一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Bioorganic & Medicinal Chemistry >>article
Bioorganic & Medicinal Chemistry

Bioorganic & Medicinal Chemistry

IF: 3.3
Download PDF

Camptothecin: current perspectives

Published:1 April 2004 DOI: 10.1016/j.bmc.2003.11.036 PMID: 15028252
Craig J. Thomas, Nicolas J. Rahier, Sidney M. Hecht

Abstract

This review provides a detailed discussion of recent advances in the medicinal chemistry of camptothecin, a potent antitumor antibiotic. Two camptothecin analogues are presently approved for use in the clinic as antitumor agents and several others are in clinical trials. Camptothecin possesses a novel mechanism of action involving the inhibition of DNA relaxation by DNA topoisomerase I, and more specifically the stabilization of a covalent binary complex formed between topoisomerase I and DNA. This review summarizes the current status of studies of the mechanism of action of camptothecin, including topoisomerase I inhibition and additional cellular responses. Modern synthetic approaches to camptothecin and several of the semi-synthetic methods are also discussed. Finally, a systematic evaluation of novel and important analogues of camptothecin and their contribution to the current structure–activity profile are considered.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
(+)-Camptothecin 7689-03-4 C20H16N2O4 747 suppliers $9.00-$1900.44
TOPOISOMERASE I 80449-01-0 C20H27N3O 45 suppliers Inquiry
Camptothecin 119403-33-7 C20H14N2O4 16 suppliers Inquiry

Similar articles

IF:3.5

Review camptothecin: current perspectives.

Current medicinal chemistry Qing-Yong Li, Yuan-Gang Zu,etc Published: 1 January 2006
IF:4.9

Expeditious Total Syntheses of Camptothecin and 10-Hydroxycamptothecin

Organic Letters Guan-Sai Liu, Qing-Li Dong,etc Published: 7 November 2008
IF:0

CURRENT STATUS OF DISULFIRAM THERAPY

Medical Journal Armed Forces India PK CHAKRABORTY (Retd) Brig , HARPREET SINGH Maj ,etc Published: 1 October 2001
西乌| 天气| 土默特左旗| 徐汇区| 万州区| 酒泉市| 额敏县| 武隆县| 金华市| 清苑县| 普定县| 灯塔市| 邻水| 家居| 波密县| 抚顺县| 镶黄旗| 内乡县| 宾川县| 穆棱市| 衡水市| 隆回县| 涡阳县| 襄城县| 淮滨县| 长顺县| 宣汉县| 东至县| 阿拉尔市| 六枝特区| 虹口区| 奉节县| 运城市| 吉首市| 泗阳县| 双辽市| 武陟县| 额济纳旗| 阿城市| 丰台区| 田林县|