ChemicalBook >> CAS DataBase List >>7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
- CAS No.
- 148870-57-9
- Chemical Name:
- 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
- Synonyms
- 1,3-Dihydro-3-(3-iodopropyl)-7,8-dimethoxy-2H-3-benzazepin-2-one;Ivabradine int;Ivabradine Impurity g;7,8-Dimethoxy-3-(3-iodopropyl);7,8-DiMethoxy-3-(3-iodopropyl)-1,3-dihydro-2H;3-(3-Iodopropyl)-7,8-dimethoxy-1H-3-benzazepin-2-one;3-(3-iodopropyl)-7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one;3-(3-IODOPROPYL)-7,8-DIMETHOXY-1,3-DIHYDRO-2H-3-BENZAPINE-2-ONE;7,8-DiMethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-on;3-(3-iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2...
- CBNumber:
- CB72500145
- Molecular Formula:
- C15H18INO3
- Molecular Weight:
- 387.21
- MDL Number:
- MFCD09955403
- MOL File:
- 148870-57-9.mol
- MSDS File:
- SDS
Last updated:2026-05-28 03:22:20
| Product description | Number | Pack Size | Price |
| 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one | 091119 | 250.00mg | $265 |
| 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one | 091119 | 1.00g | $588 |
| 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one 95+% | D58323 | 250mg | $20 |
| 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one 95+% | D58323 | 1g | $25 |
| 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one 95+% | D58323 | 5g | $30 |
| More product size | |||
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 091119 | 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one | 148870-57-9 | 250.00mg | $265 | 2026-05-18 | Buy |
| Matrix Scientific | 091119 | 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one | 148870-57-9 | 1.00g | $588 | 2026-05-18 | Buy |
| Synthonix | D58323 | 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one 95+% | 148870-57-9 | 250mg | $20 | 2026-05-06 | Buy |
| Synthonix | D58323 | 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one 95+% | 148870-57-9 | 1g | $25 | 2026-05-06 | Buy |
| Synthonix | D58323 | 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one 95+% | 148870-57-9 | 5g | $30 | 2026-05-06 | Buy |
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one Chemical Properties,Uses,Production
Synthesis
![(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one](/CAS/GIF/85175-59-3.gif)
85175-59-3
148870-57-9
A mixed solution of 7,8-dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-one (50.00 g, 169 mmol) with sodium iodide (32.75 g, 218 mmol) in methyl isobutyl ketone (375 mL) was reacted under argon protection at 117-118 °C with stirring. The reaction process was monitored by high performance liquid chromatography (HPLC). Upon completion of the reaction, the mixture was concentrated under reduced pressure and the residue was diluted with dichloromethane (375 mL) and water (190 mL). The organic phase was separated, washed with water (190 mL) and concentrated again under reduced pressure. The resulting residue was treated with methyl tert-butyl ether (190 mL) and the resulting suspension was cooled to 0 °C. After continuous stirring at 0 °C for 1 h, the solid product was collected by filtration, washed with methyl isobutyl ether (40 mL) and dried at 23 °C/100 mbar for 2 h. The final product was obtained as 60.10 g of light yellow solid product in 92% yield.
References
[1] Patent: WO2014/114341, 2014, A1. Location in patent: Page/Page column 15; 16
[2] Patent: WO2014/102827, 2014, A1. Location in patent: Paragraph 0121
[3] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 17, p. 2351 - 2354
[4] Patent: WO2010/72409, 2010, A1. Location in patent: Page/Page column 19-20
[5] Patent: WO2014/20534, 2014, A1. Location in patent: Page/Page column 13
Synthesis of 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one from (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 149)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +86-15064153060 | sales01@jndxj.com | China | 288 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
View Lastest Price from 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-20 | 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
148870-57-9
|
1kg | 0.99 | 100kg | Hebei Yanxi Chemical Co., Ltd. | ||
 |
2024-01-08 | 7, 8-Dimethoxy-3- (3-iodopropyl) -1, 3-Dihydro-2h-3-Benzazepin-2-One
148870-57-9
|
$15.00-30.00 | 1kg | 99.50% | 20tons | Wuhan Boyuan Import & Export Co., LTD | |
 |
2024-01-08 | 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
148870-57-9
|
$50.00-80.00 | 1kg | 99.99% | 3 tons per week | Wuhan Boyuan Import & Export Co., LTD |
-
- 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
148870-57-9
- $0.00
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- 7, 8-Dimethoxy-3- (3-iodopropyl) -1, 3-Dihydro-2h-3-Benzazepin-2-One
148870-57-9
- $15.00-30.00
- 99.50%
- Wuhan Boyuan Import & Export Co., LTD
-
- 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
148870-57-9
- $50.00-80.00
- 99.99%
- Wuhan Boyuan Import & Export Co., LTD
148870-57-9(7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one)Related Search:
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3-(3-Iodopropyl)-7,8-diMethoxy-1,3-dihydro-2H-3-benzazepin-2-one
7,8-DiMethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-on
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7,8-DiMethoxy-3-(3-iodopropyl)-1,3-dihydro-2H
3-(3-iodopropyl)-7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one
Ivabradine Impurity g
Ivabradine int
2H-3-Benzazepin-2-one,1,3-dihydro-3-(3-iodopropyl)-7,8-dimethoxy-
3-(3-IODOPROPYL)-7,8-DIMETHOXY-1,3-DIHYDRO-2H-3-BENZAPINE-2-ONE
7,8-dimethoxy-3- (3-iodopropyl) - 1,3-dihydro-2h-3-benzoazepine-2-one
3-(3-iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2...
3-(3-Iodopropyl)-7,8-dimethoxy-1H-3-benzazepin-2-one
7,8-Dimethoxy-3 (3-iodopropyl) -1,3-dihydro-2H-3-benzoazo-2-one
Ivabradine Iodo Impurity
6-3-(3-iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H- benzo[d]azepin-2-one
1,3-Dihydro-3-(3-iodopropyl)-7,8-dimethoxy-2H-3-benzazepin-2-one
148870-57-9
XHL
