6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
![6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one Structure](CAS2/GIF/35570-68-4.gif)
- CAS No.
- 35570-68-4
- Chemical Name:
- 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
- Synonyms
- 6-Chlorooxazolo[4,5-b]pyridin-2(3H);6-Chloro-3H-oxazolo[4,5-b]pyridin-2-one;6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one;6-chlorooxazole[4,5-b]pyridine-2(3H)-one;Oxazolo[4,5-b]pyridin-2(3H)-one, 6-chloro-;6-chloro-3H-[1,3]oxazolo[4,5-b]pyridin-2-one;6-chloro[1,3]oxazolo[4,5-b]pyridin-2(3H)-one;6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one （Crizotinib intermediate）
- CBNumber:
- CB82484862
- Molecular Formula:
- C6H3ClN2O2
- Molecular Weight:
- 170.55
- MDL Number:
- MFCD14706178
- MOL File:
- 35570-68-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one 98% | OR939132 | 1g | $21 |
| 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one 98% | OR939132 | 5g | $29 |
| 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one 98% | OR939132 | 25g | $134 |
| 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one 98% | OR939132 | 100g | $528 |
| 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one 98% | OR939132 | 500g | $2402 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
| HS Code | 2934999090 |
6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR939132 | 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one 98% | 35570-68-4 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR939132 | 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one 98% | 35570-68-4 | 5g | $29 | 2026-06-04 | Buy |
| Apolloscientific | OR939132 | 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one 98% | 35570-68-4 | 25g | $134 | 2026-06-04 | Buy |
| Apolloscientific | OR939132 | 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one 98% | 35570-68-4 | 100g | $528 | 2026-06-04 | Buy |
| Apolloscientific | OR939132 | 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one 98% | 35570-68-4 | 500g | $2402 | 2026-06-04 | Buy |
6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one Chemical Properties,Uses,Production
Synthesis
![2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one](/CAS/GIF/60832-72-6.gif)
60832-72-6
![6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one](/CAS2/GIF/35570-68-4.gif)
35570-68-4
The general procedure for the synthesis of 6-chloro-oxazolo[4,5-b]pyridin-2(3H)-one using 2,3-dihydropyrido[2,3-d][1,3]oxazol-2-one as starting material was as follows: first, DMF (9 L) was added to a 100 L autoclave, a mechanical stirrer was started, and 2,3-dihydropyrido[2,3-d][1,3]oxazol-2-one ( 10 kg) and stirred until completely dissolved. Subsequently, N-chlorosuccinimide (12.16 kg) was dissolved in DMF (30 L) and slowly added dropwise to the reactor, during which the temperature of the reaction was controlled not to exceed 40 °C (cooled by a circulating condensate pump if necessary). After dropwise addition, the reaction mixture was stirred at room temperature overnight. The reaction progress was monitored by TLC and GC. Upon completion of the reaction, water (39 L) was slowly added under cooling conditions and stirring was continued for 60 minutes before filtration. The filter cake was washed twice with water and subsequently dried under vacuum to give a crude product of 11.8 kg.Finally, the crude product was recrystallized by dichloromethane and ethyl acetate to give the pure product 6-chloroxazolo[4,5-b]pyridin-2(3H)-one (11.1 kg) in 89% yield.
References
[1] Patent: CN103709175, 2016, B. Location in patent: Paragraph 0024-0025
[2] Patent: CN103755627, 2016, B. Location in patent: Paragraph 0022; 0023
[3] Patent: WO2018/37223, 2018, A1. Location in patent: Page/Page column 222
[4] Helvetica Chimica Acta, 1976, vol. 59, p. 1593 - 1612
6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Haibo Biotechnology Co., Ltd | +86-18629295024 | qinhe02@xaltbio.com | China | 997 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
| Shanghai UCHEM Inc. | +86-18930848214 +86-021-56762820 | sales@myuchem.com | China | 8886 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8618071025641 | eric@witopchemical.com | China | 23541 | 58 |
| LUYUNJIA CHEMISTRY XIAMEN LIMITED | +86-592-5360779 +86-13055435203 | China | 5988 | 58 | |
| Xiamen Eagle Chemical Limited Corporation | +86-18900207489 | yiyunchem@163.com | China | 5687 | 58 |
View Lastest Price from 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one pictures](/ProductImageEN/2023-08/Small/989b223f-a648-4a8b-8a6b-435b41e0964b.jpg) |
2024-04-12 | 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
35570-68-4
|
1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | ||
![6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one pictures](https://img.chemicalbook.com/ProductImageEN/2019-7/Small/5c8d5e52-adb9-4cf1-b149-c9096518f1bb.png) |
2019-07-06 | 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
35570-68-4
|
$8.80 | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
35570-68-4
- $0.00
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
-
- 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
35570-68-4
- $8.80
- 97%-99%
- Career Henan Chemical Co
