- 1449-05-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 18α-Glycyrrhetinic acid ≥95% | G8503 | 250mg | $126 |
| 18α-Glycyrrhetinic acid ≥95% | G8503 | 1g | $466 |
| 18Alpha-Glycyrrhetinic Acid | TRC-G735005-500MG | 500mg | $892 |
| 18Alpha-Glycyrrhetinic Acid | TRC-G735005-1G | 1g | $1515 |
| 18Alpha-Glycyrrhetinic Acid | TRC-G735005-100MG | 100mg | $199 |
| More product size | |||
| Melting point | 331-333°C |
|---|---|
| Boiling point | 492.11°C (rough estimate) |
| Density | 0.9967 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.71±0.70(Predicted) |
| color | White to Off-White |
| InChIKey | MPDGHEJMBKOTSU-PMTKVOBESA-N |
| SMILES | [H][C@]12C[C@](C)(CC[C@]1(C)CC[C@]3(C)C2=CC(=O)C4[C@@]5(C)CC[C@H](O)C(C)(C)[C@]5([H])CC[C@@]34C)C(O)=O |
| LogP | 6.570 (est) |
| CAS DataBase Reference | 1449-05-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | X6NYL2CP2E |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | ection |
| WGK Germany | 3 |
| RTECS | RK0190000 |
| HS Code | 29189900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
18alpha-Glycyrrhetinic acid price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G8503 | 18α-Glycyrrhetinic acid ≥95% | 1449-05-4 | 250mg | $126 | 2026-04-30 | Buy |
| Sigma-Aldrich | G8503 | 18α-Glycyrrhetinic acid ≥95% | 1449-05-4 | 1g | $466 | 2026-04-30 | Buy |
| TRC | TRC-G735005-500MG | 18Alpha-Glycyrrhetinic Acid | 1449-05-4 | 500mg | $892 | 2026-06-03 | Buy |
| TRC | TRC-G735005-1G | 18Alpha-Glycyrrhetinic Acid | 1449-05-4 | 1g | $1515 | 2026-06-03 | Buy |
| TRC | TRC-G735005-100MG | 18Alpha-Glycyrrhetinic Acid | 1449-05-4 | 100mg | $199 | 2026-06-03 | Buy |
18alpha-Glycyrrhetinic acid Chemical Properties,Uses,Production
Chemical Properties
Glycyrrhetinic acid is a kind of glycoside composed of glycyrrhizic acid-ff two molecules glucuronic acid. It appears as white crystalline powder with sweet taste. The sweetness is about 200 times of the sucrose. Its sweetness is different from other sweeteners such as sucrose. After eating, you can sense the sweetness only after a few moments but the retention time is long. Combination of a small amount of glycyrrhizin and sucrose can save 20% sucrose without affecting the sweetness. Although having no aroma, it has incense effect. It has a melting point (decomposition) of 220 ° C. The aqueous solution is weakly acidic and can be treated by acid.
Uses
Sweeteners; sweetness improving agents; flavor enhancers (dairy products, cocoa products, egg products, mutton), flavoring agents (function well especially when used in combination with salt), Chinese folk mostly use it in sauce and sauce products, pickled goods and so on.
Uses
18α-Glycyrrhetinic acid may be used to synthesize:
- 3-keto-18α-glycyrrhetinic acid
- methyl esters of 18α-glycyrrhetinic acid
- methyl esters of 3-keto-18α-glycyrrhetinic acid
General Description
18α-Glycyrrhetinic acid (18α-GA) is a bioactive triterpenoid found in licorice. It shows selective inhibition of 11-HSD1 (11-hydroxysteroid dehydrogenase 1). It also shows anti-proliferative and apoptotic effect on hepatic stellate cells (HSCs).
in vivo
18α-Glycyrrhetinic acid (18α-GA) treatment significantly enhances life span of C. elegans strains with the most effective concentration being 20μg/mL. Results reveal a significant delay of paralysis upon 18α-Glycyrrhetinic acid treatment. 18α-Glycyrrhetinic acid treatment also confers a significant reduction of Aβ deposits[2].
IC 50
Proteasome; NF-κB
18alpha-Glycyrrhetinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +86-18080483897 | sales@biopurify.com | China | 4616 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | 029-84385017; +8613259417953 | sales@pioneerbiotech.com | China | 1287 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
View Lastest Price from 18alpha-Glycyrrhetinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-02 | 18α-Glycyrrhetinic acid
1449-05-4
|
$42.00-66.00 | 99.68% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-02-14 | Glycyrrhetinic acid 1449-05-4
1449-05-4
|
$7.50 | 20mg | ≥98% | 1000.00 kgs | NanJing Spring & Autumn Biological Engineering CO., LTD. | |
 |
2021-07-13 | 18alpha-Glycyrrhetinic acid
1449-05-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 18α-Glycyrrhetinic acid
1449-05-4
- $42.00-66.00
- 99.68%
- TargetMol Chemicals Inc.
-
- Glycyrrhetinic acid 1449-05-4
1449-05-4
- $7.50
- ≥98%
- NanJing Spring & Autumn Biological Engineering CO., LTD.
-
- 18alpha-Glycyrrhetinic acid
1449-05-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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