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2-????????

2-????????
2-???????? ??? ???
?? ??:
614-80-2
???:
2-????????
???(??):
2-???????;2-????????
???:
2-Acetamidophenol
???(??):
2-HYDROXYACETANILIDE;N-(2-Hydroxyphenyl)acetamide;2-ACETYLAMINOPHENOL;AcetaMinophen Related CoMpound C;NSC 398;NSC 3989;2-Acetamino;AKOS BBB/377;O AcetaMinophen;acetoaminophenol
CBNumber:
CB0342159
???:
C8H9NO2
??? ??:
151.16
MOL ??:
614-80-2.mol
MSDS ??:
SDS

2-???????? ??

???
205-210 °C(lit.)
?? ?
273.17°C (rough estimate)
??
1.2023 (rough estimate)
???
1.5810 (estimate)
?? ??
Keep in dark place,Inert atmosphere,Room temperature
???
DMSO(?? ???), ???(?? ???)
??? ??
??
?? ?? (pKa)
9.35±0.35(Predicted)
??
???? ???, ?????
BRN
607592
???
????. ?? ???, ????????, ?, ? ???, ? ???? ???? ????.
InChI
InChI=1S/C8H9NO2/c1-6(10)9-7-4-2-3-5-8(7)11/h2-5,11H,1H3,(H,9,10)
InChIKey
ADVGKWPZRIDURE-UHFFFAOYSA-N
SMILES
C(NC1=CC=CC=C1O)(=O)C
CAS ??????
614-80-2(CAS DataBase Reference)
NIST
Acetamide, N-(2-hydroxyphenyl)-(614-80-2)
EPA
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi,Xn
?? ???? ?? 36/38-22-36/37/38
????? 26-36-37/39
????(UN No.) 2811
WGK ?? 3
RTECS ?? AE4025000
F ?????? 1-8
TSCA TSCA listed
?? ?? 6.1(b)
???? III
HS ?? 29242995
???? ??? 11 - Combustible Solids
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P280 ????/???/???/?????? ?????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P405 ???? ?????.
NFPA 704
1
2 0

2-???????? C??? ??, ??, ??

??? ??

white or light brown powder.soluble in hot water and ethanol, slightly soluble in cold water.

??

An Acetaminophen (A161220) impurity.
2-Acetamidophenol is used as raw material to manufacture industrial organic chemicals.
Acetaminophen is an analgesic and antipyretic agent and used as a pain reliever to treat headache, muscle aches, and arthritis.

?? ??

Mix 2-Aminophenol , acetic acid and Acetic anhydride (i.e., crystals appear), and then directly heated on the fire until all dissolved, stop heating, cooling, water dilution, precipitation of crystals filtered dry, to 70-80 ℃ of ethanol recrystallization to obtain 2-acetamidophenol.

??

ChEBI: 2-acetamidophenol is a member of the class of phenols that is 2-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group. A positional isomer of paracetamol which possesses anti-inflammatory, anti-arthritic and anti-platelet aggregation properties. It has a role as a platelet aggregation inhibitor, an anti-inflammatory agent, a xenobiotic metabolite, an apoptosis inducer, an antineoplastic agent and an antirheumatic drug. It is a member of phenols and a member of acetamides.

?? ??

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Purification Methods

Recrystallise it from water, EtOH or Est aqueous EtOH. [Beilstein 13 H 370, 13 I 113, 13 II 171, 13 III 778.]

2-???????? ?? ?? ? ???

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?? ??


2-???????? ?? ??

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2-???????? ?? ??:

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