5-Amino-3-methyl-1-phenylpyrazole
- CAS No.
- 1131-18-6
- Chemical Name:
- 5-Amino-3-methyl-1-phenylpyrazole
- Synonyms
- 3-METHYL-1-PHENYL-1H-PYRAZOL-5-AMINE;3-methyl-1-phenyl-1h-pyrazol-5-amin;-1-phenyL;AKOS B023009;5-Amino-3-methyL;BUTTPARK 30\03-90;TIMTEC-BB SBB003817;ART-CHEM-BB B023009;5-Amino-3-methyl-1-p;5-AMINO-3-METHYL-PHENYLPYRAZOLE
- CBNumber:
- CB8376798
- Molecular Formula:
- C10H11N3
- Molecular Weight:
- 173.21
- MDL Number:
- MFCD00020727
- MOL File:
- 1131-18-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Amino-3-methyl-1-phenylpyrazole 97% | 541001 | 5g | $55.6 |
| 5-Amino-3-methyl-1-phenylpyrazole 97% | 541001 | 25g | $145 |
| 5-Amino-3-methyl-1-phenylpyrazole >98.0%(HPLC)(T) | A1311 | 25g | $48 |
| 5-Amino-3-methyl-1-phenylpyrazole Asreported | 261098 | 50g | $389 |
| 5-Amino-3-methyl-1-phenylpyrazole Asreported | 261098 | 100g | $593 |
| More product size | |||
| Melting point | 114-117 °C (lit.) |
|---|---|
| Boiling point | 333 °C |
| Density | 1.2894 (rough estimate) |
| vapor pressure | 0.006Pa at 25℃ |
| refractive index | 1.6250 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 3.88±0.10(Predicted) |
| form | Solid |
| color | Yellow to pale brown |
| Water Solubility | 6.051g/L at 25℃ |
| InChI | InChI=1S/C10H11N3/c1-8-7-10(11)13(12-8)9-5-3-2-4-6-9/h2-7H,11H2,1H3 |
| InChIKey | FMKMKBLHMONXJM-UHFFFAOYSA-N |
| SMILES | N1(C2=CC=CC=C2)C(N)=CC(C)=N1 |
| LogP | 1.76 |
| CAS DataBase Reference | 1131-18-6(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | X6087GEB2P |
| NIST Chemistry Reference | 1H-Pyrazol-5-amine, 3-methyl-1-phenyl-(1131-18-6) |
| EPA Substance Registry System | 1H-Pyrazol-5-amine, 3-methyl-1-phenyl- (1131-18-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UQ4990000 | |||||||||
| Hazard Note | Harmful | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29331990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Toxicity | mouse,LD50,oral,1300mg/kg (1300mg/kg),BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS",Personal Communication from LONZA Ltd., CH-4002, Basel, SwitzerlandVol. 03FEB1981, | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
5-Amino-3-methyl-1-phenylpyrazole price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 541001 | 5-Amino-3-methyl-1-phenylpyrazole 97% | 1131-18-6 | 5g | $55.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | 541001 | 5-Amino-3-methyl-1-phenylpyrazole 97% | 1131-18-6 | 25g | $145 | 2026-04-30 | Buy |
| TCI Chemical | A1311 | 5-Amino-3-methyl-1-phenylpyrazole >98.0%(HPLC)(T) | 1131-18-6 | 25g | $48 | 2026-04-30 | Buy |
| Usbiological | 261098 | 5-Amino-3-methyl-1-phenylpyrazole Asreported | 1131-18-6 | 50g | $389 | 2026-06-03 | Buy |
| Usbiological | 261098 | 5-Amino-3-methyl-1-phenylpyrazole Asreported | 1131-18-6 | 100g | $593 | 2026-06-03 | Buy |
5-Amino-3-methyl-1-phenylpyrazole Chemical Properties,Uses,Production
Uses
3-methyl-1-phenyl-1H-pyrazol-5-amine is a useful research chemical.
Chemical Properties
Yellow crystalline powder
Uses
5-Amino-3-methyl-1-phenylpyrazole may be used to synthesize:
- substituted pyrazoles
- pyrazolopyridine derivatives
- pyrazolo[3,4,-b]pyridines
General Description
5-Amino-3-methyl-1-phenylpyrazole is an aminopyrazole derivative. It reacts with 6-methyl-4-oxo-4H-[1]-benzopyran-3-carboxaldehyde to yield 5-(2-hydroxy-5-methylbenzoyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine and 2-methoxy-6-methyl-3-(3-methyl-1-phenylpyrazol-5-ylaminomethylene)chroman-4-one.
Flammability and Explosibility
Not classified
Synthesis
1118-61-2
100-63-0
1131-18-6
In a 2-5 mL microwave reaction tube equipped with a stirrer, 3-aminobut-2-enenenitrile (164 mg, 2 mmol) was mixed with 5 mL of 1 M hydrochloric acid solution and stirred until completely dissolved to make a 0.4 M solution of the feedstock. Subsequently, phenylhydrazine (216 mg, 2 mmol) was added to this solution. The reaction tube was sealed with an aluminum cap and placed in a microwave reactor and irradiated at 150 °C for 10 min at a 'very high' absorbance setting. After completion of the reaction, it was cooled to room temperature to obtain a non-homogeneous solution containing an orange precipitate. The pH was adjusted to alkaline with 10% sodium hydroxide solution and sonicated for 5 min to promote solid precipitate formation. The precipitate was collected by filtration, washed twice with deionized water and dried to obtain a light orange solid product (292 mg, 84% yield). For products that do not precipitate easily, the basic aqueous layer can be extracted three times with dichloromethane (DCM) to separate the product. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the target compound.
References
[1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 42, p. 7806 - 7810
[2] Tetrahedron Letters, 2019, vol. 60, # 1, p. 72 - 74
[3] Chemistry of Heterocyclic Compounds, 2018, vol. 54, # 1, p. 51 - 57
[4] Khim. Geterotsikl. Soedin., 2018, vol. 54, # 1, p. 51 - 57,7
[5] Journal of Organic Chemistry, 1993, vol. 58, # 22, p. 6155 - 6157
5-Amino-3-methyl-1-phenylpyrazole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +8617392709771 | 1097@dideu.com | China | 3993 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 923 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Alfa Chemistry | -- | info@alfa-chemistry.com | United States | 2344 | 58 |
View Lastest Price from 5-Amino-3-methyl-1-phenylpyrazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-12-24 | 5-Amino-3-methyl-1-phenylpyrazole
1131-18-6
|
1KG | 98.0% | 10 | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2025-12-24 | 5-Amino-3-methyl-1-phenylpyrazole
1131-18-6
|
1KG | 99.0% | 5000KG | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2020-01-09 | 5-Amino-3-methyl-1-phenylpyrazole
1131-18-6
|
$6.68 | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- 5-Amino-3-methyl-1-phenylpyrazole
1131-18-6
- $0.10
- 98.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-Amino-3-methyl-1-phenylpyrazole
1131-18-6
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-Amino-3-methyl-1-phenylpyrazole
1131-18-6
- $6.68
- 97%-99%
- Career Henan Chemical Co
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