4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID
![4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Structure](CAS/GIF/39793-31-2.gif)
- CAS No.
- 39793-31-2
- Chemical Name:
- 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID
- Synonyms
- DAO-IN-2;79793-31-2;AKOS BB-9991;CHEMBRDG-BB 4012315;D-Amino Acid Oxidase Inhibitor;Thieno[2,3-b]pyrrole-5-carboxylic acid;4-Thieno[3,2-b]pyrrole-5-carboxylic acid;4H-Thieno[3,2-b]pyrrol-5-carboxylic acid;4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID;4H-thieno[2,3-d]pyrrole-5-carboxylic acid
- CBNumber:
- CB9349944
- Molecular Formula:
- C7H5NO2S
- Molecular Weight:
- 167.19
- MDL Number:
- MFCD07368542
- MOL File:
- 39793-31-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid 97% | 760250 | 500mg | $31.6 |
| D-Amino Acid Oxidase Inhibitor | 138000 | 50mg | $110 |
| D-Amino Acid Oxidase Inhibitor ≥98% | 23894 | 50mg | $28 |
| D-Amino Acid Oxidase Inhibitor ≥98% | 23894 | 100mg | $42 |
| D-Amino Acid Oxidase Inhibitor ≥98% | 23894 | 250mg | $97 |
| More product size | |||
| Melting point | 180 °C |
|---|---|
| Boiling point | 437.4±25.0 °C(Predicted) |
| Density | 1.609 |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 2 mg/ml |
| form | Beige solid |
| pka | 4.36±0.30(Predicted) |
| color | Light brown to gray |
| InChI | InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) |
| InChIKey | PMHDSACGRKBACK-UHFFFAOYSA-N |
| SMILES | N1C(C(O)=O)=CC2SC=CC1=2 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 22-26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 760250 | 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid 97% | 39793-31-2 | 500mg | $31.6 | 2023-06-20 | Buy |
| Sigma-Aldrich | 138000 | D-Amino Acid Oxidase Inhibitor | 39793-31-2 | 50mg | $110 | 2023-01-07 | Buy |
| Cayman Chemical | 23894 | D-Amino Acid Oxidase Inhibitor ≥98% | 39793-31-2 | 50mg | $28 | 2026-04-30 | Buy |
| Cayman Chemical | 23894 | D-Amino Acid Oxidase Inhibitor ≥98% | 39793-31-2 | 100mg | $42 | 2026-04-30 | Buy |
| Cayman Chemical | 23894 | D-Amino Acid Oxidase Inhibitor ≥98% | 39793-31-2 | 250mg | $97 | 2026-04-30 | Buy |
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Chemical Properties,Uses,Production
Uses
DAO-IN-2 is a novel D-amino acid oxidase (DAO) inhibitor. DAO-IN-2 demonstrates moderate potency for DAO in vitro and ex vivo[1].
Synthesis Reference(s)
Journal of the American Chemical Society, 79, p. 2556, 1957 DOI: 10.1021/ja01567a053
General Description
A cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC50 >5 μM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 μM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.
References
[1] Tim Sparey, et, al. The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. Bioorg Med Chem Lett. 2008,18, 11. DOI:10.1016/j.bmcl.2008.04.020
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | info@pbpharm.com | CHINA | 498 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| Golden Pharma Co., Limited | +undefined18958062155 | sales@zjgoldpharm.com | China | 5899 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
View Lastest Price from 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID pictures](https://img.chemicalbook.com/ProductImageEN/2018-12/Small/d5caddb7-6fef-4d11-a3e1-99dc236ef761.png) |
2019-07-06 | 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID
39793-31-2
|
$1.00 | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID
39793-31-2
- $1.00
- 98%
- Career Henan Chemical Co
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