1-(2-THIAZOLYLAZO)-2-NAPHTHOL
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1-(2-THIAZOLYLAZO)-2-NAPHTHOL ??
- ???
- 138-139 °C
- ?? ?
- 464.8±47.0 °C(Predicted)
- ??
- 1.40
- ?? ??
- 2-8°C
- ???
- ???: 10mg/mL, ??
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 8.71±0.50(Predicted)
- ??
- ??? ?? ???
- BRN
- 223783
- ???
- ??? ?? ?????? 1? ?? ??????. DMSO? ???? -20°C?? ?? 1?? ?? ??? ? ????.
- InChI
- 1S/C13H9N3OS/c17-11-6-5-9-3-1-2-4-10(9)12(11)15-16-13-14-7-8-18-13/h1-8,17H
- InChIKey
- IOMXCGDXEUDZAK-UHFFFAOYSA-N
- SMILES
- [s]1c(ncc1)N=Nc2c3c(ccc2O)cccc3
- CAS ??????
- 1147-56-4(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ?? ???? ?? | 36/37/38 | ||
|---|---|---|---|
| ????? | 22-24/25 | ||
| WGK ?? | 3 | ||
| TSCA | TSCA listed | ||
| HS ?? | 2927.00.5000 | ||
| ???? ??? | 11 - Combustible Solids |
1-(2-THIAZOLYLAZO)-2-NAPHTHOL C??? ??, ??, ??
??
1-(2-Thiazolylazo)-2-naphthol is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice.1-(2-THIAZOLYLAZO)-2-NAPHTHOL ?? ?? ? ???
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1-(2-THIAZOLYLAZO)-2-NAPHTHOL ?? ??
???( 126)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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