Prednisolone-21-acetate synthesis
- Product Name:Prednisolone-21-acetate
- CAS Number:52-21-1
- Molecular formula:C23H30O6
- Molecular Weight:402.49
50-24-8
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108-24-7
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52-21-1
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Yield:52-21-1 99.8%
Reaction Conditions:
with 4-dimethylaminopyridine in N,N-dimethyl-formamide at 40; for 0.5 h;Inert atmosphere;
Steps:
1-5 Example 4 Preparation of Compound 2
Under N2 protection, prednisolone 3 (20g, 55.49mmol),100ml of N, N-dimethylformamide (DMF) was added to the reaction flask,The solution was stirred at room temperature.4-dimethylaminopyridine (DMAP, 7.45 g, 60.98 mmol) was added in that order,Acetic anhydride (8.50 g, 83.25 mmol). The mixture was heated to 40 ° C and stirred for 30 minutes.Cool to room temperature, pour into 500ml ice water, and stir for 30min under ice bath conditions.Vacuum filtration, washing with water, and drying to obtain crude product 2 (22.29 g, 99.8%);
References:
CN110540569,2019,A Location in patent:Paragraph 0056-0065
4224-31-1
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52-21-1
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96580-08-4
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52-21-1
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125-10-0
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52-21-1
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28449-43-6
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52-21-1
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