Topotecan
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Topotecan ??
- ???
- −114 °C(lit.)
- ?? ?
- >100 °C(lit.)
- ??
- 1.2 g/mL at 25 °C(lit.)
- ?? ??
- 1.3 (vs air)
- ???
- 613 psi ( 21.1 °C)
- ???
- 12 °C
- ?? ??
- Sealed in dry,Store in freezer, under -20°C
- ???
- H2O: ???
- ??? ??
- ??
- ?? ?? (pKa)
- 8.92±0.40(Predicted)
- ??
- ???
- InChI
- InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1
- InChIKey
- UCFGDBYHRUNTLO-QHCPKHFHSA-N
- SMILES
- N1C2C(=C(CN(C)C)C(O)=CC=2)C=C2CN3C(C=12)=CC1[C@](CC)(O)C(=O)OCC=1C3=O
- CAS ??????
- 123948-87-8(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | T,C,F,Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38-67-35-20-11-34-48-46-36 | ||
| ????? | 26-45-36/37/39-37/39-36-22-24/25-16-7 | ||
| ????(UN No.) | UN 3286 3/PG 2 | ||
| WGK ?? | 2 | ||
| RTECS ?? | MW4025000 | ||
| F ?????? | 3 | ||
| ?? ?? | 8 | ||
| ???? | II | ||
| ???? ??? | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Muta. 1B Repr. 2 |
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| ?? ?? ??? | 123948-87-8(Hazardous Substances Data) |
| ????(GHS): |
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| ?? ?: | Danger | ||||||||||||||
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Topotecan C??? ??, ??, ??
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Topotecan was launched in the US for the second-line treatment of ovarian cancer. It can be prepared in four steps from camptothecin and is a water soluble derivative of the natural product with decreased toxicity. Unlike its chemical relative irinotecan, topotecacan in not a prodrug and does not require bioactivation. It is an inhibitor of topoisomerase I. Specifically, it inhibits the release of topoisomerase I from DNA, where it relaxes supercoiled DNA, giving rise to single-strand breaks. When the replication fork reaches this complex, double-stand breaks can occur. This signals apoptosis and eventually gives rise to cell death. Evidence indicates hycamtin is safe for people with impaired hepatic function.??? ??
Off-white Cryst??
(S)-Topotecan is a DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Topotecan hydrochloride is a chemotherapy agent that is a topoisomerase 1 inhibitor.??
ChEBI: A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.Topotecan ?? ?? ? ???
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Topotecan ?? ??
???( 401)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21586 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29815 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 |
52513593@qq.com | CHINA | 2972 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49979 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 |
sales@chemnorm.com | CHINA | 2935 | 58 |
| Hebei Runbin Biotechnology Co. LTD | 13180553332 |
2179877681@qq.com | CHINA | 990 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 |
marketing@targetmol.com | United States | 32466 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 |
sales@win-winchemical.com | China | 14304 | 58 |
Topotecan ?? ??:
???? C ??????? ????? ???, ????? ????? ??
10-HYDROXYCAMPTOTHECIN
Tobramycin
Vancomycin
Topotecan hydrochloride
Topotecan(freebase)
TOPOTECANACETATE
N-DESMETHYL TOPOTECAN
(S)-9-(4-METHYL-1-PIPERAZINYL)METHYL-10-HYDROXYCAMPTOTHECIN
Topotecan-d6 Carboxylic Acid Sodium Salt
Topotecan Carboxylic Acid Sodium Salt
N-Desmethyl Topotecan-d3
TOPOTECAN-D6
Topotecan