セビメリン 化學(xué)特性,用途語,生産方法
効能
唾液分泌促進(jìn)薬, ムスカリン受容體作動薬
化學(xué)的特性
Off-White Solid
使用
A muscarinic M1 and M3 receptor agonist. Sialagogue
合成
The synthesis of cevimeline commences with the epoxidation of the starting material 3-quinuclidinone (2) to yield the intermediate epoxide of 3-methylenequinuclidine (3). This reacts with thiol carboxylic acid RCOSH to form compound (4), which is subsequently converted to the intermediate 3-hydroxy-3-mercaptomethylquinuclidine (5) in the presence of acid or base. and finally purified via a one-pot process.
セビメリン 上流と下流の製品情報
原材料
準(zhǔn)備製品