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Maytansinol

Maytansinol ??? ???
?? ??:
57103-68-1
???:
Maytansinol
???(??):
Maytansinoid;AP0;(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-Chloro-14,4-dihydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-diene-12,6-dione;Maytansino;Maytasinol;MAYTANSINOL;ansaMitocin p 0;Maytansinol, >=95%;antibiotic c 15003p;Maytansine,3-O-de[2-
CBNumber:
CB41214082
???:
C28H37ClN2O8
??? ??:
565.05
MOL ??:
57103-68-1.mol

Maytansinol ??

???
205-207℃
?? ?
835.8±65.0 °C(Predicted)
??
1.34±0.1 g/cm3(Predicted)
?? ??
2-8°C
???
?????(?? ???), ???(?? ???)
??? ??
??
??? ??
??? ??
?? ?? (pKa)
9.89±0.70(Predicted)
??
????? ?????
InChIKey
QWPXBEHQFHACTK-ZNNAZLLLNA-N
SMILES
C[C@]12[C@H](CC(N(C3=C(C(OC)=CC(CC(C)=CC=C[C@@]([H])(OC)[C@@]4(NC(=O)O[C@@]([H])(C4)[C@@H](C)[C@@H]1O2)O)=C3)Cl)C)=O)O |t:15,17,&1:1,2,19,23,28,31,33,r|
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): Skull and Crossbones (GHS06)Exclamation Mark (GHS07)Health Hazard (GHS08)
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
H340 ???? ??? ??? ? ?? (????? ???? ????? ???? ???? ???? ??? ?? ????? ??? ???? ??) ???? ???? ?? ?? 1A, 1B ??
??????:
P201 ?? ? ?? ???? ?????.
P202 ?? ?? ?? ??? ?? ???? ??? ???? ???.
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P271 ?? ?? ??? ? ?? ???? ?????.
P280 ????/???/???/?????? ?????.
P301+P310 ???? ?? ????(??)? ??? ????.
P302+P352 ??? ??? ??? ?? ????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.
P312 ???? ??? ????(??)? ??? ????.
P321 (…) ??? ???.
P330 ?? ?????.
P332+P313 ?? ??? ??? ???? ??· ??? ????.
P337+P313 ?? ?? ??? ???? ???? ??· ??? ????.
P403+P233 ??? ??? ? ?? ?? ??? ???? ?????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.
NFPA 704
0
4 0

Maytansinol C??? ??, ??, ??

??

Maytansinol (Ansamitocin P-0) is an inhibitor of microtubule assembly that induces microtubule disassembly in vitro.

??

Maytansinol is used in the preparation of site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity. References Pillow, T.H., et. al.: J. Med. Chem., 57, 7890 (2014)

???? ??

Maytansinol is an ansamacrolide originally isolated from P. verrucose that has antimitotic and anticancer activities. It inhibits polymerization and induces depolymerization of bovine brain tubulin with EC50 values of 12 and 43 μM, respectively. Maytansinol inhibits sea urchin egg mitosis when used at a concentration of 10 μM and decreases proliferation of KB nasopharyngeal cancer cells (EC50 = 0.19 μg/ml).

Maytansinol ?? ?? ? ???

???

?? ??


Maytansinol ?? ??

???( 233)?? ??
??? ?? ??? ?? ?? ? ??
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Maytansinol ?? ??:

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