メコバラミン 化學特性,用途語,生産方法
外観
暗赤色～暗褐色, 結(jié)晶～粉末
溶解性
水にやや溶けにくく、エタノールに溶けにくく、アセトニトリルにほとんど溶けない。
用途
薬理研究用。
用途
メチルコバラミン(英: Methylcobalamin; 日本では一般にメコバラミン mecobalamin とも呼ばれる。)は、コバラミン(ビタミンB12)の一種であり、末梢神経障害、糖尿病性神経障害、悪性貧血の治療?筋萎縮性側(cè)索硬化癥の初期治療に用いられている。
用途
ビタミン B12 化合物です。メ
チル基転移反応、カルボキシル基の分子內(nèi)転
移反応に関與しています。
効能
造血薬, 末梢神経障害治療薬, ビタミンB12補充薬
商品名
メコバラミン (キョーリンリメディオ); メチコバール (エーザイ)
使用上の注意
本品は光によって変化する。
説明
Methylcobalamin is an analog of vitamin B12 with diverse neurological activities. It promotes neurite outgrowth and survival in primary cerebellar granule (CGN) and dorsal root ganglion (DRG) cells and activation of ERK1/2 and Akt when used at concentrations ranging from 0.1 to 100 μM. Methylcobalamin (1 mg/kg per day) improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury. It decreases the number of atypical mitochondria in the sciatic nerve and reduces mechanical allodynia and thermal hyperalgesia induced by vincristine in a rat model of neuropathic pain. Methylcobalamin (30 mg/kg) reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of amyotrophic lateral sclerosis (ALS). It also enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer.
化學的特性
Dark Red Crystalline Powder
物理的性質(zhì)
Vitamin B12 is an octahedral cobalt complex consisting of a porphyrin-like, cobalt centered macroring (called a corrin ring or nucleus). The corrinoids are red, red orange, or yellow crystalline substances that show intense absorption spectra above
300 nm owing to the π–π transitions of the corrin nucleus. They are soluble in water
and are fairly stable to heat but decompose at temperatures above ～210 °C without
melting.
Vitamin B12 reacts with ascorbic acid, resulting in the reduction and subsequent
degradation of the former, which releases its cobalt atom as the free ion. Cobalamins
are more stable in the presence of ascorbic acid but unstable to light
使用
One of the biologically active forms of vitamin B12; differing only by the substitution of a methyl for the cyano group. Coenzyme required in the biosynthesis of methionine. Vitamin (hematopoietic).
定義
A vitamin
B
12 analog used as an intermediate in the synthesis of methane. It is responsible for the methylation of inorganic mercury by anaerobic bacteria in
bottom sediments. Through the action of methylcobalamin in an anaerobic bacteria in bottom sediments of aquatic systems, arsenic(III) is methylated
to methanearsonic acid then to cacodylic acid.
副作用
Common side effects of Mecobalamin include: vomiting, diarrhoea, nausea, headache and loss of appetite. Rarely, hypotension, hypokalaemia and thrombocytosis occur. Serious allergic reactions are rare, contact your doctor if you experience hives, difficulty breathing, swelling of the face, lips, tongue or throat, difficulty breathing.
メコバラミン 上流と下流の製品情報
原材料
準備製品