4-Fluoro-2-nitrobenzoic acid
- CAS No.
- 394-01-4
- Chemical Name:
- 4-Fluoro-2-nitrobenzoic acid
- Synonyms
- BUTTPARK 45\01-65;RARECHEM AL BO 1973;Afatinib Impurity 98;2-Nitro-4-Fluoro Benzoic;4-Fluor-2-nitrobenzoesure;2-Nitro-4-Fluoroluere acid;24-Fluoro-2-NitrobenzoicAc;4-Fluoro-2-nitrobenzotc acid;2-NITRO-4-FLUOROBENZOIC ACID;4-FLUORO-2-NITROBENZOIC ACID
- CBNumber:
- CB8774109
- Molecular Formula:
- C7H4FNO4
- Molecular Weight:
- 185.11
- MDL Number:
- MFCD00024300
- MOL File:
- 394-01-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Fluoro-2-nitrobenzoic acid 98% | 115452 | 1g | $117 |
| 4-Fluoro-2-nitrobenzoic Acid >98.0%(GC) | F0737 | 1g | $100 |
| 4-Fluoro-2-nitrobenzoic Acid >98.0%(GC) | F0737 | 5g | $275 |
| 4-FLUORO-2-NITROBENZOICACID 97% | CL4116 | 5G | $19 |
| 4-FLUORO-2-NITROBENZOICACID 97% | CL4116 | 25G | $69 |
| More product size | |||
| Melting point | 140-145 °C (lit.) |
|---|---|
| Boiling point | 343.8±27.0 °C(Predicted) |
| Density | 1.568±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 2.14±0.25(Predicted) |
| color | White to Light yellow |
| InChI | InChI=1S/C7H4FNO4/c8-4-1-2-5(7(10)11)6(3-4)9(12)13/h1-3H,(H,10,11) |
| InChIKey | YLUCXHMYRQUERW-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(F)C=C1[N+]([O-])=O |
| CAS DataBase Reference | 394-01-4(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-37 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
4-Fluoro-2-nitrobenzoic acid price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 115452 | 4-Fluoro-2-nitrobenzoic acid 98% | 394-01-4 | 1g | $117 | 2023-06-20 | Buy |
| TCI Chemical | F0737 | 4-Fluoro-2-nitrobenzoic Acid >98.0%(GC) | 394-01-4 | 1g | $100 | 2026-04-30 | Buy |
| TCI Chemical | F0737 | 4-Fluoro-2-nitrobenzoic Acid >98.0%(GC) | 394-01-4 | 5g | $275 | 2026-04-30 | Buy |
| AstaTech | CL4116 | 4-FLUORO-2-NITROBENZOICACID 97% | 394-01-4 | 5G | $19 | 2026-04-30 | Buy |
| AstaTech | CL4116 | 4-FLUORO-2-NITROBENZOICACID 97% | 394-01-4 | 25G | $69 | 2026-04-30 | Buy |
4-Fluoro-2-nitrobenzoic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
4-Fluoro-2-nitrobenzoic acid has been used to study the reactions of substituted pyridines with the salicyl phosphate dianion.
Biochem/physiol Actions
4-Fluoro-2-nitrobenzoic acid enhances the binding of insulin to adipocytes.
Synthesis
446-10-6
394-01-4
The general procedure for synthesizing 2-nitro-4-fluorobenzoic acid from 2-nitro-4-fluorotoluene is as follows: referring to the method of Examples 2-31, a mixture of 4-fluoro-2-nitrotoluene (25.0 g, 161 mmol), potassium permanganate (102 g, 645 mmol), and water (500 mL) was heated to 100 °C and stirred for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and filtered through diatomaceous earth to remove insoluble manganese dioxide produced by the reduction of potassium permanganate. The filtrate was washed with diethyl ether and adjusted to acidity by adding concentrated hydrochloric acid. Subsequently, the organic material in the acidified aqueous phase was extracted with diethyl ether. The organic phases were combined, washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed by evaporation under reduced pressure to give 2-nitro-4-fluorobenzoic acid (10.1 g, 34% yield). The product was confirmed by NMR hydrogen spectroscopy (CDCl3): δ 7.40 (1H, ddd, J = 2.6 Hz, 7.4 Hz, 8.8 Hz), 7.53 (1H, dd, J = 2.6 Hz, 7.6 Hz), 8.00 (1H, dd, J = 5.6 Hz, 8.8 Hz), 8.52 (1H, br s).
References
[1] Patent: US2003/187014, 2003, A1
[2] Journal of Biological Chemistry, 1954, vol. 207, p. 411,412
[3] Journal of the American Chemical Society, 1963, vol. 85, p. 1792 - 1797
[4] Collection of Czechoslovak Chemical Communications, 1960, vol. 25, p. 784 - 796
[5] Patent: US6635657, 2003, B1
4-Fluoro-2-nitrobenzoic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing CosmicKoda Chemical Technology Co.,Ltd | 8615311061293 15311061293 | JeanWangCosmicKoda@outlook.com | China | 49 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
View Lastest Price from 4-Fluoro-2-nitrobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-02-22 | 4-Fluoro-2-nitrobenzoic acid
394-01-4
|
1KG | 98.8% | 100 tons | Honest Joy Holdings Limited
|
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2019-12-26 | 4-Fluoro-2-nitrobenzoic acid
394-01-4
|
$1.00 | 1KG | 99% | 1000KGS | Career Henan Chemical Co |
-
- 4-Fluoro-2-nitrobenzoic acid
394-01-4
- $0.00
- 98.8%
- Honest Joy Holdings Limited
-
- 4-Fluoro-2-nitrobenzoic acid
394-01-4
- $1.00
- 99%
- Career Henan Chemical Co
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