Prednisolone-21-acetate
- CAS No.
- 52-21-1
- Chemical Name:
- Prednisolone-21-acetate
- Synonyms
- PREDNISOLONE ACETATE;PREDNISOLONE 21-ACETATE;Sterane;Econopred;Ak-Tate;Prenema;Deltilen;Durapred;Nisolone;Omnipred
- CBNumber:
- CB9274994
- Molecular Formula:
- C23H30O6
- Molecular Weight:
- 402.49
- MDL Number:
- MFCD00037710
- MOL File:
- 52-21-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Prednisolone acetate for peak identification European Pharmacopoeia (EP) Reference Standard | Y0000582 | 15 mg | $254 |
| Prednisolone 21-acetate ≥97% | P8650 | 1g | $71.8 |
| Prednisolone acetate European Pharmacopoeia (EP) Reference Standard | P2800000 | 50 mg | $254 |
| Prednisolone acetate British Pharmacopoeia (BP) Reference Standard | BP1140 | 100MG | $265 |
| Prednisolone acetate United States Pharmacopeia (USP) Reference Standard | 1556008 | 200mg | $440 |
| More product size | |||
| Melting point | 240-244 °C |
|---|---|
| alpha | D25 +116° (dioxane) |
| Boiling point | 579.8±50.0 °C(Predicted) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| refractive index | 112 ° (C=1, Dioxane) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. |
| form | Solid |
| pka | 12.41±0.70(Predicted) |
| color | White to Off-White |
| Water Solubility | 11.6mg/L(25 ºC) |
| Merck | 7721 |
| BRN | 3111798 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Major Application | pharmaceutical (small molecule) |
| InChIKey | LRJOMUJRLNCICJ-JZYPGELDSA-N |
| SMILES | [H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O |
| CAS DataBase Reference | 52-21-1(CAS DataBase Reference) |
| FDA UNII | 8B2807733D |
| NIST Chemistry Reference | 1,4-Pregnadiene-3,20-dione, 11beta,17alpha,21-trihydroxy-, acetate(52-21-1) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360FD |
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
| Hazard Codes | N |
| Risk Statements | 25-34-11 |
| Safety Statements | 45-36/37/39-26-16 |
| WGK Germany | 3 |
| RTECS | TU4152500 |
| HS Code | 29372900 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Repr. 1B |
Prednisolone-21-acetate price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000582 | Prednisolone acetate for peak identification European Pharmacopoeia (EP) Reference Standard | 52-21-1 | 15 mg | $254 | 2026-04-30 | Buy |
| Sigma-Aldrich | P8650 | Prednisolone 21-acetate ≥97% | 52-21-1 | 1g | $71.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | P2800000 | Prednisolone acetate European Pharmacopoeia (EP) Reference Standard | 52-21-1 | 50 mg | $254 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP1140 | Prednisolone acetate British Pharmacopoeia (BP) Reference Standard | 52-21-1 | 100MG | $265 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1556008 | Prednisolone acetate United States Pharmacopeia (USP) Reference Standard | 52-21-1 | 200mg | $440 | 2026-04-30 | Buy |
Prednisolone-21-acetate Chemical Properties,Uses,Production
Chemical Properties
White or almost white, crystalline powder.
Originator
Sterane, Phipharmex ,US ,1955
Uses
glucocorticoid
Uses
Synthetic corticosteroid; metabolically interconvertible with prednisone.
Definition
ChEBI: Prednisolone acetate is a corticosteroid hormone.
Manufacturing Process
To a solution of 0.85 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione (prednisolone) in 5 ml of pyridine are added 3 ml of acetic anhydride. The reaction mixture is allowed to stand at room temperature overnight and is then diluted with ice water. The resulting precipitate is filtered from the mixture and recrystallized from acetone-hexane. There is recovered 0.45 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-acetate, MP 235°239°C. On recrystallization, the MP rose to 237°-239°C.
brand name
Econopred (Alcon); Meticortelone (Schering); Omnipred (Alcon); Sterane (Pfizer).
Therapeutic Function
Glucocorticoid
Biological Activity
Prednisolone Acetate (Omnipred) is a synthetic corticosteroid that is a particularly potent immunosuppressant.
Clinical Use
For rheumatoid arthritis, rheumatic fever, lupus erythematosus, scleroderma, dermatomyositis, acute lymphoblastic leukemia, etc.
Purification Methods
Recrystallise prednisolone acetate from EtOH, Me2CO, Me2CO/hexane, and it has UV with max at 243nm in EtOH. [Joly et al. Bull Soc Chim Fr 366 1958; Herzog et al. J Am Chem Soc 77 4781 1955, Beilstein 8 IV 3468.]
References
[1] Patent: CN105503986, 2016, A. Location in patent: Paragraph 0027; 0028
Prednisolone-21-acetate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| APOLLO HEALTHCARE RESOURCES | sales@apollo-healthcare.com.sg | Singapore | 399 | 58 | |
| Dingwang Technology (Wuhan) Co., Ltd. | +undefined-27-2786652399 +undefined13627115097 | market02@senwayer.com | China | 887 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Kangcang new material Technology Co., LTD | +86-19133911216 | Nancy@kangcang.com.cn | China | 341 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | sarah@tnjone.com | China | 1143 | 58 | |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +86-15383190639 | admin@86-ss.com | China | 999 | 58 |
| Moxin Chemicals | +86-17320513646 +86-17320513646 | anna@molcoo.com | China | 10000 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
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View Lastest Price from Prednisolone-21-acetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-31 | Prednisolone-21-acetate
52-21-1
|
$75.00-100.00 | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-07-27 | Prednisolone acetate
52-21-1
|
$44.00 | 99.55% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-27 | Prednisolone acetate
52-21-1
|
$44.00 | 99.55% | 10g | TargetMol Chemicals Inc. |
-
- Prednisolone-21-acetate
52-21-1
- $75.00-100.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Prednisolone acetate
52-21-1
- $44.00
- 99.55%
- TargetMol Chemicals Inc.
-
- Prednisolone acetate
52-21-1
- $44.00
- 99.55%
- TargetMol Chemicals Inc.
