2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE
![2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE Structure](CAS/GIF/112342-72-0.gif)
- CAS No.
- 112342-72-0
- Chemical Name:
- 2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE
- Synonyms
- 2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE;Thiazolo[4,5-b]pyrazin-2-amine, 6-bromo-
- CBNumber:
- CB72452796
- Molecular Formula:
- C5H3BrN4S
- Molecular Weight:
- 231.07
- MDL Number:
- MFCD09909710
- MOL File:
- 112342-72-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Amino-6-bromothiazolo[4,5-b]pyrazine | 415329 | 1g | $623 |
| 2-Amino-6-bromothiazolo[4,5-b]pyrazine | 415329 | 5g | $1770 |
| 2-Amino-6-bromothiazolo[4,5-b]pyrazine | 072350 | 1.00g | $130 |
| 2-Amino-6-bromothiazolo[4,5-b]pyrazine | 072350 | 5.00g | $651 |
| 2-Amino-6-bromothiazolo[4,5-b]pyrazine | 072350 | 25.00g | $3106 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 415329 | 2-Amino-6-bromothiazolo[4,5-b]pyrazine | 112342-72-0 | 1g | $623 | 2026-06-03 | Buy |
| Usbiological | 415329 | 2-Amino-6-bromothiazolo[4,5-b]pyrazine | 112342-72-0 | 5g | $1770 | 2026-06-03 | Buy |
| Matrix Scientific | 072350 | 2-Amino-6-bromothiazolo[4,5-b]pyrazine | 112342-72-0 | 1.00g | $130 | 2026-05-18 | Buy |
| Matrix Scientific | 072350 | 2-Amino-6-bromothiazolo[4,5-b]pyrazine | 112342-72-0 | 5.00g | $651 | 2026-05-18 | Buy |
| Matrix Scientific | 072350 | 2-Amino-6-bromothiazolo[4,5-b]pyrazine | 112342-72-0 | 25.00g | $3106 | 2026-05-18 | Buy |
2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE Chemical Properties,Uses,Production
Uses
2-Amino-6-bromothiazolo[4,5-b]pyrazine is derived from 2-Amino-3,5-dibromopyrazine (A604635), which is used in the preparation of conjugated polymers for neurotoxin detection and is an intermediate in the preparation of rho kinase (ROCK) inhibitors.
Synthesis
![Ethyl (6-broMothiazolo[4,5-b]pyrazin-2-yl)carbaMate](/CAS/GIF/112342-70-8.gif)
112342-70-8
![2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE](/CAS/GIF/112342-72-0.gif)
112342-72-0
General procedure for the synthesis of 6-bromothiazolo[4,5-b]pyrazin-2-amine from ethyl (6-bromothiazolo[4,5-b]pyrazin-2-yl)carbamate: 2 N aqueous sodium hydroxide (7.91) was added to a methanolic (8 mL) suspension of ethyl (6-bromothiazolo[4,5-b]pyrazin-2-yl)carbamate (480 mg, 1.58 mmol). mL, 15.83 mmol). The mixture was heated under reflux conditions for 5 hours. Upon completion of the reaction, the mixture was acidified with 2 N HCl to pH < 7. Subsequently, the reaction mixture was neutralized with saturated sodium bicarbonate solution and extracted with ethyl acetate (3 × 10 mL). The organic layers were combined, washed sequentially with saturated sodium bicarbonate solution and saturated aqueous sodium chloride solution, and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give the crude product. The precipitate was collected by filtration to afford 6-bromothiazolo[4,5-b]pyrazin-2-amine (334 mg, 91.0% yield) as a pale yellow solid.1H-NMR (DMSO-d6) δ: 8.37 (s, 1H), 8.59 (brs, 2H).
References
[1] Patent: EP2351744, 2011, A1. Location in patent: Page/Page column 74
[2] Heterocycles, 1987, vol. 26, # 3, p. 689 - 697
2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49895 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 |
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