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(S)-3-Hydroxypyrrolidine

(S)-3-Hydroxypyrrolidine structure

CAS No.: 100243-39-8

Chemical Name:: (S)-3-Hydroxypyrrolidine

Synonyms: (S)-PYRROLIDIN-3-OL;(3S)-Pyrrolidin-3-ol;(+)-3-Pyrrolidinol;(S)-3-PYRROLIDINOL;3-(S)-Hydroxypyrrolidine;S-HP;(S)-3-PyrroL;3-PYRROLIDINOL, (S);(3S)-3-Pyrrolidinol;(S)-Pyrrolidine-3-ol

CBNumber:: CB9195781

Molecular Formula:: C4H9NO

Molecular Weight:: 87.12

MDL Number:: MFCD00192426

MOL File:: 100243-39-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:36:13

Product description	Number	Pack Size	Price
(S)-3-Pyrrolidinol ≥97.0% (sum of enantiomers, GC)	56437	5ml	$880
(S)-3-Pyrrolidinol ≥97.0% (sum of enantiomers, GC)	56437	1ml	$220
(S)-3-Pyrrolidinol >97.0%(GC)(T)	P1667	1g	$44
(S)-3-Pyrrolidinol >97.0%(GC)(T)	P1667	5g	$120
(S)-3-Hydroxypyrrolidine	TRC-H953668-500MG	500mg	$97
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(S)-3-Hydroxypyrrolidine Properties

Melting point	15°C
alpha	-6.5 º (c=3.5% in MeOH)
Boiling point	108-110 °C (8 mmHg)
Density	1.078 g/mL at 20 °C (lit.)
refractive index	n20/D 1.490
Flash point	>110°C
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	14.91±0.20(Predicted)
form	Liquid After Melting
Specific Gravity	1.078
color	Clear light yellow to yellow
optical activity	[α]20/D 6.5±1.5°, c = 3.5% in methanol
Water Solubility	Fully miscible in water.
Sensitive	Air Sensitive & Hygroscopic
BRN	4652606
InChI	1S/C4H9NO/c6-4-1-2-5-3-4/h4-6H,1-3H2/t4-/m0/s1
InChIKey	JHHZLHWJQPUNKB-BYPYZUCNSA-N
SMILES	O[C@H]1CCNC1
CAS DataBase Reference	100243-39-8(CAS DataBase Reference)
FDA UNII	PP22TE6CNU
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

HS Code

29339900

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

(S)-3-Hydroxypyrrolidine price More Price(87)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	56437	(S)-3-Pyrrolidinol ≥97.0% (sum of enantiomers, GC)	100243-39-8	5ml	$880	2026-04-30	Buy
Sigma-Aldrich	56437	(S)-3-Pyrrolidinol ≥97.0% (sum of enantiomers, GC)	100243-39-8	1ml	$220	2023-06-20	Buy
TCI Chemical	P1667	(S)-3-Pyrrolidinol >97.0%(GC)(T)	100243-39-8	1g	$44	2026-04-30	Buy
TCI Chemical	P1667	(S)-3-Pyrrolidinol >97.0%(GC)(T)	100243-39-8	5g	$120	2026-04-30	Buy
TRC	TRC-H953668-500MG	(S)-3-Hydroxypyrrolidine	100243-39-8	500mg	$97	2026-06-03	Buy

Product number	Packaging	Price	Buy
56437	5ml	$880	Buy
56437	1ml	$220	Buy
P1667	1g	$44	Buy
P1667	5g	$120	Buy
TRC-H953668-500MG	500mg	$97	Buy

(S)-3-Hydroxypyrrolidine Chemical Properties,Uses,Production

Description

(S)-3-Hydroxypyrrolidine is a chiral organic compound that serves as an important building block in the synthesis of various pharmaceuticals and natural products. It is a four-membered heterocyclic amino alcohol, featuring a hydroxyl group and a stereogenic center. The 'S' prefix indicates the configuration at the stereocenter, which is crucial for its reactivity and biological activity. This compound is notable for its role as an intermediate in the synthesis of drugs, particularly those targeting the central nervous system. The enantiomeric purity of (S)-3-Hydroxypyrrolidine is often critical, as the 'R' and 'S' enantiomers can exhibit different pharmacological properties.

Chemical Properties

clear light yellow to yellow liquid after melting

Uses

(S)-(-)-3-Hydroxypyrrolidine is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.

Purification Methods

The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]

References

[1] Bioscience, Biotechnology and Biochemistry, 1995, vol. 59, # 7, p. 1287 - 1290
[2] Patent: US2006/25470, 2006, A1. Location in patent: Page/Page column 18
[3] Journal of Medicinal Chemistry, 1994, vol. 37, # 14, p. 2138 - 2144

(S)-3-Hydroxypyrrolidine synthesis

Synthesis of (S)-3-Hydroxypyrrolidine from (S)-4-tert-butoxypyrrolidine

(S)-3-Hydroxypyrrolidine Preparation Products And Raw materials

Raw materials

L-Hydroxyproline D-Proline, 1-hydroxy- Ethylene glycol (R)-3-BENZYLOXY-PYRROLIDINE (S)-1-Benzyl-3-pyrrolidinol

Methanol Hydrogen

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Preparation Products

Larotrectinib Sulfate (3R)-(4-FLUOROPHENOXY)-PYRROLIDINE HYDROCHLORIDE [(3S)-3-hydroxypyrrolidin-1-yl](oxan-4-yl)Methanone Pyrrolidine, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (3S)-

(S)-3-Hydroxypyrrolidine Suppliers

Global( 323)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
SyncoZymes (Shanghai) Co., Ltd.,	+86-13681683526（Wechat）	lchen@syncozymes.com	China	286	58
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177	faithe@yan-xi.com	China	5853	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29812	58
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +86-15064153060	sales01@jndxj.com	China	288	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322 +86-18019713315	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49979	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5600	58

Supplier	Advantage
SyncoZymes (Shanghai) Co., Ltd.,	58
Hebei Yanxi Chemical Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Anhui Dexinjia Biopharm Co., Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Richest Group Ltd	58

View Lastest Price from (S)-3-Hydroxypyrrolidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-20	(S)-3-Hydroxypyrrolidine 100243-39-8	$50.00	1kg	0.99	10000	Hebei Yanxi Chemical Co., Ltd.
2025-04-04	(S)-3-Hydroxypyrrolidine 100243-39-8		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2024-11-26	(S)-3-Hydroxypyrrolidine 100243-39-8		1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd

(S)-3-Hydroxypyrrolidine
100243-39-8
$50.00
0.99
Hebei Yanxi Chemical Co., Ltd.

(S)-3-Hydroxypyrrolidine
100243-39-8
98%
Henan Aochuang Chemical Co.,Ltd.

(S)-3-Hydroxypyrrolidine
100243-39-8
98%
Nanjing Fred Technology Co., Ltd

(S)-3-Hydroxypyrrolidine Spectrum

(S)-3-Hydroxypyrrolidine(100243-39-8)¹HNMR (S)-3-Hydroxypyrrolidine(100243-39-8)FT-IR

100243-39-8((S)-3-Hydroxypyrrolidine )Related Search:

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(S)-1-Benzyl-3-pyrrolidinol trans-4-Hydroxy-D-proline SAXITOXIN

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(S)-3-Pyrrolidinol >=97.0% (sum of enantiomers, GC) (S)-(-)-3-HYDROXYPYRROLIDINE (S)-3-HYDROXYPYRROLIDINE S-HP (R)-3-HYDROXYPYRROLIDINE 2-BUTENEDIOATE 3-PYRROLIDINOL, (S) (S)-3-PYRROLIDINOL 99% (S)-(-)-3-HYDROXYPYRROLIDINE , EE 99% (3S)-3-Hydroxypyrrolidine (3S)-3-Pyrrolidinol (3S)-Pyrrolidin-1-ium-3-ol (3S)-Pyrrolidine-3-ol (3S)-Pyrrolidine-3β-ol (S)-Pyrrolidine-3-ol (S)-Pyrrolidine-3β-ol (S)-(-)-3-Pyrrolidinol,99% (S)-(-)-3-Hydroxypyrrolidine, 99%, ee 99% (S)-3-Hydroxypyrrolidine[purum, >=97.0% (sum of enantiomers, GC)] (S)-(-)-3-Pyrrolidinol, 99% 1GR 3-Pyrrolidinol, (3S)- (S)-3-hydroxypyrrolidine[puruM, >=97.0% ] (S)-(-)-3-Pyrrolidiol (S)-3-PYRROLIDINOL (S)-3-HYDROXYPYRROLIDINE (S)-(-)-3-PYRROLIDINOL (S)-3-Hydroxypyrrolidine ((S)-3-Pyrrolidinol) (S)-3-HYDROXYPYROLIDINE HYDROCHLORIDE (S)-(-)-3-Hydroxypyrrolidine, 99%, ee 99+% (S)-3-Pyrrolidinol,99%e.e. (S)-3-hydroxy-pyrrolidinol (S)-3-Pyrrolidinol> (S)-3-PyrroL (s)-3-pyrrolidine alcohol (hydrochloride) (S)-3-Pyrrolidinol (+)-3-Pyrrolidinol (3S)-Pyrrolidin-3-ol (S)-3-PYRROLIDINOL (S)-PYRROLIDIN-3-OL 3-(S)-Hydroxypyrrolidine 100243-39-8 100243-32-0 100234-39-8 Pyrrolidines Heterocyclic Building Blocks Asymmetric Synthesis Chiral Building Blocks Pyrrolidines ,Pyrroles Chiral Building Blocks Simple Alcohols (Chiral) Synthetic Organic Chemistry pharmacetical Alcohols, Hydroxy Esters and Derivatives Chiral Compounds

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