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JX401

JX401 ??? ???
?? ??:
349087-34-9
???:
JX401
???(??):
JX401;JX-401, p38alpha inhibitor;p38 MAP Kinase Inhibitor VI, JX401;1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine;1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine;p38 MAP Kinase Inhibitor VI, JX401 - CAS 349087-34-9 - Calbiochem;Methanone, [2-methoxy-4-(methylthio)phenyl][4-(phenylmethyl)-1-piperidinyl]-
CBNumber:
CB01074327
???:
C21H25NO2S
??? ??:
355.49
MOL ??:
349087-34-9.mol
MSDS ??:
SDS

JX401 ??

?? ??
Store at RT
???
DMSO(?? 25mg/ml) ?? ???(?? 20mg/ml)? ?????.
??? ??
??? ??
??
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?? 3?? ?? -20°C?? DMSO ?? ???? ??
InChI
1S/C21H25NO2S/c1-24-20-15-18(25-2)8-9-19(20)21(23)22-12-10-17(11-13-22)14-16-6-4-3-5-7-16/h3-9,15,17H,10-14H2,1-2H3
InChIKey
OMGLGPKQUFSRNN-UHFFFAOYSA-N
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? N
?? ???? ?? 50/53
????? 60-61
????(UN No.) UN 3077 9/PG 3
WGK ?? WGK 3
???? ??? 11 - Combustible Solids
????(GHS): Environment (GHS09)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H410 ??? ??? ?? ????? ?? ??? ?? ????? ?? - ?? ?? 1 ?? P273, P391, P501
??????:
P273 ???? ???? ???.
P391 ???? ????.
P501 ...? ??? / ??? ?? ???.

JX401 C??? ??, ??, ??

??

JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM). It does not inhibit the p38γ isoform. JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.[Cayman Chemical]

???? ??

Potent, reversible inhibitor of p38 α that displays no activity on the p38 γ isoform (IC 50 values are 32 nM and > 10 μ M respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.

JX401 ?? ?? ? ???

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JX401 ?? ??

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JX401 ?? ??:

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