ChemicalBook >> CAS DataBase List >>(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane

(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane

(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane structure

CAS No.: 110567-22-1

Chemical Name:: (1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane

Synonyms: Entecavir E3;(1S,2R,3S,5R)-3-(Benzyloxy)-2-((benzyloxy)Methyl)-6-oxabicyclo[3.1.0]hexane;Entecavir-3;)-6-oxabicycL;oxy)-2-((benzyL;Entecavir Impurity N3;Entecavir Impurity 48;Entecavir Impurity 110;(1S,2R,3S,5R)-3-(BenzyL;Entecavir Intermediate N7

CBNumber:: CB91450645

Molecular Formula:: C20H22O3

Molecular Weight:: 310.39

MDL Number:: MFCD09750952

MOL File:: 110567-22-1.mol

MSDS File:: SDS

Last updated:2026-05-28 03:57:23

Product description	Number	Pack Size	Price
[1S-(1Alpha,2Alpha,3Beta,5Alpha)]-3-(Phenylmethoxy)-2-[(phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane	TRC-P335720-50MG	50mg	$109
[1S-(1Alpha,2Alpha,3Beta,5Alpha)]-3-(Phenylmethoxy)-2-[(phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane	TRC-P335720-250MG	250mg	$396
[1S-(1Alpha,2Alpha,3Beta,5Alpha)]-3-(Phenylmethoxy)-2-[(phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane	TRC-P335720-100MG	100mg	$179
(1S,2R,3S,5R)-3-(Benzyloxy)-2-((benzyloxy)methyl)-6-oxabicyclo[3.1.0]hexane 95%	AA0083KS	100mg	$28
(1S,2R,3S,5R)-3-(Benzyloxy)-2-((benzyloxy)methyl)-6-oxabicyclo[3.1.0]hexane 95%	AA0083KS	250mg	$34
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(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane Properties

Boiling point	427.9±40.0 °C(Predicted)
Density	1.17
storage temp.	Sealed in dry,2-8°C
solubility	Benzene, Chloroform, DMSO, Methanol
form	Oil
color	Colorless to Pale Yellow
InChI	InChI=1S/C20H22O3/c1-3-7-15(8-4-1)12-21-14-17-18(11-19-20(17)23-19)22-13-16-9-5-2-6-10-16/h1-10,17-20H,11-14H2/t17-,18+,19-,20+/m1/s1
InChIKey	YPDRJNPIGFCETD-WCIQWLHISA-N
SMILES	[C@]12([H])[C@]([H])(O1)C[C@H](OCC1=CC=CC=C1)[C@H]2COCC1=CC=CC=C1
CAS DataBase Reference	110567-22-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Safety Statements	24/25
HS Code	29329990

(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-P335720-50MG	[1S-(1Alpha,2Alpha,3Beta,5Alpha)]-3-(Phenylmethoxy)-2-[(phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane	110567-22-1	50mg	$109	2026-06-03	Buy
TRC	TRC-P335720-250MG	[1S-(1Alpha,2Alpha,3Beta,5Alpha)]-3-(Phenylmethoxy)-2-[(phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane	110567-22-1	250mg	$396	2026-06-03	Buy
TRC	TRC-P335720-100MG	[1S-(1Alpha,2Alpha,3Beta,5Alpha)]-3-(Phenylmethoxy)-2-[(phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane	110567-22-1	100mg	$179	2026-06-03	Buy
aablocks	AA0083KS	(1S,2R,3S,5R)-3-(Benzyloxy)-2-((benzyloxy)methyl)-6-oxabicyclo[3.1.0]hexane 95%	110567-22-1	100mg	$28	2026-05-28	Buy
aablocks	AA0083KS	(1S,2R,3S,5R)-3-(Benzyloxy)-2-((benzyloxy)methyl)-6-oxabicyclo[3.1.0]hexane 95%	110567-22-1	250mg	$34	2026-05-28	Buy

Product number	Packaging	Price	Buy
TRC-P335720-50MG	50mg	$109	Buy
TRC-P335720-250MG	250mg	$396	Buy
TRC-P335720-100MG	100mg	$179	Buy
AA0083KS	100mg	$28	Buy
AA0083KS	250mg	$34	Buy

(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane Chemical Properties,Uses,Production

Chemical Properties

Colorless Oil

Uses

Entecavir intermediate.

Synthesis

100-39-0

(1S,2R,3S,5R)-2-(Benzyloxymethyl)-6-oxabicyclo[3.1.0]hexan-3-ol

117641-39-1

(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane

110567-22-1

General procedure: sodium hydride (55-65%, 0.93 kg, 21.3-25.2 mol) was suspended in anhydrous tetrahydrofuran (25 kg) and stirred for 10 min at room temperature. A solution of (1S,2R,3S,5R)-2-((benzyloxy)methyl)-6-oxabicyclo[3.1.0]hexan-3-ol (2.99 kg, 12.3 mol) in tetrahydrofuran was added slowly and dropwise at 20-30 °C. Subsequently, benzyl bromide (3.14 kg, 18.3 mol) was added dropwise over 2-3 hours at room temperature. After completion of the reaction, the reaction was quenched by the addition of anhydrous ethanol (1.5 kg) and stirred at 10 °C. The solvent was removed by distillation under reduced pressure and the residue was dissolved in ethyl acetate. The resulting solution was washed with saturated saline (10 kg, 3 times) and the organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give (1S,2R,3S,5R)-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane (4.4 kg) as a reddish brown oil.1H NMR (400 MHz, DMSO-d6). δ 1.923-1.960 (1H, m), 2.026-2.087 (1H, m), 2.448-2.436 (1H, m), 3.324-3.520 (3H, m), 3.520 (1H, s), 3.865-3.884 (1H, m), 4.322-4.391 (2H, m), 4.480 (2H, s), 7.251-7.373 (10H, m). HRMS (ESI): m/z calcd for C20H22O3Na [M+Na]+ 333.1467, found 333.1463.

References

[1] Synthesis, 2003, # 13, p. 2101 - 2109
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988, p. 549 - 554
[3] Bioorganic and Medicinal Chemistry Letters, 1997, vol. 7, # 2, p. 127 - 132
[4] Journal of Labelled Compounds and Radiopharmaceuticals, 2009, vol. 52, # 11, p. 485 - 489
[5] Organic Preparations and Procedures International, 2017, vol. 49, # 6, p. 568 - 574

(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane Preparation Products And Raw materials

Raw materials

Benzyl bromide (1S,2R,3S,5R)-2-(Benzyloxymethyl)-6-oxabicyclo[3.1.0]hexan-3-ol Water Tetrahydrofuran Sodium hydride

Preparation Products

2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one 6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine

(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane Suppliers

Global( 151)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21586	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	9544	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30224	58
Handan Tongyi New Material Technology Co., Ltd	+8617330042575	ty003@handantongyi.com	China	351	58

Supplier	Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Alchem Pharmtech,Inc.	58
Shanghai Yingrui Biopharma Co.,Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Zhengzhou Alfa Chemical Co.,Ltd	58
SIMAGCHEM CORP	58
Career Henan Chemica Co	58
Handan Tongyi New Material Technology Co., Ltd	58

View Lastest Price from (1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane 110567-22-1	$1.10	1g	99.0% Min	100 Tons	Dideu Industries Group Limited
2021-12-10	(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane 110567-22-1	$10.00	1KG	99.9%	800kgs/month	Handan Tongyi New Material Technology Co., Ltd
2020-02-26	(1S,2R,3S,5R)-3-(Phenylmethoxy)-2-[(phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane 110567-22-1		10g	99.0%+	100 tons	Shaanxi Dideu Medichem Co. Ltd

(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane
110567-22-1
$1.10
99.0% Min
Dideu Industries Group Limited

(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane
110567-22-1
$10.00
99.9%
Handan Tongyi New Material Technology Co., Ltd

(1S,2R,3S,5R)-3-(Phenylmethoxy)-2-[(phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane
110567-22-1
99.0%+
Shaanxi Dideu Medichem Co. Ltd

110567-22-1((1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane)Related Search:

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1of4

(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane (1S,2R,3S,5R)-3-(Phenylmethoxy)-2-[(phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane [1S-(1a,2a,3,5a)]-3-(Phenylmethoxy)-2-[(phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane 6-Oxabicyclo[3.1.0]hexane, 3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-, (1S, 2R, 3S, 5R) (1S,2R,3S,5R)-3-(Benzyloxymethyl)-6-oxabicyclo[3.1.0]hexane (1S,2R,3S,5R)-3-(Phenylmethoxy)-2-[(phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane ,90% 1R,2R-2-[(Phenylmethoxy)methyl]-3-cyclo penten-1-ol [1S-(1α,2α,3β,5α)]-3-(Phenylmethoxy)-2-[(phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane Entecavir InterMediate III (1R,5S)-3-[(benzyloxy)Methyl]-6-oxabicyclo[3.1.0]hexane Entecavir-3 (1S,2R,3S,5R)-3-(PhenylMethoxy)-2-[(phenylMethoxy)Methyl]-6-oxabicyclo[3.1.]hexane (1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane###110567-22-1 Entecavir Intermediate N7 (1S,2R,3S,5R)-3-(BenzyL )-6-oxabicycL oxy)-2-((benzyL 1S-(1α,2α,3β,5α)]-3-(Phenylmethoxy)-2-[(phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane (1S,2R,3S,5R)-3-(Benzyloxy)-2-[(benzyloxy)methyl]-6-oxabicyclo[3.1.0]hexan (1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane ISO 9001：2015 REACH Entecavir Impurity N3 Entecavir Impurity 110 (1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-o... (1S,2R,3S,5R)-3-(Benzyloxy)-2-((benzyloxy)Methyl)-6-oxabicyclo[3.1.0]hexane Entecavir E3 Entecavir Impurity 48 (1S,2R,3S,5R)-3-(Benzyloxy)-2-((benzyloxy)methyl)-6-oxabicyclo[3.1.0]hexane (Entecavir Impurity) 110567-22-1 Intermediates Intermediates & Fine Chemicals Pharmaceuticals

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