2-(5-Methylpyridin-2-yl)acetonitrile
- CAS No.
- 38203-08-6
- Chemical Name:
- 2-(5-Methylpyridin-2-yl)acetonitrile
- Synonyms
- 5-methyl-2-pyridineacetonitrile;2-Pyridineacetonitrile, 5-methyl-;2-(5-Methylpyridin-2-yl)acetonitrile;1-[2-[4-[(3R,4R)-7-methoxy-3-phenyl-3,4-dihydro-2H-1-benzopyran-4-yl]phenoxy]ethyl]pyrrolidine
- CBNumber:
- CB92552274
- Molecular Formula:
- C8H8N2
- Molecular Weight:
- 132.16
- MDL Number:
- MFCD09923761
- MOL File:
- 38203-08-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-(5-Methylpyridin-2-yl)acetonitrile | NBA20308 | 1g | $342.2 |
| 2-(5-Methylpyridin-2-yl)acetonitrile | NBA20308 | 10g | $1770 |
| 2-(5-Methylpyridin-2-yl)acetonitrile 95% | AS115338 | 1g | $156 |
| 2-(5-Methylpyridin-2-yl)acetonitrile 95% | AS115338 | 5g | $537 |
| 2-(5-Methylpyridin-2-yl)acetonitrile | 313224 | 250.00mg | $56 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H332 |
| Precautionary statements | P280 |
2-(5-Methylpyridin-2-yl)acetonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | NBA20308 | 2-(5-Methylpyridin-2-yl)acetonitrile | 38203-08-6 | 1g | $342.2 | 2026-06-04 | Buy |
| Biosynth | NBA20308 | 2-(5-Methylpyridin-2-yl)acetonitrile | 38203-08-6 | 10g | $1770 | 2026-06-04 | Buy |
| Activate Scientific | AS115338 | 2-(5-Methylpyridin-2-yl)acetonitrile 95% | 38203-08-6 | 1g | $156 | 2026-06-04 | Buy |
| Activate Scientific | AS115338 | 2-(5-Methylpyridin-2-yl)acetonitrile 95% | 38203-08-6 | 5g | $537 | 2026-06-04 | Buy |
| Matrix Scientific | 313224 | 2-(5-Methylpyridin-2-yl)acetonitrile | 38203-08-6 | 250.00mg | $56 | 2026-05-19 | Buy |
2-(5-Methylpyridin-2-yl)acetonitrile Chemical Properties,Uses,Production
Synthesis
3510-66-5
38203-08-6
Step 3 - Preparation of 2-(5-methylpyridin-2-yl)acetonitrile: To a solution of anhydrous acetonitrile (10.1 mL, 191.83 mmol, 3.3 eq.) in anhydrous tetrahydrofuran (500 mL) was added slowly and dropwise at -78 °C a solution of n-butyllithium (2.5 M, 69.8 mL, 174.39 mmol, 3 eq.) in hexanes, protected by nitrogen. The resulting white suspension was stirred at -78 °C for 1 h. Anhydrous tetrahydrofuran (30 mL) solution of 2-bromo-5-methylpyridine (10.0 g, 58.13 mmol, 1 eq.) was added. The reaction mixture was kept at -78 °C for 1 h, followed by a slow warming to room temperature and continued stirring for 1 h. The reaction was completed by the addition of ice water. Upon completion of the reaction, the reaction was quenched by the addition of ice water and layered. The organic layer was washed sequentially with water and brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 18 g of crude product. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=15:1) to afford 2-(5-methylpyridin-2-yl)acetonitrile (6.2 g, 80% yield).1H NMR (300 MHz, CDCl3): δ 8.40 (d, J=3.0 Hz, 1H), 7.54 (dd, J1=3.0 Hz, J2=6.0 Hz. 1H), 7.32 (d, J=6.0 Hz, 1H), 3.90 (s, 2H), 2.40 (s, 3H).
References
[1] Patent: US2009/280230, 2009, A1
2-(5-Methylpyridin-2-yl)acetonitrile Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
2-(5-Methylpyridin-2-yl)acetonitrile Suppliers
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