6-Chloro-2-fluoropurine
- CAS No.
- 1651-29-2
- Chemical Name:
- 6-Chloro-2-fluoropurine
- Synonyms
- 6-CHLORO-2-FLUORO-9H-PURINE;uoropurine;6-CHLORO-2-FLUORO;6-CHLORO-2-FLUORPURINE;2-fluoro-6-chloropurine;6-CHLORO-2-FLUOROPURINE;6-chloro-2-fluoro-7H-purine;6-Chloro-2-fluoropurine >6-chloro-2-fluoropurine 98%;9H-Purine, 6-chloro-2-fluoro-
- CBNumber:
- CB9460810
- Molecular Formula:
- C5H2ClFN4
- Molecular Weight:
- 172.55
- MDL Number:
- MFCD02183557
- MOL File:
- 1651-29-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 6-Chloro-2-fluoropurine >97.0%(HPLC)(T) | C2221 | 1g | $101 |
| 6-Chloro-2-fluoropurine ≥98% | 30481 | 250mg | $41 |
| 6-Chloro-2-fluoropurine ≥98% | 30481 | 1g | $80 |
| 6-Chloro-2-fluoropurine Asreported | 267387 | 1g | $337 |
| 6-Chloro-2-fluoropurine Asreported | 267387 | 2g | $468 |
| More product size | |||
| Melting point | 162-163°C |
|---|---|
| Boiling point | 221.8±50.0 °C(Predicted) |
| Density | 1.98±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml |
| form | powder to crystal |
| pka | 4.88±0.20(Predicted) |
| color | White to Light yellow to Green |
| InChI | InChI=1S/C5H2ClFN4/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H,8,9,10,11) |
| InChIKey | UNRIYCIDCQDGQE-UHFFFAOYSA-N |
| SMILES | N1C2C(=NC(F)=NC=2Cl)NC=1 |
| CAS DataBase Reference | 1651-29-2(CAS DataBase Reference) |
| FDA UNII | 726CLW3V39 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335-H319 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338-P280a-P304+P340-P405-P501a | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-41-37/38-22-37/39-26 | |||||||||
| Safety Statements | 26-36/37/39-39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
6-Chloro-2-fluoropurine price More Price(77)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C2221 | 6-Chloro-2-fluoropurine >97.0%(HPLC)(T) | 1651-29-2 | 1g | $101 | 2026-04-30 | Buy |
| Cayman Chemical | 30481 | 6-Chloro-2-fluoropurine ≥98% | 1651-29-2 | 250mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 30481 | 6-Chloro-2-fluoropurine ≥98% | 1651-29-2 | 1g | $80 | 2026-04-30 | Buy |
| Usbiological | 267387 | 6-Chloro-2-fluoropurine Asreported | 1651-29-2 | 1g | $337 | 2026-06-03 | Buy |
| Usbiological | 267387 | 6-Chloro-2-fluoropurine Asreported | 1651-29-2 | 2g | $468 | 2026-06-03 | Buy |
6-Chloro-2-fluoropurine Chemical Properties,Uses,Production
Description
6-Chloro-2-fluoropurine is a heterocyclic building block. It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs) in vitro. 6-Chloro-2-fluoropurine has also been used in the synthesis of purine nucleosides that are active against HIV-1 and hepatitis B virus (HBV) in vitro.
Chemical Properties
Beige solid
Uses
6-Chloro-2-fluoropurine is used as a reagent in the synthesis of several organic compounds including that of 2''-Fluoro-3''-Hydroxymethyl-5''-deoxythreosyl phosphonic acid nucleoside analogues which may potentially act as antiviral agents. It is also used in the synthesis of 2'',5'',5''-trifluoro-3''-hydroxy-apiosyl nucleoside phosphonic acid analogues which may possess potent anti-HCMV properties.
Synthesis
10310-21-1
1651-29-2
General procedure for the synthesis of 6-chloro-2-fluoro-9H-purine from 2-amino-6-chloropurine: 0.3 M NaNO2 aqueous solution (200 mL, 60 mmol) was slowly added dropwise to a vigorously stirred suspension of 2-amino-6-chloro-9H-purine (6.0 g, 35.4 mmol) at -15 °C. Subsequently, 120 mL of 48% HBF4 aqueous solution (0.92 mol) was added over 75 min. The reaction mixture was stirred at room temperature and kept in a light yellow reaction solution state for 20 min. After cooling again to -15 °C, it was neutralized with 50% NaOH aqueous solution to pH=6.0. The water was removed by vacuum and the orange solid obtained was purified by silica gel column chromatography (eluent ratio 90:10 dichloromethane to methanol, Rf value 0.50). 6-Chloro-2-fluoro-9H-purine was finally obtained as a white solid (3.0 g, 49.1% yield).
References
[1] Journal of Organic Chemistry, 1992, vol. 57, # 14, p. 3887 - 3894
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 5, p. 1746 - 1767
[3] Tetrahedron Letters, 1997, vol. 38, # 7, p. 1161 - 1164
[4] Patent: US2002/68721, 2002, A1
[5] Patent: WO2004/16612, 2004, A2. Location in patent: Page 54
6-Chloro-2-fluoropurine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Research New Materials Co., Ltd. | +86-18903931628 +86-18903931531 | sales036@researchvip.com | China | 304 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20111 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32998 | 60 |
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +86-18688942810 | sophieliu@speranzachem.com | China | 923 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21189 | 58 |
| Wuhan Chemwonders Technology Inc. | 027-85778276 | info@chemwonders.com | CHINA | 174 | 58 |
| Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 | sales@unisyn.cn | CHINA | 332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
View Lastest Price from 6-Chloro-2-fluoropurine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-06 | 6-Chloro-2-fluoropurine
1651-29-2
|
$1.00-122.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-07-15 | 6-Chloro-2-fluoropurine
1651-29-2
|
$133.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2026-06-04 | 6-Chloro-2-fluoropurine
1651-29-2
|
50Kg | 98％ | 100kg | Henan Research New Materials Co., Ltd. |
-
- 6-Chloro-2-fluoropurine
1651-29-2
- $1.00-122.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 6-Chloro-2-fluoropurine
1651-29-2
- $133.00
- TargetMol Chemicals Inc.
-
- 6-Chloro-2-fluoropurine
1651-29-2
- $0.00
- 98％
- Henan Research New Materials Co., Ltd.
