(R)-(-)-alpha-Methoxyphenylacetic acid
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(R)-(-)-alpha-Methoxyphenylacetic acid ??
- ???
- 66-68 °C(lit.)
- ?? ?
- 164-166°C 18mm
- ??
- -160.4 º (C=1, MEOH)
- ??
- 1.1708 (rough estimate)
- ???
- -147 ° (C=0.5, EtOH)
- ???
- 164-166°C/18mm
- ?? ??
- 2-8°C
- ???
- ?????, ???, ???? ???
- ??? ??
- ?? ?? ?? ?? ??? ???
- ?? ?? (pKa)
- 3.10±0.10(Predicted)
- ??
- ???
- ?? ??
- [α]20/D -150±3°, c = 0.5% in ethanol
- BRN
- 3589257
- InChI
- 1S/C9H10O3/c1-12-8(9(10)11)7-5-3-2-4-6-7/h2-6,8H,1H3,(H,10,11)/t8-/m1/s1
- InChIKey
- DIWVBIXQCNRCFE-MRVPVSSYSA-N
- SMILES
- CO[C@@H](C(O)=O)c1ccccc1
- CAS ??????
- 3966-32-3(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 26-36 | ||
| WGK ?? | 3 | ||
| HS ?? | 29189900 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
(R)-(-)-alpha-Methoxyphenylacetic acid C??? ??, ??, ??
??? ??
white fine crystalline powder or needles??
(R)-(-)-α-Methoxyphenylacetic Acid is a useful synthetic intermediate. It is used as a reactant in the synthesis of dopamine receptor agonists. It can also be used to prepare hydroxytriamides as potent γ-secretase inhibitors.?? ??
(R)-()-α-Methoxyphenylacetic acid is a chiral derivatizating agent, which is employed for derivatizing enantiomers into diastereoisomers.Purification Methods
Purify the acids by recrystallising from *C6H6/pet ether (b 80-100o). [Neilson & Peters J Chem Soc 1519 1962, Weizmann et al. J Am Chem Soc 70 1153 1948, Pirie & Smith J Chem Soc 338 1932, NMR: Dale & Mosher J Am Chem Soc 9 5 512 1973, for resolution: Roy & Deslongchamps Can J Chem 63 651 1985, Trost et al. J Am Chem Soc 1 0 8 4974 1986.] The racemic mixture has m 72o, b 121-122o/0.4mm, 165o/18mm (from pet ether) [Braun et al. Chem Ber 6 3 2847 1930]. [Beilstein 10 IV 566.](R)-(-)-alpha-Methoxyphenylacetic acid ?? ?? ? ???
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(R)-(-)-alpha-Methoxyphenylacetic acid ?? ??
???( 173)?? ??
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