Diethyl L-malate
- CAS No.
- 691-84-9
- Chemical Name:
- Diethyl L-malate
- Synonyms
- (S)-diethyl 2-hydroxysuccinate;DIETHYL L-(-)-MALATE;DIETHYL L-MALATE;Malicaciddiethylester;(S)-(-)-DIETHYLMALATE;DiethylL-(-)-Malate>Malic Acid Impurity 14;L-MALIC ACID DIETHYL ESTER;691-84-9 Diethyl L-malate;L-Matic acid dimethyl ester
- CBNumber:
- CB9428692
- Molecular Formula:
- C8H14O5
- Molecular Weight:
- 190.19
- MDL Number:
- MFCD00210119
- MOL File:
- 691-84-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Diethyl L-(-)-Malate >97.0%(GC) | M1348 | 5g | $28 |
| Diethyl L-(-)-Malate >97.0%(GC) | M1348 | 25g | $107 |
| Diethyl L-(-)-Malate | TRC-D444510-25G | 25g | $212 |
| L-Malic acid diethyl ester | BICL2453 | 10g | $39 |
| L-Malic acid diethyl ester | BICL2453 | 25g | $82 |
| More product size | |||
| alpha | -10.18° |
|---|---|
| Boiling point | 253℃ |
| Density | 1.13 |
| refractive index | 1.4330 to 1.4370 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 12.35±0.20(Predicted) |
| form | Oil |
| color | Colourless |
| Specific Gravity | 1.1280 (20/4℃) |
| Dielectric constant | 9.5（20℃） |
| CAS DataBase Reference | 691-84-9(CAS DataBase Reference) |
| FDA UNII | 6754Q2AK3B |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227 | |||||||||
| Precautionary statements | P501-P210-P280-P370+P378-P403+P235 | |||||||||
| HS Code | 29181990 | |||||||||
| NFPA 704 |
|
Diethyl L-malate price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M1348 | Diethyl L-(-)-Malate >97.0%(GC) | 691-84-9 | 5g | $28 | 2026-04-30 | Buy |
| TCI Chemical | M1348 | Diethyl L-(-)-Malate >97.0%(GC) | 691-84-9 | 25g | $107 | 2026-04-30 | Buy |
| TRC | TRC-D444510-25G | Diethyl L-(-)-Malate | 691-84-9 | 25g | $212 | 2026-06-03 | Buy |
| Apolloscientific | BICL2453 | L-Malic acid diethyl ester | 691-84-9 | 10g | $39 | 2026-06-04 | Buy |
| Apolloscientific | BICL2453 | L-Malic acid diethyl ester | 691-84-9 | 25g | $82 | 2026-06-04 | Buy |
Diethyl L-malate Chemical Properties,Uses,Production
Uses
Diethyl L-(-)-Malate is a reagent in the stereoselective synthesis of crucigasterin A and antitumor activity of crucigasterin A, B, and D.
Definition
ChEBI: Diethyl L-malate is a 3-hydroxy carboxylic acid.
Synthesis
64-17-5
97-67-6
691-84-9
Step 1 (Synthesis of compound 34-2) (0217) L-malic acid (80 g, 600 mmol) was dissolved in anhydrous ethanol (500 mL) and thionyl chloride (100 mL, 1.5 mol) was added slowly and dropwise at 0 °C. The reaction mixture was stirred at 0 °C for 20 min, then warmed to room temperature and continued to stir overnight. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure and the residue was extracted with ethyl acetate (1000 mL x 3). The organic phases were combined and washed sequentially with water (500 mL×2) and saturated sodium chloride solution (500 mL×2), and the organic layer was dried with anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography (eluent system: petroleum ether/ethyl acetate = 20:1) to afford diethyl (S)-2-hydroxysuccinate (113 g, 99% yield). (0218) 1H NMR (400 MHz, CDCl3) δ: 4.47 (q, J = 4.8 Hz, 1H), 4.26 (dq, J = 2.4, 7.2 Hz, 2H), 4.16 (q, J = 7.2 Hz, 2H), 3.28 (d, J = 4.8 Hz, 1H), 2.72-2.89 (m, 2H), 1.20- 1.34 (m, 6H).
References
[1] Patent: US2017/197986, 2017, A1. Location in patent: Paragraph 0216; 0217; 0218
[2] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 9, p. 969 - 974
[3] Journal of Polymer Science, Part A: Polymer Chemistry, 2015, vol. 53, # 22, p. 2586 - 2597
[4] European Journal of Organic Chemistry, 2012, # 5, p. 995 - 1002
[5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 18, p. 5192 - 5194
Diethyl L-malate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3969 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1319 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15079 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
| Changzhou Fullone Chemical Co., Ltd. | +86-13328197671 +86-13861172460 | sales@borenchem.cn | China | 1055 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24597 | 58 |
View Lastest Price from Diethyl L-malate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-31 | Diethyl L-malate
691-84-9
|
20kg | 99% | 20 tons | Qingdao RENAS Polymer Material Co., Ltd. | ||
 |
2026-02-02 | Diethyl L-malate
691-84-9
|
$120.00-1200.00 | 1g | 98%min | 200tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | L-Matic acid dimethyl ester
691-84-9
|
$30.00 | 25KG | 98% | 100kg | Career Henan Chemical Co |
-
- Diethyl L-malate
691-84-9
- $0.00
- 99%
- Qingdao RENAS Polymer Material Co., Ltd.
-
- Diethyl L-malate
691-84-9
- $120.00-1200.00
- 98%min
- Shaanxi Dideu Medichem Co. Ltd
-
- L-Matic acid dimethyl ester
691-84-9
- $30.00
- 98%
- Career Henan Chemical Co
691-84-9(Diethyl L-malate)Related Search:
1of4
