2-Quinoxalinecarboxylic acid methyl ester
- CAS No.
- 1865-11-8
- Chemical Name:
- 2-Quinoxalinecarboxylic acid methyl ester
- Synonyms
- QCA-Methyl ester;Methyl quinoxaline-2-carboxylate;Methyl quinoxaline-2-carboxylate 98%;-Quinoxalinecarboxylic acid Methyl ester;2-Quinoxalinecarboxylic acid methyl ester
- CBNumber:
- CB82217152
- Molecular Formula:
- C10H8N2O2
- Molecular Weight:
- 188.18
- MDL Number:
- MFCD02167640
- MOL File:
- 1865-11-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Quinoxalinecarboxylic Acid Methyl Ester | TRC-Q765270-250MG | 250mg | $193 |
| 2-Quinoxalinecarboxylic Acid Methyl Ester | TRC-Q765270-2.5G | 2.5g | $1518 |
| Methyl quinoxaline-2-carboxylate 95% | OR300583 | 1g | $400 |
| Methyl quinoxaline-2-carboxylate 95% | OR300583 | 5g | $1375 |
| Quinoxaline-2-carboxylic acid methyl ester | 059244 | 250.00mg | $58 |
| More product size | |||
| Melting point | 110-110.5 °C |
|---|---|
| Boiling point | 302.8±22.0 °C(Predicted) |
| Density | 1.272±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Sparingly) |
| form | Solid |
| pka | 0.22±0.30(Predicted) |
| color | Brown to Dark Brown |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933992000 |
2-Quinoxalinecarboxylic acid methyl ester price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-Q765270-250MG | 2-Quinoxalinecarboxylic Acid Methyl Ester | 1865-11-8 | 250mg | $193 | 2026-06-03 | Buy |
| TRC | TRC-Q765270-2.5G | 2-Quinoxalinecarboxylic Acid Methyl Ester | 1865-11-8 | 2.5g | $1518 | 2026-06-03 | Buy |
| Apolloscientific | OR300583 | Methyl quinoxaline-2-carboxylate 95% | 1865-11-8 | 1g | $400 | 2026-06-04 | Buy |
| Apolloscientific | OR300583 | Methyl quinoxaline-2-carboxylate 95% | 1865-11-8 | 5g | $1375 | 2026-06-04 | Buy |
| Matrix Scientific | 059244 | Quinoxaline-2-carboxylic acid methyl ester | 1865-11-8 | 250.00mg | $58 | 2026-05-18 | Buy |
2-Quinoxalinecarboxylic acid methyl ester Chemical Properties,Uses,Production
Uses
2-Quinoxalinecarboxylic Acid Methyl Ester has been used as a reactant in the synthesis of quinoxaline derivatives that show antimycobacterial activity, while displaying minor activity itself. In addition to having the substructure that exhibits antitumor activity, it is also used in the design of guanine-guanine selective DNA cleaving agents.
Synthesis
67-56-1
879-65-2
1865-11-8
2-Quinoxaline carboxylic acid (1.0 g, 5.7 mmol, 1.0 eq.) was dissolved in 20 mL of methanol and thionyl chloride (1.25 mL, 17.2 mmol, 3.0 eq.) was added slowly. The reaction mixture was heated to reflux for 3 hours. After completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure to remove the solvent. The residue was extracted with ethyl acetate, washed with water, partitioned and the organic phase was dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure. Purification by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=5:1) afforded the light yellow solid product methyl quinoxaline-2-carboxylate (1.01 g, yield 93.5%).
References
[1] Advanced Synthesis and Catalysis, 2009, vol. 351, # 16, p. 2549 - 2552
[2] Patent: CN107383024, 2017, A. Location in patent: Paragraph 0395
[3] Patent: WO2018/116072, 2018, A1. Location in patent: Page/Page column 74
[4] Supramolecular Chemistry, 2015, vol. 27, # 11-12, p. 780 - 786
[5] Tetrahedron, 2016, vol. 72, # 10, p. 1375 - 1380
2-Quinoxalinecarboxylic acid methyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| BeiJing Hwrk Chemicals Limted | 0757-86329057 18934348241 | sales4.gd@hwrkchemical.com | China | 14063 | 55 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42934 | 64 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10266 | 58 |
| Shanghai Litong Chemical Technology Co.,Ltd. | 13598610367 0373-7129549 | 2468833170@qq.com | China | 932 | 58 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 4742 | 55 |
| Bide Pharmatech Ltd. | 400-400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
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