???-L-????-L-?? ??

???-L-????-L-?? C??? ??, ??, ??

??

Copper peptide GHK-Cu is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine. The tripeptide has strong affinity for copper(II) and was first isolated from human plasma. It can be found also in saliva and urine.

??

anti-wrikle

??

ChEBI: Gly-His-Lys is a tripeptide composed of glycine, L-histidine and L-lysine residues joined in sequence. It has a role as a metabolite, a chelator, a vulnerary and a hepatoprotective agent.

Biological Functions

When applied topically, copper peptide works as an antioxidant, promote collagen and elastin production, and soften the appearance of fine lines and wrinkles.

Pharmaceutical Applications

Glycyl-l-histidyl-l-lysine (GHK) is a tripeptide known for its high binding affinity to Cu²⁺ and its complex role in wound healing. The GHK–Cu(II) complex was isolated from human plasma in the 1970s and it was shown to be an activator for wound healing. GHK–Cu(II) has two main functions: as an anti-inflammatory agent to protect the tissue from oxidative damage after the injury, and as an activator for wound healing itself as it activates the tissue remodelling.
The structure of GHK is very similar to that of common drugs used to treat ulcers.
After the initial stages of wound healing are activated, such as blood coagulation and neutrophil invasion, a second stage of wound healing begins, which includes the population of GHK at the wound, which has a high affinity to Cu²⁺. Mast cells, which are located in the skin, secrete GHK, which accumulates Cu²⁺ and forms the copper complex GHK–Cu(II) and therefore increases the metal–tripeptide concentration at the wound. First, GHK–Cu(II) has an anti-inflammatory effect by protecting the tissue from oxidative damage and by suppressing local inflammatory signals (i.e. cytokine interleukin-1 (IL-1)). Second, GHK–Cu(II) is released into the blood stream and encourages the production of wound macrophages that support the wound repair by removing the damaged tissue and secreting a family of several growth factor proteins. GHK–Cu(II) also hinders fibroblast production of TGF-β-1 and therefore suppresses the scar development. The GHK–Cu(II) complex also stimulates the growth of blood vessels, neurons and elastin, and, in general, supports most processes of wound healing.

???

While Copper Peptide Serum is generally safe to use, you should be aware of potential side effects that may occur. Although rare, some individuals may experience skin irritation or redness after applying the serum. This can be due to sensitivity to the ingredients or an allergic reaction. Another potential side effect of Copper Peptide Serum is increased sensitivity to sunlight. The serum can make your skin more prone to sunburn.

???-L-????-L-?? ?? ?? ? ???

???

?? ??

???-L-????-L-?? ?? ??

???	??	???	??	?? ?	??
HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD	+86-0086-13751168070 +86-19925801629	sales@huarongpharma.com	China	185	58
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	info@konochemical.com	China	1169	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	+86-519-85525359 +86-15995072465	sales@xuanmingchem.com	China	912	58
ZhenYiBio Technology Inc	+8615309206328	alexxue@zhenyibio.com	China	298	58
Anko Intermational Trade Limited	+86-18073326374	sales@goodpeptides.com	China	59	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-17782035140	sales@zhswyy.com	China	263	58
Jinan Million Pharmaceutical Co., Ltd	0531-68659554 +8613031714605	info@millionpharm.com	China	184	58
Guangzhou XinPeptide International Co.,Ltd	18032808531	admin@xtpeptide.com	China	191	58
Tianjin Shunzhicheng Technology Co., Ltd.	+852-852-91659004 +86-19331907471	sales03@tjszc.com	China	47	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15003564040	1056@dideu.com	China	3969	58

???-L-????-L-?? ?? ??: