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6-O-Benzylguanine

6-O-Benzylguanine structure

CAS No.: 19916-73-5

Chemical Name:: 6-O-Benzylguanine

Synonyms: O6-BENZYLGUANINE;6-benzylguanine;O6-Benzylguanine ,98%;6-(benzyloxy)-7H-purin-2-aMine;O6-BenzyL;NSC 637037;6-O-BENZYLGUANINE;6-BENZYLOXY GUANINE;6-oxo -benzylguanine;4 6-Benzyloxyguanine

CBNumber:: CB9263934

Molecular Formula:: C12H11N5O

Molecular Weight:: 241.25

MDL Number:: MFCD00269931

MOL File:: 19916-73-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-03 11:24:09

Product description	Number	Pack Size	Price
O6-Benzylguanine ≥98% (TLC), solid	B2292	50mg	$118
O6-Benzylguanine	B4208	5G	$40
O6-Benzylguanine	B4208	25G	$120
O6-Benzylguanine ≥98%	16332	10mg	$36
O6-Benzylguanine ≥98%	16332	50mg	$62
More product size

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6-O-Benzylguanine Properties

Melting point	193(dec.)
Boiling point	459.3±55.0 °C(Predicted)
Density	1.48±0.1 g/cm3(Predicted)
storage temp.	room temp
solubility	methanol: 20 mg/mL
form	solid
pka	7.47±0.20(Predicted)
color	Off-White to Light Yellow
InChI	InChI=1S/C12H11N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H3,13,14,15,16,17)
InChIKey	KRWMERLEINMZFT-UHFFFAOYSA-N
SMILES	N1C2C(=NC(N)=NC=2OCC2=CC=CC=C2)NC=1
CAS DataBase Reference	19916-73-5(CAS DataBase Reference)
NCI Dictionary of Cancer Terms	O(6)-benzylguanine
FDA UNII	01KC87F8FE
NCI Drug Dictionary	O6-benzylguanine
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

Hazard Note

Irritant

HS Code

29339900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

REACH Registrations

Inactive

NFPA 704

	1
2		0

6-O-Benzylguanine price More Price(108)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B2292	O6-Benzylguanine ≥98% (TLC), solid	19916-73-5	50mg	$118	2026-04-30	Buy
TCI Chemical	B4208	O6-Benzylguanine	19916-73-5	5G	$40	2026-04-30	Buy
TCI Chemical	B4208	O6-Benzylguanine	19916-73-5	25G	$120	2026-04-30	Buy
Cayman Chemical	16332	O6-Benzylguanine ≥98%	19916-73-5	10mg	$36	2026-04-30	Buy
Cayman Chemical	16332	O6-Benzylguanine ≥98%	19916-73-5	50mg	$62	2026-04-30	Buy

Product number	Packaging	Price	Buy
B2292	50mg	$118	Buy
B4208	5G	$40	Buy
B4208	25G	$120	Buy
16332	10mg	$36	Buy
16332	50mg	$62	Buy

6-O-Benzylguanine Chemical Properties,Uses,Production

Chemical Properties

Light Yellow Solid

Uses

O6-Benzylguanine is an effective substrate and efficient inactivator of DNA alkyltransferase. O6-Benzylguanine is an inhibitor of MGMT. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Uses

An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents.

Biochem/physiol Actions

O6-Benzylguanine (O6BG) inhibits methylguanine methyltransferase (MGMT) by blocking the active site through benzyl group transfer. The use of O6BG with bis-chloroethylnitrosourea (BCNU) or carmustine is effective in treating solid tumors including lymphomas, melanomas and sarcoma.

Synthesis

10310-21-1

100-51-6

19916-73-5

GENERAL STEPS: Benzyl alcohol (37.5 g, 0.347 mol) was mixed with sodium hydroxide (2.96 g, 0.074 mol) and heated until the sodium hydroxide was completely dissolved. After the reaction mixture was cooled, 2-amino-6-chloropurine (6.00 g, 0.035 mol) was added and the reaction was stirred at 80-90 °C for 5 hours. After completion of the reaction, methyl tert-butyl ether (120 mL) was added to the reaction mixture and extracted twice with sodium hydroxide solution (70 mL). The alkaline aqueous layers were combined, washed with toluene and subsequently evaporated to remove the toluene. The solution was neutralized to pH 6-8 with 35% hydrochloric acid and the precipitated crystals were collected by filtration. The resulting crude product 2-amino-6-(benzyloxy)purine (7.60 g, 0.032 mol, 92% yield) was dried under reduced pressure.

References

[1] Patent: WO2003/84957, 2003, A1. Location in patent: Page/Page column 9-10
[2] Nucleosides and Nucleotides, 1999, vol. 18, # 10, p. 2219 - 2231
[3] Helvetica Chimica Acta, 2012, vol. 95, # 12, p. 2621 - 2634
[4] Tetrahedron, 2007, vol. 63, # 24, p. 5323 - 5327
[5] Synthetic Communications, 2003, vol. 33, # 6, p. 941 - 952

6-O-Benzylguanine Preparation Products And Raw materials

Raw materials

Acetonitrile N,N-Dimethylformamide Guanine Benzyl alcohol Tetraethylammonium Chloride

6-Chloroguanine Toluene Phosphorus oxitrichloride Ethyl acetate 1,2-Dichloroethane

Hydrochloric acid Acetic acid Sodium hydroxide Activated carbon

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Preparation Products

6-O-Benzylguanine Suppliers

Global( 432)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
airuikechemical co., ltd.	+86-18353166132	sales02@airuikechemical.com	China	983	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6366	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
airuikechemical co., ltd.	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Xiamen AmoyChem Co., Ltd	58

View Lastest Price from 6-O-Benzylguanine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-12	6-O-Benzylguanine 19916-73-5		1KG	99%min	1000kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2026-06-02	O6-Benzylguanine 19916-73-5	$42.00-97.00		98.90%	10g	TargetMol Chemicals Inc.
2025-09-25	O6-Benzylguanine 19916-73-5	$1.00-122.00	1KG	99%		Henan Fengda Chemical Co., Ltd

6-O-Benzylguanine
19916-73-5
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

O6-Benzylguanine
19916-73-5
$42.00-97.00
98.90%
TargetMol Chemicals Inc.

O6-Benzylguanine
19916-73-5
$1.00-122.00
99%
Henan Fengda Chemical Co., Ltd

6-O-Benzylguanine Spectrum

6-O-Benzylguanine(19916-73-5)¹HNMR 6-O-Benzylguanine(19916-73-5)¹HNMR

19916-73-5(6-O-Benzylguanine)Related Search:

EC 2.6.1.2 6-Aminocaproic acid 2-Aminopurine Benzyltrimethylammonium chloride Benzyl chloride

3-Aminophenol 6-Benzylaminopurine Purine Guanine Acetaminophen

Benzyltriethylammonium chloride 4-Methoxybenzylchloride Iminodibenzyl 6-Thioguanine Tris(hydroxymethyl)aminomethane

6-O-Methyl-guanine Glycine Aminoethoxyvinyl glycine hydrochloride

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O(sup 6)benzylguanidine 2-Amino-6-(benzyloxy)-9H-purine 6-(Benzyloxy)-1H-purin-2-amine 6-(PhenylMethoxy)-9H-purin-2-aMine NSC 637037 6-oxo -benzylguanine 6-O-Benzylguanine(O6BG) 9H-Purin-2-amine,6-(phenylmethoxy)- 6-phenylmethoxy-7H-purin-2-amine 2-Amino-6-(benzyloxy)purine 2-amino-6-(phenylmethoxy)-9h-purine 6-O-BENZYLGUANINE 6-BENZYLOXY-9H-PURIN-2-AMINE 6-BENZYLOXY GUANINE 4 6-Benzyloxyguanine 6-BENZYLOXY GUANINE2-AMINO-6-BENZYLOXYPURINE Ganciclovir Impurity 12 O6-BenzyL 2-((2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)propane-1,3-diyl dibenzoate "2-Amino-6-(benzyloxy)purine, 2-Amino-6-(phenylmethoxy)-9H-purine" O6-Benzylguanine ,98% 6-(benzyloxy)-7H-purin-2-aMine 6-benzylguanine 6-(Phenylmethoxy)-1H-purin-2-amine O⁶-Benzylguanine O6-Benzylguanine - Bio-X ? 6-(Benzyloxy)-9H-purin-2-ylamine O6-BENZYLGUANINE 19916-73-5 9916-73-5 Apoptosis and Cell Cycle DNA Repair Regulators DNA metabolism BioChemical Cell Signaling and Neuroscience Cell Biology Alkylguanine-DNA alkyltransferase, mammalian DNA repair proteinApoptosis and Cell Cycle DNA Repair Regulators A to DNA metabolism Enzyme Inhibitors by Enzyme Nucleotides and Nucleosides Bases & Related Reagents Nucleotides

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6-O-Benzylguanine

6-O-Benzylguanine Properties

SAFETY

Risk and Safety Statements

6-O-Benzylguanine price More Price(108)

6-O-Benzylguanine Chemical Properties,Uses,Production

Chemical Properties

Uses

Uses

Biochem/physiol Actions

Synthesis

References

6-O-Benzylguanine Preparation Products And Raw materials

Raw materials

Preparation Products

6-O-Benzylguanine Suppliers

View Lastest Price from 6-O-Benzylguanine manufacturers

6-O-Benzylguanine Spectrum

19916-73-5(6-O-Benzylguanine)Related Search: