BIBW2992 価格

メーカー	製品番號(hào)	製品説明	CAS番號(hào)	包裝	価格	更新時(shí)間	購(gòu)入

BIBW2992 化學(xué)特性,用途語(yǔ),生産方法

用途

アファチニブ（Afatinib）は、EGFR 遺伝子変異陽(yáng)性の非小細(xì)胞肺癌(NSCLC)の治療に用いられるチロシンキナーゼ阻害薬（英語(yǔ)版）(TKI)の一つである。EGFRおよびerbB-2(HER2)を非可逆的に阻害する。 他國(guó)でも非小細(xì)胞肺癌の治療に用いられる。

説明

In July 2013, the US FDA approved afatinib (also referred to as BIBW- 2992), for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) and with tumors that have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution. Afatinib functions as an irreversible inhibitor by covalently binding directly to the ATP-binding site in the kinase domains of both EGFR(Cys 773) andHER2 (Cys 805;HER-2 is the preferred dimerization partner of EGFR) resulting in downregulation of EGFR signaling. Afatinib is a potent inhibitor of wild-type and mutant forms (L858R) of EGFR (IC_50s of 0.5 and 0.4 nM, respectively), and HER2 (IC₅₀=14 nM), but about 100-fold more active against the gefitinib resistant L858R– T790M EGFR double mutant, with an IC₅₀ of 10 nM. Consistent with its in vitro activity, afatinib induces tumor regression in xenograft and transgenic lung cancer models, with superior activity over erlotinib. A synthetic route to afatinib that employs the displacement of a phenylsulfonyl group to install the (S)-3-hydoxytetrahydrofuran ring and a modified Horner–Wadsworth–Emmons reaction with {[4-(3-chloro-4- phenylamino)-7-((S)-tetrahydrofuran-3-yloxy)-quinazolin-6-ylcarbamoyl]- methyl}-phosphonate and dimethylaminoacetaldehyde-hydrogen sulfite adduct to install the eneamide moiety, has been reported.

使用

BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively.

BIBW2992 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品

BIBW2992 生産企業(yè)

名前	電話番號(hào)	電子メール	國(guó)籍	製品カタログ	優(yōu)位度
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
shandong perfect biotechnology co.ltd	+86-53169958659 +86-13153181156	sales@sdperfect.com	China	294	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20120	58
Shaanxi Xianhe Biotech Co., Ltd	+86-17709210191; +8617709210191	Jerry@xhobio.com	China	906	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Wuhan JiyunZen Tech Co., Ltd.	+86-18062099985	Amyjiyunzen@yeah.net	China	672	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Shanghai Bojing Chemical Co.,Ltd.	+86-86-02137122233 +8613795318958	bj1@bj-chem.com	China	299	55

439081-18-2(BIBW2992)キーワード:

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• 439081-18-2
• Tovok
• Afatinb
• (S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dim
• Tovok, BIBW 2992
• BIBW 2992;TOVOK
• BIBW2992 Afatinib
• Afatinib (BIBW 2992)
• ToMtovok
• (S,E)-N-(4-(3-chloro-4-fluorophenylaMino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(diMethylaMino)but-2-enaMide
• (E)-N-(7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenylaMino)quinazolin-6-yl)-4-(diMethylaMino)but-2-enaMide
• (S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimeth
• (S,E)-N-(4-(3-chloro-4-fluorophenylaMino)-7-(tetrahydrofuran-2-yloxy)quinazolin-6-yl)-4-(diMethylaMino)but-2-enaMide
• (S)-N-(4-((3-Chloro-4-fluorophenyl)aMino)-7-((tetrahydrofuran- 3-yl)oxy)quinazolin-6-yl)-4-(diMethylaMino)but-2-enaMide
• BIBW 2992 N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
• Afatinib, Free Base
• Tofacitinib and its interMediate
• Afatinib, >=99%
• Afatinib (BIBW 2992)r
• Afatinib (BIBW 2992) powder
• (E/Z)-Afatinib
• Afatinib(cis-trans isomerismtautomers)
• Afatinib(W.S)
• AFATINIB; BIBW2992;BIBW-2292
• BIBW-2292
• CS-95
• TOVOK (BIBW-2992, Afatinib)
• [14C]Afatinib
• [14C] (S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dim
• 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-
• Cancer Treatment Afatinib CAS
• N-[4-[(3-クロロ-4-フルオロフェニル)アミノ]-7-[[(S)-テトラヒドロフラン-3-イル]オキシ]-6-キナゾリニル]-4-(ジメチルアミノ)-2-ブテンアミド
• BIBW2992
• N-{4-[(3-クロロ-4-フルオロフェニル)アミノ]-7-[(3S)-オキソラン-3-イルオキシ]キナゾリン-6-イル}-4-(ジメチルアミノ)ブタ-2-エンアミド
• ジオトリフ