ChemicalBook >> CAS DataBase List >>1-Boc-3-hydroxymethyl-piperazine
1-Boc-3-hydroxymethyl-piperazine
- CAS No.
- 301673-16-5
- Chemical Name:
- 1-Boc-3-hydroxymethyl-piperazine
- Synonyms
- tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;1-Boc-3-hydroxymethyl-piperazine;4-N-BOC-2-HYDROXYMETHYLPIPERAZINE;4-N-Bo;1-BOC-3-hydroxymethypiperazine;N-BOC-3-HYDROXYMETHYLPIPERAZINE;4-Boc-2-hydroxymethyl-piperazine;1-N-BOC-3-HYDROXYMETHYLPIPERAZINE;1-N-Boc-3-hydroxymethylpiperazine 98%;4-N-BOC-2-HYDROXYMETHYLPIPERAZINE -HCl
- CBNumber:
- CB9726620
- Molecular Formula:
- C10H20N2O3
- Molecular Weight:
- 216.28
- MDL Number:
- MFCD04115304
- MOL File:
- 301673-16-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 05:55:21
| Product description | Number | Pack Size | Price |
| 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine >98.0%(GC)(T) | B4716 | 200mg | $147 |
| 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine >98.0%(GC)(T) | B4716 | 1g | $635 |
| 4-N-BOC-2-HYDROXYMETHYLPIPERAZINE 97% | 56820 | 1G | $29 |
| 4-N-BOC-2-HYDROXYMETHYLPIPERAZINE 97% | 56820 | 5G | $59 |
| 4-N-BOC-2-HYDROXYMETHYLPIPERAZINE 97% | 56820 | 10G | $99 |
| More product size | |||
| Melting point | 93.0 to 97.0 °C |
|---|---|
| Boiling point | 322.9±22.0 °C(Predicted) |
| Density | 1.085±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 14.97±0.10(Predicted) |
| color | White to Almost white |
| CAS DataBase Reference | 301673-16-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| HS Code | 2939800000 |
1-Boc-3-hydroxymethyl-piperazine price More Price(91)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4716 | 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine >98.0%(GC)(T) | 301673-16-5 | 200mg | $147 | 2024-03-01 | Buy |
| TCI Chemical | B4716 | 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine >98.0%(GC)(T) | 301673-16-5 | 1g | $635 | 2023-06-20 | Buy |
| AstaTech | 56820 | 4-N-BOC-2-HYDROXYMETHYLPIPERAZINE 97% | 301673-16-5 | 1G | $29 | 2026-04-30 | Buy |
| AstaTech | 56820 | 4-N-BOC-2-HYDROXYMETHYLPIPERAZINE 97% | 301673-16-5 | 5G | $59 | 2026-04-30 | Buy |
| AstaTech | 56820 | 4-N-BOC-2-HYDROXYMETHYLPIPERAZINE 97% | 301673-16-5 | 10G | $99 | 2026-04-30 | Buy |
1-Boc-3-hydroxymethyl-piperazine Chemical Properties,Uses,Production
Uses
1-Boc-3-Hydroxymethylpiperazine is an organic compound commonly used as an organic synthesis intermediate and pharmaceutical intermediate.
Synthesis
143540-05-0
301673-16-5
General procedure for the synthesis of 1-BOC-3-hydroxymethylpiperazine from 1,4-bis(Boc)-2-piperazinemethanol: To a solution of di-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (4.00 g, 12.6 mmol) in ethanol (110 ml) was added sodium hydroxide (1.99 g, 49.8 mmol), and the mixture was heated under reflux conditions for 16 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure. The residue was poured into water and the mixture was extracted with ethyl acetate and the organic phase was dried with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford the target product 1-BOC-3-hydroxymethylpiperazine (2.71 g, 99.6% yield) as a solid. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 1.46 (9H, s), 2.12 (1H, br s), 2.64-3.01 (6H, br s), 3.47-3.53 (1H, m), 3.62-3.67 (1H, m), 3.89 (2H, br s).
References
[1] Patent: US2009/318412, 2009, A1. Location in patent: Page/Page column 34-35
[2] Patent: EP1338595, 2003, A2
1-Boc-3-hydroxymethyl-piperazine Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
Global( 190)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Alfa Chemistry | -- | info@alfa-chemistry.com | United States | 2344 | 58 |
View Lastest Price from 1-Boc-3-hydroxymethyl-piperazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-08-09 | 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
301673-16-5
|
$8.80 | 1KG | 97%-99% | 100kg | Career Henan Chemical Co | |
 |
2019-07-11 | 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
301673-16-5
|
$1.00 | 1KG | 98% | 1kg，5kg，100kg | Career Henan Chemical Co |
-
- 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
301673-16-5
- $8.80
- 97%-99%
- Career Henan Chemical Co
-
- 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
301673-16-5
- $1.00
- 98%
- Career Henan Chemical Co
301673-16-5(1-Boc-3-hydroxymethyl-piperazine)Related Search:
1-Boc-3-hydroxymethylpyrrolidine
tert-butyl 3-(cyanoMethyl)piperidine-1-carboxylate
1-Boc-3-(Aminomethyl)azetidine
(R)-1-BOC-3-(Hydroxymethyl)piperazine
(S)-1-(((9H-FLUOREN-9-YL)METHOXY)CARBONYL)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID
1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID
N-4-BOC-N-1-CBZ-2-PIPERAZINE CARBOXYLIC ACID
3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester
N-4-Boc-2-piperazinecarboxylic acid
1of4
2-(HYDROXYMETHYL)-4-N-TERT-BUTOXYCARBONYL-PIPERAZINE
3-(HYDROXYMETHYL)-1-PIPERAZINE CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
REF DUPL: 4-N-Boc-2-hydroxymethylpiperazine
4-Boc-2-hydroxymethyl-piperazine
1-BOC-3-hydroxymethypiperazine
1-Piperazinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester
3-Hydroxymethyl-piperazine-1-carboxylic acid tert-butyl ester ,97%
4-N-Bo
3-(Hydroxymethyl)piperazine, N1-BOC protected
tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine
4-N-BOC-2-HYDROXYMETHYLPIPERAZINE -HCl
1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine
1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine
3-(Hydroxymethyl)-1-piperazinecarboxylic acid tert-butyl ester
N-BOC-3-HYDROXYMETHYLPIPERAZINE
1-N-BOC-3-HYDROXYMETHYLPIPERAZINE
(RS)-1-Boc-3-(hydroxyMethyl)-piperazine
3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID
tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylat
3-(Hydroxymethyl)piperazine, N1-BOC protected 97%
1-N-Boc-3-hydroxymethylpiperazine 98%
4-N-Boc-2-Hydroxymethylpiperazine Hydrochloride
4-N-BOC-2-HYDROXYMETHYLPIPERAZINE
1-Boc-3-hydroxymethyl-piperazine
1-Piperazinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester (9CI, ACI)
3-(hydroxymethyl)-1-Piperazinecarboxylic acid 1,1-dimethylethyl ester (9CI ACI)
tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate
301673-16-5
pharmacetical
Piperaizine
