????
|
|
???? ??
- ???
- 205-207°C
- ??
- 1.55±0.1 g/cm3(Predicted)
- ?? ??
- -20°C Freezer
- ???
- DMSO(?? ???), ???(?? ???)
- ?? ?? (pKa)
- 5.67±0.50(Predicted)
- ??? ??
- ??
- ??? ??
- ??? ??
- ??
- ?????
- InChI
- InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1
- InChIKey
- XYDNMOZJKOGZLS-NSHDSACASA-N
- SMILES
- C12N=NN([C@H](C3=CN4C=CN=C4C=C3)C)C1=NC(C1=CN(C)N=C1)=CN=2
- CAS ??????
- 1313725-88-0
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Savolitinib selectively inhibits the MET receptor, blocking the PI3K/AKT/MAPK-signaling pathway as well as downregulating MYC.??
Savolitinib is a potent and highly selective c-Met inhibitor. Savoltinib demonstrated anti-tumor efficacy in a panel of cMet-dysregulated gastric cancer PDX models. Savolitinib also demonstrated good antitmuor activities.Clinical Use
It is currently being evaluated in phase I clinical trials in combination with EGFR TKIs in NSCLC patients.Synthesis
The synthesis of savolitinib started with 6-amino-3-carboxypyridine (20.1), which was treated with chloroacetaldehyde to generate the imidazopyridine 20.2. The carboxylic acid was converted to the Weinreb amide 20.3 and treated with methylmagnesium bromide to give the methyl ketone 20.4. The ketone was converted to the chiral amine 20.5 using a commercially available aminotransferase with the cofactors pyridoxal phosphate and isopropylamine as a nitrogen source. After process workup, the amine was isolated as the dihydrochloride salt (20.5). The free base was obtained by treatment with alkaline conditions, which was subsequently reacted with commercially available 3,5-dibromopyrazin-2-amine (20.6) to give the secondary amine 20.7. Next, nitrosyl ion formation and cyclization gave the 1,2,3-triazole 20.8. Finally, Suzuki coupling with 20.9 completed the construction of savolitinib (20). The boronic acid ester 20.9 was obtained from 4-bromo-1-methyl-1H-pyrazole by lithium-halogen exchange and workup with triisopropylborate quenching.
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N-methoxy-N-methylimidazo[1,2-a]pyridine-6-carboxamide
imidazo[1,2-a]pyridine-6-carboxylic acid
1-Methyl-4-pyrazole boronic acid pinacol ester
6-Aminonicotinic acid
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???( 150)?? ??
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Selumetinib Sulfate
Verteporfin
1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol
Ibrutinib
SU 6668
3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione
Filgotinib
Masitinib
Lestaurtinib
CAL-101
PLX3397 (Pexidartinib)
CO-1686
Momelotinib
Itacitinib
PLX4032
ARRY-334543
X-376