ACEA
- CAS No.
- 220556-69-4
- Chemical Name:
- ACEA
- Synonyms
- ACEA;2'-CHLORO-AEA;ACEA (ethanol solution);Terfenadine Impurity 23;ARACHIDONYL-2-CHLOROETHYLAMIDE;ARACHIDONYL-2'-CHLOROETHYLAMIDE;Arachidonoyl 2'-Chloroethylamide;ACEA, 5mg/ml solution in ethanol;Eicosapentaenoic Acid Impurity 51;ARACHIDONYL-2'-CHLOROETHYLAMIDE HYDRATE
- CBNumber:
- CB7484072
- Molecular Formula:
- C22H36ClNO
- Molecular Weight:
- 365.98
- MDL Number:
- MFCD02683581
- MOL File:
- 220556-69-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Arachidonyl-2′-chloroethylamide hydrate ≥97% (HPLC), oil | A9719 | 25mg | $438 |
| Arachidonoyl 2''-Chloroethylamide ≥95% | 91054 | 5mg | $44 |
| Arachidonoyl 2''-Chloroethylamide ≥95% | 91054 | 10mg | $80 |
| Arachidonoyl 2''-Chloroethylamide ≥95% | 91054 | 25mg | $183 |
| Arachidonoyl 2''-Chloroethylamide ≥95% | 91054 | 50mg | $322 |
| More product size | |||
ACEA price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A9719 | Arachidonyl-2′-chloroethylamide hydrate ≥97% (HPLC), oil | 220556-69-4 | 25mg | $438 | 2026-04-30 | Buy |
| Cayman Chemical | 91054 | Arachidonoyl 2''-Chloroethylamide ≥95% | 220556-69-4 | 5mg | $44 | 2026-04-30 | Buy |
| Cayman Chemical | 91054 | Arachidonoyl 2''-Chloroethylamide ≥95% | 220556-69-4 | 10mg | $80 | 2026-04-30 | Buy |
| Cayman Chemical | 91054 | Arachidonoyl 2''-Chloroethylamide ≥95% | 220556-69-4 | 25mg | $183 | 2026-04-30 | Buy |
| Cayman Chemical | 91054 | Arachidonoyl 2''-Chloroethylamide ≥95% | 220556-69-4 | 50mg | $322 | 2026-04-30 | Buy |
ACEA Chemical Properties,Uses,Production
Description
Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1.4 and >2,000 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACEA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide (AEA; ), in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.
Uses
A synthetic agonist of the cannabinoid receptor 1 (CB1R). ACEA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R).
Definition
ChEBI: Arachidonyl-2'-chloroethylamide is a fatty amide obtained by the formal condensation of arachidonic acid with 2-chloroethanamine. It is a potent agonist of the CB1 receptor (Ki = 1.4 nM) and also has a low affinity for the CB2 receptor (Ki = 3100 nM). It has a role as a CB1 receptor agonist, a neuroprotective agent and a CB2 receptor agonist. It is an organochlorine compound, a secondary carboxamide, a fatty amide and a synthetic cannabinoid. It is functionally related to an arachidonic acid.
Biological Activity
Potent and highly selective CB 1 receptor agonist (K i = 1.4 nM). Displays > 1400-fold selectivity over CB 2 receptors. Active in vivo . Also available as part of the Cannabinoid CB 1 Receptor Tocriset™ .
Biochem/physiol Actions
Potent and selective neuronal CB1 cannabinoid receptor agonist.
Enzyme inhibitor
This synthetic CB1 receptor agonist and anandamide (N- arachidonylethanolamide) analogue (FW = 365.99 g/mol; CAS 220556-69-4; Symbol: ACEA) is a selective agonist of cannabinoid receptor-1 (Ki = 1.4 nM) but has low affinity to the cannabinoid receptor 2 (Ki = 3.1 μM). ACEA inhibits forskolin-induced cAMP accumulation in Chinese hamster ovary cells expressing the human CB1 receptor. It also increases the binding of [ 35 S]GTPgS to cerebellar membranes and inhibits electrically evoked contractions of the mouse vas deferens. ACEA produces hypothermia in mice, an effect that is inhibited by co-administration of the CB1 receptor antagonist SR141716A.
storage
Store at -20°C
ACEA Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32466 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9942 | 58 |
| Shaanxi Dideu New Materials Co. Ltd | 18192503167 | 1036@dideu.com | China | 12427 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Xingji Pharmaceutical (Shanghai) Co., Ltd | 15705593425 | support@utgene.com | China | 302 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
