(5-CYANOPYRIDIN-3-YL)-METHANOL
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(5-CYANOPYRIDIN-3-YL)-METHANOL ??
- ?? ?
- 315.0±27.0 °C(Predicted)
- ??
- 1.25±0.1 g/cm3(Predicted)
- ?? ??
- under inert gas (nitrogen or Argon) at 2-8°C
- ?? ?? (pKa)
- 13.26±0.10(Predicted)
- ??
- White to off-white Solid
- InChI
- InChI=1S/C7H6N2O/c8-2-6-1-7(5-10)4-9-3-6/h1,3-4,10H,5H2
- InChIKey
- MNMDVGJZONSKMO-UHFFFAOYSA-N
- SMILES
- C1=NC=C(CO)C=C1C#N
- CAS ??????
- 135124-71-9
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ????(UN No.) | UN1759 |
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| ?? ?: | Danger | ||||||||||||||
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(5-CYANOPYRIDIN-3-YL)-METHANOL C??? ??, ??, ??
Synthesis
Add lithium aluminum hydride (1.0M in THF; 1.5mL, 1.5mmol, 0.5equiv) over a period of 3 min to a solution of 5-cyano-nicotinic acid methyl ester (479mg, 2.95mmol, 1 equiv) in anhydr THF (15mL) and cool to -78°C After 1h while still at -78°C, quench the reaction with H2O (60μL), 5M aq NaOH (60μL), and more H2O (180μL). Filter the reaction mixture through paper. Rotary evaporate the filtrate (40°C) to give 369mg of material as a yellow solid. Transfer this material to a column of silica gel (130mm x 25mmdia.) and elute (2% MeOH/CH2Cl2) to yield 180mg of a mixture of ester, hemiacetal, and aldehyde as a yellow solid and 45mg (11%) of 5-hydroxymethyl-nicotinonitrile as a yellow solid. MS (m/e): 163.07 (M+1).(5-CYANOPYRIDIN-3-YL)-METHANOL ?? ?? ? ???
???
?? ????
5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER
5-Bromo-3-pyridinemethanol
??? ?I??
Bis(dibenzylideneacetone)palladium
N,N-?????????
1,1'- ?? (? ?? ?? ??) ???
?? ??
(5-CYANOPYRIDIN-3-YL)-METHANOL ?? ??
???( 96)?? ??
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(5-CYANOPYRIDIN-3-YL)-METHANOL ?? ??:
METHYL 5-CYANO-6-HYDROXY-2-METHYLNICOTINATE
ETHYL 2-CHLORO-3-CYANO-6-(TRIFLUOROMETHYL)-PYRIDINE-5-CARBOXYLATE
ETHYL 5-CYANO-6-MERCAPTO-2-METHYLNICOTINATE
BUTTPARK 82\12-87
METHYL 5-CYANO-2-(DIMETHOXYMETHYL)-6-MERCAPTONICOTINATE
METHYL 5-CYANO-6-[(4-METHOXYPHENYL)SULFANYL]-2-METHYLNICOTINATE
ETHYL 5-CYANO-6-MERCAPTO-2-PHENYLNICOTINATE
METHYL 5-CYANO-2-METHYL-6-[3-(TRIFLUOROMETHYL)PHENOXY]NICOTINATE
ETHYL 5-CYANO-6-([2-(([(2,6-DICHLORO-4-PYRIDYL)AMINO]CARBONYL)AMINO)PHENYL]THIO)-2-(TRIFLUOROMETHYL)NICOTINATE
METHYL 5-CYANO-6-(4-METHOXYPHENOXY)-2-METHYLNICOTINATE
METHYL 5-CYANO-6-METHOXY-2-METHYLNICOTINATE
2,4-DIMETHYL-5-OXO-5H-CHROMENO[3,4-C]PYRIDINE-1-CARBONITRILE
AURORA KA-6192
ETHYL 5-CYANO-6-ETHOXY-2-HYDROXYNICOTINATE
METHYL 5-CYANO-6-(2,4-DICHLOROPHENOXY)-2-METHYLNICOTINATE
ETHYL 5-CYANO-6-(METHYLSULFANYL)-2-PHENYLNICOTINATE
METHYL 5-CYANO-2-METHYL-6-(PHENYLSULFANYL)NICOTINATE
METHYL 5-CYANO-6-(4-FLUOROPHENOXY)-2-METHYLNICOTINATE