3-Fluoro-4-broMoaniline
- CAS No.
- 656-65-5
- Chemical Name:
- 3-Fluoro-4-broMoaniline
- Synonyms
- 4-BROMO-3-FLUOROANILINE;4-Bromo-3-fluoroanil;3-Fluoro-4-broMoanilin;4-Bromo-3-fluoroaniline98%;4-Bromo-3-fluorobenzenamine;4-BROMO-3-FLUOROPHENYLAMINE;4-Bromo-3-fluoroaniline >4-BroMo-3-fluoroaniline, 97+%;Benzenamine, 4-bromo-3-fluoro-;4 - broMine - 3 - fluoro aniline
- CBNumber:
- CB9345779
- Molecular Formula:
- C6H5BrFN
- Molecular Weight:
- 190.01
- MDL Number:
- MFCD00672933
- MOL File:
- 656-65-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Bromo-3-fluoroaniline 97% | 518719 | 5g | $33.3 |
| 4-Bromo-3-fluoroaniline >98.0%(GC) | B2102 | 1g | $24 |
| 4-Bromo-3-fluoroaniline >98.0%(GC) | B2102 | 5g | $65 |
| 4-Bromo-3-fluoroaniline Asreported | 263634 | 50g | $502 |
| 4-Bromo-3-fluoroaniline Asreported | 263634 | 100g | $741 |
| More product size | |||
| Melting point | 72-73°C |
|---|---|
| Boiling point | 65-68 °C (lit.) |
| Density | 0.982 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 105 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Acetonitrile, Methanol |
| form | Crystalline Powder |
| pka | 2.88±0.10(Predicted) |
| color | Yellow to tan |
| Water Solubility | Soluble in acetonitrile, methanol. Insoluble in water. |
| BRN | 3236457 |
| InChI | InChI=1S/C6H5BrFN/c7-5-2-1-4(9)3-6(5)8/h1-3H,9H2 |
| InChIKey | YTMVYYAKOPIJCZ-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=C(Br)C(F)=C1 |
| CAS DataBase Reference | 656-65-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,T,Xn | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214200 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Fluoro-4-broMoaniline price More Price(108)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 518719 | 4-Bromo-3-fluoroaniline 97% | 656-65-5 | 5g | $33.3 | 2026-04-30 | Buy |
| TCI Chemical | B2102 | 4-Bromo-3-fluoroaniline >98.0%(GC) | 656-65-5 | 1g | $24 | 2026-04-30 | Buy |
| TCI Chemical | B2102 | 4-Bromo-3-fluoroaniline >98.0%(GC) | 656-65-5 | 5g | $65 | 2026-04-30 | Buy |
| Usbiological | 263634 | 4-Bromo-3-fluoroaniline Asreported | 656-65-5 | 50g | $502 | 2026-06-03 | Buy |
| Usbiological | 263634 | 4-Bromo-3-fluoroaniline Asreported | 656-65-5 | 100g | $741 | 2026-06-03 | Buy |
3-Fluoro-4-broMoaniline Chemical Properties,Uses,Production
Chemical Properties
Beige to brown needles and crystalline powder
Uses
4-Bromo-3-fluoroaniline is a intermediate used for the synthetic preparation of Tradizolid and various pharmaceuticals such as the synthesis of several lateral difluoro-substituted 4,4"-dialkyl- and 4 ,4"-alkoxyalkylterphenyls.
Uses
4-Bromo-3-fluoroaniline is an intermediate used for the synthetic preparation of Tradizolid and various pharmaceuticals such as the synthesis of several lateral difluoro-substituted 4,4"-dialkyl- and 4,4"-alkoxyalkylterphenyls.
Synthesis
351-30-4
656-65-5
General procedure for the synthesis of 4-bromo-3-fluoroaniline from 3-fluoro-4-bromoacetanilide: N-(4-bromo-3-fluorophenyl)acetamide (12.9 g, 12.9 mmol) was dissolved in ethanol (30 mL), and stirred until completely dissolved. Subsequently, concentrated hydrochloric acid (15 mL) was added to the solution and the reaction was refluxed at 80 °C for 4 hours. Upon completion of the reaction, the reaction mixture was diluted with ice water and extracted with ethyl acetate. The organic layers were combined and washed sequentially with water and brine solution. Finally, the solvent was removed by vacuum distillation to afford 4-bromo-3-fluoroaniline (2.45 g, 100.0% yield) as an off-white solid.
References
[1] Patent: WO2014/202580, 2014, A1. Location in patent: Page/Page column 97; 98
[2] Molecular Crystals and Liquid Crystals (1969-1991), 1991, vol. 204, p. 43 - 64
[3] Journal of the Chemical Society, 1958, p. 2815,2818
3-Fluoro-4-broMoaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 | bj1@bj-chem.com | China | 299 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
View Lastest Price from 3-Fluoro-4-broMoaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-09 | 4-Bromo-3-fluoroaniline
656-65-5
|
$8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 3-Fluoro-4-broMoaniline
656-65-5
|
1kg | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-04-09 | 4-Bromo-3-fluoroaniline
656-65-5
|
1KG Ton | 98%+ | 2 tons/month | ZHUHAI HRD PHARMACEUTICAL CO., LTD. |
-
- 4-Bromo-3-fluoroaniline
656-65-5
- $8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3-Fluoro-4-broMoaniline
656-65-5
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-Bromo-3-fluoroaniline
656-65-5
- $0.00
- 98%+
- ZHUHAI HRD PHARMACEUTICAL CO., LTD.
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