Evans blue NEW
| Price | $29 |
| Package | 1mL |
| Supply Ability: | 10g |
| Update Time: | 2026-05-15 |
Product Details
| Product Name: Evans blue | CAS No.: 314-13-6 |
| Purity: 86.41% | Supply Ability: 10g |
| Release date: 2026/05/15 |
Product Introduction
Bioactivity
| Name | Evans blue |
| Description | Evans blue (C.I. 23860) is an effective inhibitor of glutamate uptake by synaptic vesicles and also acts as an antagonist of AMPA/kainate receptors. Evans blue is a water-soluble azo fluorescent dye that binds to serum albumin and is used to detect vascular permeability, blood-brain barrier integrity, and permeability. |
| In vitro | Methods: Human glioblastoma U87MG cells (FAP-positive) were treated with 1??Lu-Evans blue-FAPI-B1, B2, B3, B4 (37 kBq) tracers added to each well. Blocking group additionally received 10 μg/well FAPI-02. Treated for 0.5, 1, 2, 4, 8, 24 h. Radioactivity measured by γ-counter to calculate cellular uptake rate (%). Results: All tracers showed time-dependent uptake peaking at 24 h. Blocking agent reduced uptake rate, confirming binding specificity. [1] Methods: HT22 mouse hippocampal neuronal cells were preincubated with Evans blue (1 mM) for 2 hours, then stimulated with glutamate (100 μM) for 30 minutes. ATP concentration in cell culture supernatant was measured by bioluminescence assay. Results: Glutamate stimulation increased ATP release in HT22 cells, and Evans blue pretreatment completely blocked this effect. [2] |
| In vivo | Methods: U87MG tumor-bearing nude mice (initial tumor size ~100 mm3) received a single tail vein injection of different doses of the radiotracer 1??Lu-Evans blue-FAPI-B1 (7.4, 18.5, 30 MBq/mouse). Tumors were observed for 22 days post-treatment. Results: All treatment groups showed significant inhibition of tumor growth compared to the saline control group. [1] Methods: Male SD rats underwent L5 spinal nerve ligation (SNL) model. Intrathecal Evans blue (50 μg/rat) was administered as a single dose starting 7 days post-surgery, with observations conducted for 7 days. Results: Evans blue increased the mechanical pain threshold in a dose-dependent manner, with 50 μg showing optimal efficacy. Analgesic effects persisted for approximately 5 days.[2] |
| Storage | Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 104.1 mM, Sonication is recommended. PBS : 100 mg/mL (104.08 mM), Solution. DMSO : 104.1 mM, Sonication is recommended. |
| Keywords | vesicular glutamate uptake | Inhibitor | inhibit | Evans blue | Direct Blue-53 | Direct Blue53 |
| Inhibitors Related | Indole-2-carboxylic acid | Urethane | Decanoic Acid | N-Methylsarcosine | L-Glutamic acid | N,N-Dimethylglycine hydrochloride | L-Phenylalanine | L-Glutamine | L-Glutamic acid monosodium salt | Memantine | Memantine hydrochloride | Allyl Methyl Sulfide |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | Neuroprotective Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
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