硫酸サルブタモール 化學(xué)特性,用途語,生産方法
溶解性
水に易溶、メタノールに微溶、クロロホルム,エーテルに不溶。水に溶けやすく、エタノール(95)に溶けにくい。
用途
β2 受容體作用剤です。β2 受 容體選択的に作用します。
用途
β2 受容體作用剤です。β2 受
容體選択的に作用します。
効能
気管支拡張薬, β2アドレナリン受容體作動(dòng)薬
商品名
サルタノール (グラクソ?スミスクライン); ベネトリン (グラクソ?スミスクライン); ベネトリン (グラクソ?スミスクライン); ベネトリン (グラクソ?スミスクライン)
説明
Albuterol sulfate (Brand name: PROVENTIL® HFA) is the sulfate form of albuterol which is also known as salbutamol. It is a kind of short-acting, selective beta2-adrenergic receptor agonist being capable of opening up the medium and large airways in the lungs. It is mainly used for the treatment of bronchospasm (induced by bronchial asthma or exercise) as well as chronic obstructive pulmonary disease (COPD). Albuterol sulfate takes effects through directly biding to the beta (2)-adrenergic receptors in the lung and causing relaxation of bronchial smooth muscles. This relaxation is mediated by its effect of stimulating cAMP production through activating adenylate cyclase, further inhibiting the phosphorylation of myosin and lowering the intracellular calcium level. Albuterol sulfate can also be used to treat acute hyperkalemia of the blood.
化學(xué)的特性
Albuterol sulfate is a white or practically white powder, freely soluble in water and slightly soluble in ethanol.
使用
Albuterol Sulfate belongs to a class of bronchodilator drugs called β2-adrenoceptor agonists. It is a prescription medicine used to treat symptoms of bronchospasm. Albuterol Sulfate may be used alone or with other medications.
定義
ChEBI: Albuterol sulfate is an ethanolamine sulfate salt. It is functionally related to an albuterol.
一般的な説明
Albuterol belongs to the class of medicines known as bronchodilators. It is also called a short-acting beta-agonist (SABA).
生物活性
Non-selective β -adrenergic agonist, more potent at β 2 than β 1 receptors.
Mode of action
Albuterol Sulfate is the sulfate salt of the short-acting sympathomimetic agent albuterol, a 1:1 racemic mixture of (R)-albuterol and (S)-albuterol with bronchodilator activity. Albuterol stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. To a lesser extent albuterol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction.
參考文獻(xiàn)
https://en.wikipedia.org/wiki/Salbutamol
https://www.drugbank.ca/drugs/DB01001
http://www.rxlist.com/albuterol-sulfate-drug/indications-dosage.htm
硫酸サルブタモール 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品