??????????????
|
|
?????????????? ??
- ???
- 77.5-78.5 °C(Solv: hexane (110-54-3))
- ?? ?
- 119 °C(lit.)
- ??
- 1.152 g/mL at 25 °C(lit.)
- ???
- n
20/D 1.452(lit.)
- ???
- 74 °F
- ?? ??
- 2-8°C
- ???
- ?????? ???
- ??? ??
- ??
- Specific Gravity
- 1.1520
- ??
- ????~???
- ???
- ??? ????
- ??
- Moisture Sensitive
- BRN
- 471286
- ???
- ??? ???
- InChI
- 1S/C4H5ClO/c5-4(6)3-1-2-3/h3H,1-2H2
- InChIKey
- ZOOSILUVXHVRJE-UHFFFAOYSA-N
- SMILES
- ClC(=O)C1CC1
- CAS ??????
- 4023-34-1(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | C,F | ||
|---|---|---|---|
| ?? ???? ?? | 10-34-29-25-36-38 | ||
| ????? | 26-36/37/39-45-8-16 | ||
| ????(UN No.) | UN 2920 8/PG 2 | ||
| WGK ?? | 3 | ||
| F ?????? | 10-21 | ||
| TSCA | TSCA listed | ||
| ?? ?? | 8 | ||
| ???? | II | ||
| HS ?? | 29162000 | ||
| ???? ??? | 3 - Flammable liquids | ||
| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 Flam. Liq. 3 Skin Corr. 1B |
||
| ?? | LD50 orally in Rabbit: 200 mg/kg | ||
| ???? ?? | KE-09318 |
?????????????? C??? ??, ??, ??
??? ??
clear colorless to slightly yellow liquid??
Cyclopropanecarbonyl chloride can be used as an alkylating reagent in the preparation of some chemical building blocks such as formylcyclopropane, cyclopropanecarboxylic acid hydrazide, bis(cyclopropylcarbonyl) peroxide, 1-cyclopropanecarboxamide, 2-cyclopropylcarbonylcyclohexane-1,3-diones and cyclopropyl analog of triazolopiperazine-amides.???
Cyclopropanecarbonyl chloride is acute oral toxicity, it causes skin corrosion/Irritation and serious eye damage/eye irritation.Purification Methods
If the IR shows OH bands, then some hydrolysis to the free acid must have occurred. In this case heat with oxalyl chloride at 50o for 2hours or SOCl2 for 30minutes, then evaporate and distil three times using a Dufton column (p 10). Store it in an inert dry atmosphere, preferably in sealed tubes. Strong IRRITANT. If it is free from OH bands, then just distil it in vacuo and store as before. [Jeffrey & Vogel J Chem Soc 1804 1948, Beilstein 9 IV 4.]?????????????? ?? ?? ? ???
???
?? ??
??????
???????
Filgotinib
3-CYCLOPROPYL-3-OXO-PROPIONIC ACID ETHYL ESTER
????,1-(??????????)-,??????????
???????2-????????
Cyclopropyl 4-methoxyphenyl ketone
N-METHOXY-N-METHYLCYCLOPROPANECARBOXAMIDE
???????????(5-???-[1,2,4]?????[1,5-a]???-2-?)-???
TAK-632
Cyclopropanecarboxamide, N-(4-chloro-2-methylphenyl)-
3',4'-DICHLOROCYCLOPROPANECARBOXANILIDE
?????????????? ?? ??
???( 460)?? ??
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